Terahertz circular dichroism spectroscopy: a potential approach to the in situ detection of life's metabolic and genetic machinery

We propose a terahertz (far-infrared) circular dichroism-based life-detection technology that may provide a universal and unequivocal spectroscopic signature of living systems regardless of their genesis. We argue that, irrespective of the specifics of their chemistry, all life forms will employ well-structured, chiral, stereochemically pure macromolecules (>500 atoms) as the catalysts with which they perform their metabolic and replicative functions. We also argue that nearly all such macromolecules will absorb strongly at terahertz frequencies and exhibit significant circular dichroism, and that this circular dichroism unambiguously distinguishes biological from abiological materials. Lastly, we describe several approaches to the fabrication of a terahertz circular dichroism spectrometer and provide preliminary experimental indications of their feasibility. Because terahertz circular dichroism signals arise from the molecular machinery necessary to carry out life's metabolic and genetic processes, this life-detection method differs fundamentally from more well-established approaches based on the detection of isotopic fractionation, "signature" carbon compounds, disequilibria, or other by-products of metabolism. Moreover, terahertz circular dichroism spectroscopy detects this machinery in a manner that makes few, if any, assumptions as to its chemical nature or the processes that it performs.     

Solar particle event dose distributions: parameterization of dose-time profiles

Calculations of total dose and dose equivalent as a function of time since the start of the event are presented for four of the major solar particle events that occurred during the period from August to December 1989. Results are presented for exposures to the skin, ocular lens and bone marrow shielded by a nominal thickness of aluminum shielding, comparable to that provided by a spacesuit. The calculated curves of organ dose and dose equivalent versus time are parameterized using a Weibull functional form for the fitting equation. The fitting parameters are determined using least squares regression techniques. These results provide a useful starting point for the development of methods to predict the cumulative doses and times to reach various dose limits from a limited number of dose measurements early in a solar particle event.     

Adaptation of neuromuscular activation patterns during treadmill walking after long-duration space flight

The precise neuromuscular control needed for optimal locomotion, particularly around heel strike and toe off, is known to he compromised after short duration (8- to 15-day) space flight. We hypothesized here that longer exposure to weightlessness would result in maladaptive neuromuscular activation during postflight treadmill walking. We also hypothesized that space flight would affect the ability of the sensory-motor control system to generate adaptive neuromuscular activation patterns in response to changes in visual target distance during postflight treadmill walking. Seven crewmembers, who completed 3- to 6-month missions, walked on a motorized treadmill while visually fixating on a target placed 30 cm (NEAR) or 2 m (FAR) from the subject's eyes. Electronic foot switch data and surface electromyography were collected from selected muscles of the right lower limb. Results indicate that the phasic features of neuromuscular activation were moderately affected and the relative amplitude of activity in the tibialis anterior and rectus femoris around toe off changed after space flight. Changes also were evident after space flight in how these muscles adapted to the shift in visual target distance.     

The Huygens Doppler Wind Experiment ' Titan Winds Derived from Probe Radio Frequency Measurements

A Doppler Wind Experiment (DWE) will be performed during the Titan atmospheric descent of the ESA Huygens Probe. The direction and strength of Titan's zonal winds will be determined with an accuracy better than 1 m s⁻¹ from the start of mission at an altitude of ∼160 km down to the surface. The Probe's wind-induced horizontal motion will be derived from the residual Doppler shift of its S-band radio link to the Cassini Orbiter, corrected for all known orbit and propagation effects. It is also planned to record the frequency of the Probe signal using large ground-based antennas, thereby providing an additional component of the horizontal drift. In addition to the winds, DWE will obtain valuable information on the rotation, parachute swing and atmospheric buffeting of the Huygens Probe, as well as its position and attitude after Titan touchdown. The DWE measurement strategy relies on experimenter-supplied Ultra-Stable Oscillators to generate the transmitted signal from the Probe and to extract the frequency of the received signal on the Orbiter. Results of the first in-flight checkout, as well as the DWE Doppler calibrations conducted with simulated Huygens signals uplinked from ground (Probe Relay Tests), are described. Ongoing efforts to measure and model Titan's winds using various Earth-based techniques are briefly reviewed. This revised version was published online in August 2006 with corrections to the Cover Date.     

Geometric accuracy in airborne SAR images

Uncorrected across-track motions of a synthetic aperture radar (SAR) platform can cause both a severe loss of azimuthal positioning accuracy in, and defocusing of, the resultant SAR image. It is shown how the results of an autofocus procedure can be incorporated in the azimuth processing to produce a fully focused image that is geometrically accurate in azimuth. Range positioning accuracy is also discussed, leading to a comprehensive treatment of all aspects of geometric accuracy. The system considered is an X-band SAR     

Range-Doppler Imaging with Motion through Resolution Cells

Doppler processing in pulsed radar is analyzed for time intervals which involve motion through range resolution cells, the emphasis being on the range-Doppler imaging of a rigid rotating body. The objective of the theory is to derive a method for compensating for motion through range and cross-range resolution cells. The compensation ion procedure described is compatible with optical data processing. With such a two-dimensional processor, the method permits simultaneous eous compensation for all points in the target field. The s consists of taking the Fourier transform in the range dimension, followed by a gentle distortion of this range-transform plane, and that followed by a two-dimensional Fourier transform. Two implementations with experimental results are briefly mentioned. One implementation is all optical and utilizes a holographic hyperbolic lens and/or holographic conical lens. The other implementation, involves applying the appropriate te distortion electronically as th " range sweeps" from the pulse train are received and put on film.     

窗外迎面风引起的多层建筑火灾流场特性

从理论上研究了不同楼层，位于楼房边侧或中间不同位置的房间发生火灾时，外界吹来正向的不同风速，对房间内外稳态温度场与流场的作用。特别研究了房间内热气流流出窗外向上运动的浮力和外界风力相互作用发生的现象及其对房间内流动的影响，引入了关于风的临界速度（或流量），作为外界风速与建筑物内火灾流场相互作用有标志性的重要参数，本文还对不同外界风速情况下，房间内外速度中性面倾斜的角度，房间内流出热气流温度的差别等诸多问题进行了详细的讨论。     

Evaluating the Detectability of Gaussian Stochastic Signals by Steepest Descent Integration

It is shown how to compute the detection probability of certain signals by numerical integration of the Laplace inversion integral involving the characteristic function or the moment-generating function of the detection statistic. The contour of integration is taken as the path of steepest descent of the integrand and is determined numerically as the integration proceeds. The method is applied to calculating the performance of the optimum detector of a Gaussian stochastic signal in white noise when the signals actually present have a different average s.n.r. from that assumed in the design. Results are presented for narrowband signals with Lorentz and rectangular spectral densities. The detectability of the former is shown to be more sensitive than that of the latter to the value of the design s.n.r. The relative disadvantage of the threshold detector, also assessed by this method, is smaller for signals with a rectangular than for those with a Lorentz spectral density.     

Implementing digital terrain data in knowledge-aided space-time adaptive processing

Many practical problems arise when implementing digital terrain data in airborne knowledge-aided (KA) space-time adaptive processing (STAP). This paper addresses these issues and presents solutions with numerical implementations. In particular, using digital land classification data and digital elevation data, techniques are developed for registering these data with radar return signals, correcting for Doppler and spatial misalignments, adjusting for antenna gain, characterizing clutter patches for secondary data selection, and ensuring independent secondary data samples. These techniques are applied to select secondary data for a single-bin post-Doppler STAP algorithm using multi-channel airborne radar measurement (MCARM) program data. Results with the KA approach are compared with those obtained using the standard sliding window method for choosing secondary data. These results illustrate the benefits of using terrain information, a priori data about the radar, and the importance of statistical independence when selecting secondary data for improving STAP performance     

Spatio-temporal pattern recognition using hidden Markov models

A spatio-temporal method for identifying objects contained in an image sequence is presented. The Hidden Markov Model (HMM) technique is used as the classification algorithm, making classification decisions based on a spatio-temporal sequence of observed object features. A five class problem is considered. Classification accuracies of 100% and 99.7%, are obtained for sequences of images generated over two separate regions of viewing positions. HMMs trained on image sequences of the objects moving in opposite directions showed a 98.1% successful classification rate by class and direction of movement. The HMM technique proved robust to image corruption with additive correlated noise and had a higher accuracy than a single-look nearest neighbor method. A real image sequence of one of the objects used was successfully recognized with the HMMs trained on synthetic data. This study shows the temporal changes that observed feature vectors undergo due to object motion hold information that can yield superior classification accuracy when compared with single-frame techniques