Comparison of hindlimb unloading and partial weight suspension models for spaceflight-type condition induced effects on white blood cells

Animal models are frequently used to assist in the determination of the long- and short-term effects of space flight. The space environment, including microgravity, can impact many physiological and immunological system parameters. It has been found that ground based models of microgravity produce changes in white blood cell counts, which negatively affects immunologic function. As part of the Center of Acute Radiation Research (CARR), we compared the acute effects on white blood cell parameters induced by the more traditionally used animal model of hindlimb unloading (HU) with a recently developed reduced weightbearing analog known as partial weight suspension (PWS). Female ICR mice were either hindlimb unloaded or placed in the PWS system at 16% quadrupedal weightbearing for 4 h, 1, 2, 7 or 10 days, at which point complete blood counts were obtained. Control animals (jacketed and non-jacketed) were exposed to identical conditions without reduced weightbearing. Results indicate that significant changes in total white blood cell (WBC), neutrophil, lymphocyte, monocyte and eosinophil counts were observed within the first 2 days of exposure to each system. These differences in blood cell counts normalized by day 7 in both systems. The results of these studies indicate that there are some statistically significant changes observed in the blood cell counts for animals exposed to both the PWS and HU simulated microgravity systems.     

Naval EarthMap Observer (NEMO) program and the Naval Space Science and Technology Program Office

In February 1997 the Chief of Naval Research chartered the Naval Space Science and Technology (S&T) Program Office, at the Office of Naval Research, to operate as the central point of contact for the Department of the Navy's (DON's) S&T activities in space. The Office was chartered to enhance the DON's space efforts through interdepartmental integration and linkage with external Department of Defense (DOD) commands and government agencies. The Office's goal is to optimize a plan for S&T coherency, synergy, and relevancy to effect technology transition to the DON's Systems Commands or Program Executive Offices (PEO's) while developing an investment strategy that accommodates and leverages the commonality of commercial and consumer thrust areas and products.

This paper will focus on the “Flagship” Naval Space S&T Program, the Naval EarthMap Observer (NEMO) Program, as one example of how the Office is executing its mission. It will discuss how, through NEMO, the Navy is able to leverage commercial industry and other US government agency requirements and resources to meet unique Naval needs. Finally, the paper will discuss the specifics of NEMO, the Navy's roles and responsibilities and how the Navy will use NEMO in its mission to characterize the littoral regions of the world.

Through the NEMO satellite system, the Navy will develop a large hyperspectral imagery database which will be used to characterize and model the littoral regions of the world. NEMO will provide images using its Coastal Ocean Imaging Spectrometer (COIS) Instrument along with a co-registered 5m Panchromatic Imager (PIC). With 210 spectral channels over a bandpass of 0.4 to 2.5μm and very high signal-to-noise ratio (SNR), the COIS instrument is optimized for the low reflectance environment of the littoral region. COIS will image over a 30km wide swath with a 60m Ground Sample Distance (GSD), and can image at a 30m GSD with ground motion compensation. A 10:30am, sun-synchronous circular orbit of 605km enables continuous repeat coverage of the whole earth. A unique aspect of the system is the spectral feature extraction and data compression software algorithm developed by the Naval Research Laboratory (NRL) called the Optical Real-Time Spectral Identification System (ORA-SIS). ORASIS employs a parallel, adaptive hyperspectral method for real-time scene characterization, data reduction, background suppression, and target recognition. The use of ORASIS is essential for management of the massive amounts of data expected from the NEMO HSI system, and for development of Naval products. Specific Naval products include bathymetry, water clarity, bottom type, atmospheric visibility, bioluminescence, beach characterization, under-water hazards, total column atmospheric water vapor, and detection and mapping of sub-visible cirrus. Demonstrations of timely downlinks of real-time hyperspectral imagery data to the Naval warfighter are also being developed. The NEMO satellite is planned for launch in mid-2000 followed by an operational period of 3 to 5 years.     

Future of Venus Research and Exploration

Despite the tremendous progress that has been made since the publication of the Venus II book in 1997, many fundamental questions remain concerning Venus’ history, evolution and current geologic and atmospheric processes. The international science community has taken several approaches to prioritizing these questions, either through formal processes like the Planetary Decadal Survey in the United States and the Cosmic Vision in Europe, or informally through science definition teams utilized by Japan, Russia, and India. These questions are left to future investigators to address through a broad range of research approaches that include Earth-based observations, laboratory and modeling studies that are based on existing data, and new space flight missions. Many of the highest priority questions for Venus can be answered with new measurements acquired by orbiting or in situ missions that use current technologies, and several plausible implementation concepts have been studied and proposed for flight. However, observations needed to address some science questions pose substantial technological challenges, for example, long term survival on the surface of Venus and missions that require surface or controlled aerial mobility. Missions enabled by investments in these technologies will open the door to completely new ways of exploring Venus to provide unique insights into Venus’s past and the processes at work today.     

Solar modulation and nuclear fragmentation effects in galactic cosmic ray transport through shielding.

Crews of manned interplanetary missions may accumulate significant radiation exposures from the galactic cosmic ray (GCR) environment in space. Estimates of how these dose levels are affected by the assumed temporal and spatial variations in the composition of the GCR environment, and by the effects of the spacecraft and body self-shielding on the transported radiation fields are presented. In this work, the physical processes through which shielding alters the transported radiation fields are described. We then present estimates of the effects on model calculations of (1) nuclear fragmentation model uncertainties, (2) solar modulation, (3) variations between solar cycles, and (4) proposed changes to the quality factors which relate dose equivalent to absorbed dose.     

Nonlinear Filter Evaluation for Estimating Vehicle Position and Velocity Using Satellites

Approximate nonlinear filtering theory is applied to the estimation of vehicle position and velocity in three demensions using sequential range measurements to three known locations. The particular case studied is a satellite air traffic control system which utilizes range measurements to two geostationary satellites and an altitude measurement. Three approximate filters are examined as suboptimal realizations of the minimum-variance filter and simulation results are presented to show that simple first-order approximation is an adequate representation. The parametric relationship between state covariance, measurement noise, vehicle maneuver structure, data rate, and system geometry is presented.     

State Trajectories Used to Observe and Control DC-to-DC Converters

State-plane analysis techniques are employed to study the voltage stepup energy-storage dc-to-dc converter. Within this framework, an example converter operating under the influence of a constant on-time and a constant frequency controller is examined. Qualitative insight gained through this approach is used to develop a conceptual free-running control law for the voltage stepup converter which can achieve steady-state operation in one on/off cycle of control. Digital computer simulation data are presented to illustrate and verify the theoretical discussions presented.     

Overview of atmospheric ionizing radiation (AIR) research: SST-present.

The Supersonic Transport (SST) program, proposed in 1961, first raised concern for the exposure of pregnant occupants by solar energetic particles (SEP), and neutrons were suspected to have a main role in particle propagation deep into the atmosphere. An eight-year flight program confirmed the role of SEP as a significant hazard and of the neutrons as contributing over half of the galactic cosmic ray exposures, with the largest contribution from neutrons above 10 MeV. The FAA Advisory Committee on the Radiobiological Aspects of the SST provided operational requirements. The more recent lowering of ICRP-recommended exposure limits (1990) with the classification of aircrew as "radiation workers" renewed interest in GCR background exposures at commercial flight altitudes and stimulated epidemiological studies in Europe, Japan, Canada and the USA. The proposed development of a High Speed Civil Transport (HSCT) required validation of the role of high-energy neutrons, and this resulted in ER-2 flights at solar minimum (June 1997) and studies on effects of aircraft materials on interior exposures. Recent evaluation of health outcomes of DOE nuclear workers resulted in legislation for health compensation in year 2000 and recent European aircrew epidemiological studies of health outcomes bring renewed interest in aircraft radiation exposures. As improved radiation models become available, it is imperative that a corresponding epidemiological program of US aircrew be implemented.     

H0323+022: Classification as a BL Lac and EXOSAT coordinated observations

The object H0323+022 (Doxsey et al. 1983) has been shown to be a BL Lac object by virtue of a diversity of observational characteristics at radio, optical, and x-ray wavelengths, in agreement with the conclusion of Margon and Jacoby (1984). Multi-frequency coordinated observations of this highly variable object with EXOSAT in September 1984 found it to be in a faint quiescent state (1/3; Jy at 5 keV and V=16.55). Preliminary results from the latter observations are presented.     

Microscopic track structure of equal-LET heavy ions.

The spatial distributions of ionization and energy deposition produced by high-velocity heavy ions are crucial to an understanding of their radiation quality as exhibited eg., in track segment experiments of cell survival and chromosome aberrations of mammalian cells. The stopping power (or LET) of a high velocity ion is proportional to the ratio z2/v2, apart from a slowly varying logarithmic factor. The maximum delta-ray energy that an ion can produce is proportional to v2 (non-relativistically). Therefore, two HZE ions having the same LET, but in general differing z and v will have different maximum delta-ray energies and consequently will produce different spatial patterns of energy deposition along their paths. To begin to explore the implications of this fact for the microscopic dosimetry of heavy ions, we have calculated radial distributions in energy imparted and ionization for iron and neon ions of approximately equal LET in order to make a direct comparison of their delta-ray track structure. Monte Carlo techniques are used for the charged particle radiation transport simulation.     

New ways to rotation rates

Progress in determining rotation rates of Algol primary stars from light curves is assessed. Included are elementary ideas on why the new method works, how to carry out solutions, and how and when to apply the constraint on rotational lobe filling. Some comments are made on desirable improvements for measuring rotation from line broadening. A few remarks are made about the problem of identifying likely fast rotating Algols.