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41.
Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation. 总被引:3,自引:0,他引:3
T K Hei Y L Zhao D Roy C Q Piao G Calaf E J Hall 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2001,27(2):411-419
Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process. 相似文献
42.
Khan M.H. Le-Ngoc T. Bhargava V.K. 《IEEE transactions on aerospace and electronic systems》1985,(4):547-558
Two hybrid schemes of time-frequency resource sharing to increase the rain margin of Ku-and Ka-band satellite systems are proposed. Scheme 1 requires sharing a small pool of bandwidth for adaptive forward error control coding, sharing a small pool of time frame for rate reduction, and sharing a portion of low frequency time-division multiple access (TDMA) back-up frame for downlink transmission to the rain affected stations. Scheme 2 utilizes variable rate modulation and forward error correction, shares a small pool of time frame for rate reduction, and shares a portion of low frequency TDMA back-up frame. Effective usable capacities of the system using these schemes are calculated. Distribution of resources in order to maximize the effective usable capacity is also analyzed. The results obtained are compared with other adaptive schemes. Preliminary analysis shows that the utilized capacity of scheme 1 exceeds 99 percent of the effective usable capacity possible if it never rains for an outage of 0.05 percent and fade margin of 2.5 dB. For scheme 2 similar performance is achievable at a fade margin of 1.5 dB. For higher outage objectives the loss of effective utilized capacity is higher for scheme 2. 相似文献
43.
R D Govorun I V Koshlan N A Koshlan E A Krasavin N L Shmakova 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2002,30(4):885-890
The induction of HPRT-mutations and survival of Chinese hamster cells (line B11ii-FAF28, clone 431) were studied after irradiation by 4He and 12C-ions of various LET (20-360 keV/micrometers), produced by the U-200 heavy ion accelerator. The RBE increases with LET up to the maximum at 100-200 keV/micrometers and then decreases. Cytogenetic analysis was performed on the HPRT-mutant subclones selected from unirradiated Chinese hamster V-79 cells and from HPRT-mutant subclones that arose after exposure to gamma-rays, 1 GeV protons and 14N-ions (LET-77 keV/micrometers), produced by the synchrophasotron and the U-400M heavy ion accelerator. Slow growing mutant subclones were observed. The cytogenetic properties of individual clones were highly heterogeneous and chromosome instability was observed in both spontaneous and radiation-induced mutants. Chromosome instability was highest among spontaneous mutants and decreased with increasing LET. 相似文献
44.
Kottaras G. Sarris E. Paschalidis B. Stamatopoulos N. Paschalidis N. 《IEEE transactions on aerospace and electronic systems》2004,40(3):862-878
Several design and testing aspects of the TRIO smart sensor data acquisition chip, developed by JHU/APL for NASA spacecraft applications are presented. TRIO includes a 10 bit self-corrected analog-to-digital converter (ADC), 16/32 analog inputs, a front end multiplexer with selectable aquisition time, a current source, memory, serial and parallel bus, and control logic. So far TRIO is used in many missions including Contour, Messenger, Stereo, Pluto, and the generic JPL X2000 spacecraft bus. 相似文献
45.
V. Koblik E. Polyakhova L. Sokolov A. Shmyrov 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2002,29(12):4431-2088
We present results of numerical simulations of trajectories of a space probe with a flat solar sail which moves from a circular Earth orbit to near-Sun regions. We consider the upper limit of the sail temperature as the basic restriction. We also examine the planar (ecliptic) solar sail transfer with gravity-assist flybys around planets. 相似文献
46.
47.
G Horneck R Facius G Reitz P Rettberg C Baumstark-Khan R Gerzer 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2003,31(1):87-95
Human missions to Mars are planned to happen within this century. Activities associated therewith will interact with the environment of Mars in two reciprocal ways: (i) the mission needs to be protected from the natural environmental elements that can be harmful to human health, the equipment or to their operations; (ii) the specific natural environment of Mars should be protected so that it retains its value for scientific and other purposes. The following environmental elements need to be considered in order to protect humans and the equipment on the planetary surface: (i) cosmic ionizing radiation, (ii) solar particle events; (iii) solar ultraviolet radiation; (iv) reduced gravity; (v) thin atmosphere; (vi) extremes in temperatures and their fluctuations; and (vii) surface dust. In order to protect the planetary environment, the requirements for planetary protection as adopted by COSPAR for lander missions need to be revised in view of human presence on the planet. Landers carrying equipment for exobiological investigations require special consideration to reduce contamination by terrestrial microorganisms and organic matter to the greatest feasible extent. Records of human activities on the planet's surface should be maintained in sufficient detail that future scientific experimenters can determine whether environmental modifications have resulted from explorations. 相似文献
48.
The governments’ priority and budgets for space activities are steadily decreasing and the importance of space activities is not any longer reaching the front pages of the newspaper, as in the 1960s. On the other hand in Europe the people, at large, have shown an important interest and support for space activities. A contribution to bridge the gap between decreasing funding and important support of citizen can come from teaching space policy in universities as well as in special workshops for government, industrial and military circles. The paper will outline a course that fulfils this goal. 相似文献
49.
G. Sachs 《Aerospace Science and Technology》2003,7(8):160-631
A longitudinal-lateral control coordination and simplification concept is considered for a tunnel/predictor display, which presents the command flight path and a specified future aircraft position in a 3-dimensional format to the pilot, for improving flight path control. A basic element of the proposed concept is the generation of common longitudinal-lateral transfer characteristics of the predictor-aircraft system for the crossover frequency region. Control coordination is supported by a dynamics similarity between the longitudinal and the lateral response characteristics of the predictor position in closed-loop pilot control actions. The control coordination and simplification concept is considered to support the pilot in manual flight path control, directed at an enhancement of his control performance and at a reduction of his workload. Results from pilot-in-the-loop simulation experiments support the theoretical findings and show the effectiveness of the proposed predictor concept with control coordination. 相似文献
50.
F. S. Khairullin 《Russian Aeronautics (Iz VUZ)》2009,52(4):480-483
We consider a possibility to apply the method of analyzing the complex-shaped shells, proposed in [1], for determining the
stress strain state of thin shells with a degenerating domain. The results of numerical calculations are presented. 相似文献