A model of the effects of heavy ion radiation on human tissue

In heavy ion radiotherapy and space travel humans are exposed to energetic heavy ions (C, Si, Fe and others). This type of irradiation often produces more severe biological effects per unit dose than more common X-rays. A new Monte Carlo model generates a physical space with the complex geometry of human tissue or a cell culture based model of tissue, which is affected by the passage of ionizing radiation. For irradiation, the model relies on a physical code for the ion track structure; for tissues, cellular maps are derived from two- or three-dimensional confocal microscopy images using image segmentation algorithm, which defines cells as pixilated volumes. The model is used to study tissue-specific statistics of direct ion hits and the remote ion action on cells. As an application of the technique, we considered the spatial pattern of apoptotic cells after heavy ion irradiation. The pattern of apoptosis is modeled as a stochastic process, which is defined by the action cross section taken from available experimental data. To characterize the degree of apoptosis, an autocorrelation function that describes the spatial correlation of apoptotic cells is introduced. The values of the autocorrelation function demonstrate the effect of the directionality of the radiation track on the spatial arrangements of inactivated cells in tissue. This effect is intrinsic only to high linear-energy-transfer radiation.     

Solar activity dependence of total electron content derived from GPS observations over Mbarara

Vertical total electron content (VTEC) observed at Mbarara (geographic co-ordinates: 0.60°S, 30.74°E; geomagnetic coordinates: 10.22°S, 102.36°E), Uganda, for the period 2001–2009 have been used to study the diurnal, seasonal and solar activity variations. The daily values of the 10.7 cm radio flux (F_10.7) and sunspot number (R) were used to represent Solar Extreme Ultraviolet Variability (EUV). VTEC is generally higher during high solar activity period for all the seasons and increases from 0600 h LT and reaches its maximum value within 1400 h–1500 h LT. All analysed linear and quadratic fits demonstrate positive VTEC-F_10.7 and positive VTEC-R correlation, with all fits at 0000 h and 1400 h LT being significant with a confidence level of 95% when both linear and quadratic models are used. All the fits at 0600 h LT are insignificant with a confidence level of 95%. Generally, over Mbarara, quadratic fit shows that VTEC saturates during all seasons for F_10.7 more than 200 units and R more than 150 units. The result of this study can be used to improve the International Reference Ionosphere (IRI) prediction of TEC around the equatorial region of the African sector.     

Introduction: an overview of gravity sensing, perception, and signal transduction in animals and plants.

The antiquity of biological sensitivity and response to gravity can be traced through the ubiquity of morphology, mechanisms, and cellular events in gravity sensing biological systems in the most diverse species of both plants and animals. Further, when we examine organisms at the cellular level to elucidate the molecular mechanism by which a gravitational signal is transduced into a biochemical response, the distinction between plants and animals becomes blurred.     

Changes of deoxyribonucleoprotein in the spleen, thymus and liver of rats exposed to weightlessness and artificial gravity aboard the Cosmos biosatellites

Changes of deoxyribonucleoprotein in the spleen, thymus and liver of rats exposed to wegithlessness or artifical gravity on board biosatellites Cosmos 782 and Cosmos 936 after 20 days of flight were investigated. The level of polydeoxyribonucleotides in the spleen and thymus of rats exposed during the flight to weightlessness increased 4 – 11 hours after landing, suggesting breakdown of a part of the deoxyribonucleoprotein present. The use of artifical gravity prevented this breakdown in the thymus but not in the spleen. The breakdown was accompanied in the majority of cases by a decrease in teh deoxyribonucleoprotein content. We believe the breakdown of deoxyribonucleoprotein is due to a nonspecific stress reaction to the change from the weightless state to that of terrestrial gravity during landing. The polydeoxyribonucleotide level and amount of deoxyribonucleoprotein in the majority of cases returned to normal values during the 25 days of readaptation. No substantial change of deoxyribonucleoprotein was found in the liver. The different findings in the three organs are due to the fact that breakdown of deoxyribonucleoprotein takes place in sensitive cells underlying pycnosis. These cells are found in the spleen and thymus, but not in the liver.