French research program on the physiological problems caused by weightlessness. Use of the primate model

The need to acquire a better knowledge of the main biological problems induced by microgravity implies--in addition to human experimentation--the use of animal models, and primates seem to be particularly well adapted to this type of research. The major areas of investigation to be considered are the phospho-calcium metabolism and the metabolism of supporting tissues, the hydroelectrolytic metabolism, the cardiovascular function, awakeness, sleep-awakeness cycles, the physiology of equilibrium and the pathophysiology of space sickness. Considering this program, the Centre d'Etudes et de Recherches de Medecine Aerospatiale, under the sponsorship of the Centre National d'Etudes Spatiales, developed both a program of research on restrained primates for the French-U.S. space cooperation (Spacelab program) and for the French-Soviet space cooperation (Bio-cosmos program), and simulation of the effects of microgravity by head-down bedrest. Its major characteristics are discussed in the study.     

A technique for estimating the probability of radiation-stimulated failures of integrated microcircuits in low-intensity radiation fields: Application to the Spektr-R spacecraft

In developing radio-electronic devices (RED) of spacecraft operating in the fields of ionizing radiation in space, one of the most important problems is the correct estimation of their radiation tolerance. The “weakest link” in the element base of onboard microelectronic devices under radiation effect is the integrated microcircuits (IMC), especially of large scale (LSI) and very large scale (VLSI) degree of integration. The main characteristic of IMC, which is taken into account when making decisions on using some particular type of IMC in the onboard RED, is the probability of non-failure operation (NFO) at the end of the spacecraft’s lifetime. It should be noted that, until now, the NFO has been calculated only from the reliability characteristics, disregarding the radiation effect. This paper presents the so-called “reliability” approach to determination of radiation tolerance of IMC, which allows one to estimate the probability of non-failure operation of various types of IMC with due account of radiation-stimulated dose failures. The described technique is applied to RED onboard the Spektr-R spacecraft to be launched in 2007.     

A three-dimensional plasma and energetic particle investigation for the wind spacecraft

This instrument is designed to make measurements of the full three-dimensional distribution of suprathermal electrons and ions from solar wind plasma to low energy cosmic rays, with high sensitivity, wide dynamic range, good energy and angular resolution, and high time resolution. The primary scientific goals are to explore the suprathermal particle population between the solar wind and low energy cosmic rays, to study particle accleration and transport and wave-particle interactions, and to monitor particle input to and output from the Earth's magnetosphere.Three arrays, each consisting of a pair of double-ended semi-conductor telescopes each with two or three closely sandwiched passivated ion implanted silicon detectors, measure electrons and ions above 20 keV. One side of each telescope is covered with a thin foil which absorbs ions below 400 keV, while on the other side the incoming <400 keV electrons are swept away by a magnet so electrons and ions are cleanly separated. Higher energy electrons (up to 1 MeV) and ions (up to 11 MeV) are identified by the two double-ended telescopes which have a third detector. The telescopes provide energy resolution of E/E0.3 and angular resolution of 22.5°×36°, and full 4 steradian coverage in one spin (3 s).Top-hat symmetrical spherical section electrostatic analyzers with microchannel plate detectors are used to measure ions and electrons from 3 eV to 30 keV. All these analyzers have either 180° or 360° fields of view in a plane, E/E0.2, and angular resolution varying from 5.6° (near the ecliptic) to 22.5°. Full 4 steradian coverage can be obtained in one-half or one spin. A large and a small geometric factor analyzer measure ions over the wide flux range from quiet-time suprathermal levels to intense solar wind fluxes. Similarly two analyzers are used to cover the wide range of electron fluxes. Moments of the electron and ion distributions are computed on board.In addition, a Fast Particle Correlator combines electron data from the high sensitivity electron analyzer with plasma wave data from the WAVE experiment (Bougeretet al., in this volume) to study wave-particle interactions on fast time scales. The large geometric factor electron analyzer has electrostatic deflectors to steer the field of view and follow the magnetic field to enhance the correlation measurements.     

Response of the electron energy distribution to an artificially emitted electron beam: Apex experiment

The paper is based on the electron and ion energy spectra measurement on board the main spacecraft of the APEX mission. During the active phase of the experiment an intense electron beam was emitted from the main satellite. The basic cycle of the electron injection is formed by current pulses of different frequencies, duration and intensity. The spacecraft potential changes due to the gun operation were compensated by a low energy Xe plasma generator. The data show that the response of the environment to the beam emission depends not only on injection parameters but on the spacecraft position and orientation with respect to the magnetic field as well. The typical response is an increase of the intensity of the low energy (less than 1 keV) electrons in all directions. In addition, strong field aligned fluxes of electrons and/or ions are observed with energies below the gun energy. An attempt to classify different types of response and to find possible mechanisms which can explain the observed phenomena is made in the present paper.     

Generation of artificial ionospheric plasma density irregularities with prescribed spectra

The creation of artificial plasma density irregularities (AI) with prescribed spectra in the ionospheric heating experiments is discussed. We show that periodic successions of powerful pulses, pumped into the F-region of the ionosphere lead to obtaining AI with the controlled stationary spatial spectrum and allow us to change power low spectral index 2β at least from 2β = 2.2 to 2β = 3.4 by changing of the powerful pulse time schedule.     

Gravity effects on connective tissue biosynthesis by cultured mesenchymal cells.

Quantitative and qualitative aspects of collagen synthesis under microgravity, normal gravity and hypergravity conditions were investigated during the spacelab D-2 mission by incubating human fibroblast cultures with [3H]-proline for 0, 4, 7, 10 and 20 hours. Quantitative analysis revealed an increase of collagen synthesis under microgravity conditions, being 40% higher than 1g controls. Hypergravity samples at 1.44g, 6.6g and 10g showed a decrease in collagen synthesis with increasing g, being down to about 15% at 10g. The relative proportion of collagen from total protein synthesized, the secretion of collagen by the cells, proline hydroxylation of individual collagen alpha-chains and the relative proportions of collagens I, III and V synthesized were not affected at any of the applied conditions.     

International cooperation in assuring continuity of environmental satellite data

In the 25 years since the launch of the first weather satellite, meteorological observations from space have become an essential part of weather forecasting and global environmental monitoring. Beginning in the 1970s, constrained national budgets and the need for a coordinated approach to global satellite observing have caused satellite operators to pursue international cooperation to assure the continuity and compatibility of these systems. This article reviews current bilateral and multilateral cooperation and technical coordination in environmental satellite activities. It also explores the potential for alternative institutional arrangements for maintaining the continuity of environmental satellite data in the decades to come.     

Preliminary results of Cytos 2 experiment.

Cytos 2 experiment, carried out during the French-Soviet manned flight (July 1982), has studied the antibiotics sensitivity of bacteria cultivated in vitro during the orbital flight. The results show an increase of the antibiotics resistance and a larger thickness of the cellular envelope for the inflight cells. The increase of antibiotics resistance can be related to a stimulating effect of space on the cell growth rate or to changes of the cellular envelope structure.     

Order of magnitude analysis of convective effects in dendritic solidification

The different types of convective phenomena which may occur during the dendritic solidification of metallic alloys are discussed from an order of magnitude analysis. Bulk thermal convection and/or interdendritic solutal convection have to be considered according to the values of the experimental data. Scaling laws for the solute boundary layer resulting from bulk thermal convection have already been derived. It is shown here that the interdendritic flow depends on a solutal Grashof number Gr based on the horizontal density gradient and a characteristic length L_s which is of the order of the liquid channels width. For Gr < 1, which is generally verified in practical cases, the interdendritic flow velocity U_r is proportional to the Grashof number. This a priori law compares favorably with the results of horizontal solidification experiments where the mean interdendritic flow velocity has been estimated from the resulting measured macrosegregation. In these experiments, as well as for most horizontal dendritic solidifications of metallic alloys at 1 g, the ratio $\text{U}{}_{\mathrm{r}}\text{R}$ (R is the growth rate) is of order one. In order to cancel the interdendritic flow effects, this ratio has to be lowered by one order of magnitude. According to our analysis, this can be obtained by performing the experiments either at a slightly reduced g level (～10^?1 g), or at 1 g in a vertical stable configuration with a sufficiently low residual horizontal thermal gradient.