Skylab experiment results: hematology studies

These studies were designed and coordinated to evaluate specific aspects of man's immunologic and hematologic systems which might be altered by or respond to the space flight environment. The biochemical functions investigated included cytogenetic damage to blood cells, immune resistance to disease, regulation of plasma and red cell volumes, metabolic processes of the red blood cell, and physical chemical aspects of red blood cell functions. Only minor changes were observed in the functional capacity of erythrocytes as determined by measuring the concentrations of selected intracellular enzymes and metabolites. Tests of red cell osmotic regulation indicated some elevation in the activity of the metabolic dependent Na-K pump, with no significant alterations in the cellular Na and K concentrations or osmotic fragility. A transient shift in red cell specific-gravity profile was observed on recovery, possibly related to changes in cellular water content. Measurements of hemoconcentration (hematocrit, hemoglobin concentration, red cell count) indicated significant fluctuations postflight, reflecting observed changes in red cell mass and plasma volume. There was no apparent reticulocytosis during the 18 days following the first manned Skylab mission in spite of a significant loss in red cell mass. However, the reticulocyte count and index did increase significantly 5 to 7 days after completion of the second, longer duration, flight. There were no significant changes in either the while blood cell count or differential. However, the capacity of lymphocytes to respond to an in vitro mitogenic challenge was repressed postflight, and appeared to be related to mission duration. The cause of this repression is unknown at this time. Only minor differences were observed in plasma protein patterns. In the second mission there were changes in the proteins involved in the coagulation process which suggested a hypercoagulative condition.     

Individual differences in susceptibility to motion sickness among six Skylab astronauts

One of the Skylab experiments dealt with motion sickness, comparing susceptibility in the workshop aloft with susceptibility preflight and postflight. Tests were conducted on and after mission-day 8 (MD 8) by which time the astronauts were adapted to working conditions. Stressful accelerations were generated by requiring the astronauts, with eyes covered, to execute standardized head movements (front, back, left, and right) while in a chair that could be rotated at angular velocities up to 30 rpm. The selected endpoint was either 150 discrete head movements or a very mild level of motion sickness. In all rotation experiments aloft, the five astronauts tested (astronaut 1 did not participate) were virtually symptom free, thus demonstrating lower susceptibility aloft than in preflight and postflight tests on the ground when symptoms were always elicited. Inasmuch as the eyes were covered and the canalicular stimuli were the same aloft as on the ground, it would appear that lifting the stimulus to the otolith organs due to gravity was an important factor in reducing susceptibility to motion sickness even though the transient stimuli generated under the test conditions were substantial and abnormal in pattern. Some of the astronauts experienced motion sickness under operational conditions aloft or after splashdown, but attention is centered chiefly on symptoms manifested in zero gravity. None of the Skylab-II crew (astronauts 1 to 3) was motion sick aloft. Astronaut 6 of the Skylab-III crew (astronauts 4 to 6) experienced motion sickness within an hour after transition into orbit; this constitutes the earliest such diagnosis on record under orbital flight conditions. The eliciting stimuli were associated with head and body movements, and astronaut 6 obtained relief by avoiding such movements and by one dose of the drug combination 1-scopolamine 0.35 mg + d-amphetamine 5.0 mg. All three astronauts of Skylab-III experienced motion sickness in the workshop where astronaut 6 was most susceptible and astronaut 4, least susceptible. The higher susceptibility of SL-III crewmen in the workshop, as compared with SL-II crewmen, may be attributable to the fact that they were based in the command module less than one-third as long as SL-II crewmen. The unnatural movements, often resembling acrobatics, permitted in the open spaces of the workshop revealed the great potentialities in weightlessness for generating complex interactions of abnormal or unusual vestibular and visual stimuli. Symptoms were controlled by body restraint and by drugs, but high susceptibility to motion sickness persisted for 3 days and probably much longer; restoration was complete on MD 7. From the foregoing statements it is clear that on and after MD 8 the susceptibility of SL-II and SL-III crewmen to motion sickness under experimental conditions was indistinguishable. The role played by the acquisition of adaptation effects prior to MD 8 is less clear and is a subject to be discussed.     

Skylab experiment M-092: results of the first manned mission

Blood pressure at 30-sec intervals, heart rate, and percentage increase in leg volume continuously were recorded during a 25-min protocol in the M092 Inflight Lower Body Negative Pressure (LBNP) experiment carried out in the first manned Skylab mission. These data were collected during six tests on each crewman over a 5-month preflight period. The protocol consisted of a 5-min resting control period, 1 min at -8, 1 min at -16, 3 min at -30, 5 min at -40, and 5 min at -50 mm Hg LBNP. A 5-min recovery period followed. Inflight tests were performed at approximately 3-day intervals through the 28-day mission. Individual variations in cardiovascular responses to LBNP during the preflight period continued to be demonstrated in the inflight tests. Measurements of the calf indicated that a large volume of fluid was shifted out of the legs early in the flight and that a slower decrease in leg volume, presumably due to loss of muscle tissue, continued throughout the flight. Resting heart rates tended to be low early in the flight and to increase slightly as the flight progressed. Resting blood pressure varied but usually was characterized by slightly elevated systolic blood pressure, lower diastolic pressure, and higher pulse pressures than during preflight examinations. During LBNP inflight a much greater increase in leg volume occurred than in preflight tests. Large increases occurred even at the smallest levels of negative pressure, suggesting that the veins of the legs were relatively empty at the beginning of the LBNP. The greater volume of blood pooled in the legs was associated with greater increases of heart rate and diastolic pressure and larger falls of systolic and pulse pressure than seen in preflight tests. The LBNP protocol represented a greater stress inflight, and on three occasions it was necessary to stop the test early because of impending syncopal reactions. LBNP responses inflight appeared to predict the degree of postflight orthostatic intolerance. Postflight responses to LBNP during the first 48 hours were characterized by marked elevations of heart rate and instability of blood pressure. In addition, systolic and diastolic pressures were typically elevated considerably both at rest and also during stress. The time required for cardiovascular responses to return to preflight levels was much slower than in the case of Apollo crewmen.     

Postmission plasma volume and red-cell mass changes in the crews of the first two Skylab missions

Red-cell mass determinations were performed before and after the first two Skylab missions. The data showed a 14% mean decrease in red-cell mass after the 28-day mission and a 12% mean decrease after the 59-day mission. The red-cell mass returned to premission levels more slowly after the shorter (28-day) than after the longer mission. Plasma volume decreases were found after each mission. with the crew from the longer mission showing the greater change (13% vs. 8.4%). Postmission decreases in red-cell mass and plasma volume have been a general finding in crewmen who return from short or long spaceflight.     

Application of high-order accurate methods to solve the computational gas dynamics and aeroacoustics problems

The application of the low dissipative high-order accurate scheme for numerical solution of the Euler and Navier-Stokes equations in the two-dimensional statement is considered. The scheme of calculating space derivatives is the seven-point central-difference approximation of the fourth order with the coefficients optimized to reduce the dispersion errors. The optimized six-step Runge-Kutta method is used for evaluating the time derivatives. By means of filtration, spurious pulsations are suppressed and shocks are processed. The results of verifying the calculation scheme realized on the stationary problem of flow around the model turbine blades are presented.     

Systems for the indication and display of secondary information in avionics and autobasing complexes

We consider the peculiarities of application for the cabin indicating systems of secondary information display, formulate and systematize the compositional and technical requirements for display systems and their elements. The tendencies and lines in the development of head-up displays for avionics and autobasing complexes were determined. The technique of calculating optics of such display systems with the use of electronic distortion compensation is presented.     

A new global version of M(3000)F2 prediction model based on artificial neural networks

A new version of global empirical model for the ionospheric propagation factor, M(3000)F2 prediction is presented. Artificial neural network (ANN) technique was employed by considering the relevant geophysical input parameters which are known to influence the M(3000)F2 parameter. This new version is an update to the previous neural network based M(3000)F2 global model developed by Oyeyemi et al. (2007), and aims to address the inadequacy of the International Reference Ionosphere (IRI) M(3000)F2 model (the International Radio Consultative Committee (CCIR) M(3000)F2 model). The M(3000)F2 has been found to be relatively inaccurate in representing the diurnal structure of the low latitude region and the equatorial ionosphere. In particular, the existing hmF2 IRI model is unable to reproduce the sharp post-sunset drop in M(3000)F2 values, which correspond to a sharp post-sunset peak in the peak height of the F2 layer, hmF2. Data from 80 ionospheric stations globally, including a good number of stations in the low latitude region were considered for this work. M(3000)F2 hourly values from 1987 to 2008, spanning all periods of low and high solar activity were used for model development and verification process. The ability of the new model to predict the M(3000)F2 parameter especially in the low latitude and equatorial regions, which is known to be problematic for the existing IRI model is demonstrated.     

Rocket berthing to an asteroid: Design problems

The results of research in a process of a probe rocket berthing to an asteroid are presented. Control laws were obtained as solutions of three problems, namely berthing considering transient processes in a rocket engine, fastest berthing with regard to fuel consumption and berthing in a scheduled time considering fuel consumption. A program trajectory obtained at solving of the first problem is suitable for mathematical modeling of berthing with the feedback control law and stabilization of angular motion. The solutions of the problems are reduced to simple formulas for controlling parameters calculation in the corresponding structures of control laws. The results can be applied in designing promising space vehicles intended for berthing to other space objects.     

Spherical accretion of massive black holes: A model for galactic nuclei

The possibility of explaining the continuous emission of active galactic nuclei in the frame of a model of spherical accretion onto a massive black hole is discussed. Cool inhomogeneities (T 10⁴°K) within the accretion flow could be responsible for the broad line emission if half of the accreting matter is in the dense phase. A crucial test of this hypothesis is the expected correlation between the ratio of the luminosity in lines to the total luminosity and the hardness of the continuous spectrum.