The role of DNA repair on cell killing by charged particles.

It can be noted that it is not simple double strand breaks (dsb) but the non-reparable breaks that are associated with high biological effectiveness in the cell killing effect for high LET radiation. Here, we have examined the effectiveness of fast neutrons and low (initial energy = 12 MeV/u) or high (135 MeV/u) energy charged particles on cell death in 19 mammalian cell lines including radiosensitive mutants. Some of the radiosensitive lines were deficient in DNA dsb repair such as LX830, M10, V3, and L5178Y-S cells and showed lower values of relative biological effectiveness (RBE) for fast neutrons if compared with their parent cell lines. The other lines of human ataxia-telangiectasia fibroblasts, irs 1, irs 2, irs 3 and irs1SF cells, which were also radiosensitive but known as proficient in dsb repair, showed moderated RBEs. Dsb repair deficient mutants showed low RBE values for heavy ions. These experimental findings suggest that the DNA repair system does not play a major role against the attack of high linear energy transfer (LET) radiations. Therefore, we hypothesize that a main cause of cell death induced by high LET radiations is due to non-reparable dsb, which are produced at a higher rate compared to low LET radiations.     

Austrian dose measurements onboard space station MIR and the International Space Station--overview and comparison.

The Atominstitute of the Austrian Universities has conducted various space research missions in the last 12 years in cooperation with the Institute for Biomedical Problems in Moscow. They dealt with the exact determination of the radiation hazards for cosmonauts and the development of precise measurement devices. Special emphasis will be laid on the last experiment on space station MIR the goal of which was the determination of the depth distribution of absorbed dose and dose equivalent in a water filled Phantom. The first results from dose measurements onboard the International Space Station (ISS) will also be discussed. The spherical Phantom with a diameter of 35 cm was developed at the Institute for Biomedical Problems and had 4 channels where dosimeters can be exposed in different depths. The exposure period covered the timeframe from May 1997 to February 1999. Thermoluminescent dosimeters (TLDs) were exposed inside the Phantom, either parallel or perpendicular to the hull of the spacecraft. For the evaluation of the linear energy transfer (LET), the high temperature ratio (HTR) method was applied. Based on this method a mean quality factor and, subsequently, the dose equivalent is calculated according to the Q(LET infinity) relationship proposed in ICRP 26. An increased contribution of neutrons could be detected inside the Phantom. However the total dose equivalent did not increase over the depth of the Phantom. As the first Austrian measurements on the ISS dosimeter packages were exposed for 248 days, starting in February 2001 at six different locations onboard the ISS. The Austrian dosimeter sets for this first exposure on the ISS contained five different kinds of passive thermoluminescent dosimeters. First results showed a position dependent absorbed dose rate at the ISS.     

A wavelet multiresolution analysis for spatio-temporal signals

The wavelet filters of the conventional 3D multiresolution analysis possess homogeneous spatial and temporal frequency characteristics which limits one's ability to match filter frequency characteristics to signal frequency behavior. Also, the conventional 3D multiresolution analysis employs an oct-tree decomposition structure which restricts the analysis of signal details to identical resolutions in space and time. This paper presents a 3D wavelet multiresolution analysis constructed from nonhomogeneous spatial and temporal filters, and an orthogonal sub-band coding scheme that decouples the spatial and temporal decomposition processes     

Simulation of fast ablation

A brief review of studies on simulation and control of a porous cooling process taking into account material transpiration is given. An approximated solution for an equation of the one-dimensional problem of fast ablation is also presented.     

The finite element analysis of shells of revolution with a branching meridian

We present an algorithm for calculating the shells of revolution with the branching meridian using the triangular finite elements, the rigidity matrices of which are formed based on the vector method of displacement interpolation [1]. The correct kinematic and static conditions of shell conjugation on the line of their coupling have been developed. The shell structure consisting of a cylinder and adjacent shells is calculated under various conditions of support.     

Recent Breakthroughs in RF Photonics for Radar Systems

Radar systems require transmission of very high purity signals. Photonics is now mature enough to achieve analog transmission with very low noise, strong immunity, and wide-bandwidth even in harsh environments. We present our recent developments of optimized optical links dedicated to radar and multifunction systems     

Wireless interconnection to test instruments

Manufacturers are increasingly offering Ethernet connectivity on their test instruments. An additional benefit of this connection method is the ease of conversion to wireless connectivity. This paper describes the Ethernet interface used in the remote control of a RF power amplifier and describes the conversion to wireless connection.     

Optimal number of phased array faces and signal processors for horizon surveillance

The problem of the optimal number of phased array faces for performing 360/spl deg/ horizon surveillance is considered. Assuming the detection performance is the same in all beam positions and the total number of T/R modules is constant, it is shown that the optimal number of array faces is three. This is true whether the arrays are operating simultaneously or sequentially. A parametric analysis is performed between the number of array faces operating simultaneously and the associated cost of simultaneous operation in terms of the size of the array.     

Distributed decision fusion using empirical estimation

The problem of optimal data fusion in multiple detection systems is studied in the case where training examples are available, but no a priori information is available about the probability distributions of errors committed by the individual detectors. Earlier solutions to this problem require some knowledge of the error distributions of the detectors, for example, either in a parametric form or in a closed analytical form. Here we show that, given a sufficiently large training sample, an optimal fusion rule can be implemented with an arbitrary level of confidence. We first consider the classical cases of Bayesian rule and Neyman-Pearson test for a system of independent detectors. Then we show a general result that any test function with a suitable Lipschitz property can be implemented with arbitrary precision, based on a training sample whose size is a function of the Lipschitz constant, number of parameters, and empirical measures. The general case subsumes the cases of nonindependent and correlated detectors.     

Problem of precision missile guidance: LQR and H/sup /spl infin// control frameworks

Addressed here is the precision missile guidance problem where the successful intercept criterion has been defined in terms of both minimizing the miss distance and controlling the missile body attitude with respect to the target at the terminal point. We show that the H/sup /spl infin// control theory, when suitably modified, provides an effective framework for the precision missile guidance problem. The existence of feedback controllers (guidance laws) is investigated for the case of finite horizon and non-zero initial conditions. Both state feedback and output feedback implementations are explored.