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481.
    
High-affinity Na+-dependent glutamate transporters of the plasma membrane mediate the glutamate uptake into neurons, and thus maintain low levels of extracellular glutamate in the synaptic cleft. The study focused on the release of glutamate by reversal of Na+-dependent glutamate transporters from rat brain nerve terminals (synaptosomes) under conditions of centrifuge-induced hypergravity. Flow cytometric analysis revealed similarity in the size and cytoplasmic granularity between synaptosomal preparations obtained from control and G-loaded animals (10 G, 1 h). The release of cytosolic l-[14C]glutamate from synaptosomes was evaluated using the protonophore FCCP, which dissipated synaptic vesicle proton gradient, thus synaptic vesicles were not able to keep glutamate inside and the latter enriched cytosol. FCCP per se induced the greater release of l-[14C]glutamate in hypergravity as compared to control (4.8 ± 1.0% and 8.0 ± 1.0% of total label). Exocytotic release of l-[14C]glutamate evoked by depolarization was reduced down to zero after FCCP application under both conditions studied. Depolarization stimulated release of cytosolic l-[14C]glutamate from synaptosomes preliminary treated with FCCP was considerably increased from 27.0 ± 2.2% of total label in control to 35.0 ± 2.3% in hypergravity. Non-transportable inhibitor of glutamate transporter dl-threo-β-benzyloxyaspartate was found to significantly inhibit high-KCl and FCCP-stimulated release of l-[14C]glutamate, confirming the release by reversal of glutamate transporters. The enhancement of transporter-mediated release of glutamate in hypergravity was found to result at least partially from the inhibition of the activity of Na/K-ATPase in the plasma membrane of synaptosomes. We suggested that hypergravity-induced alteration in transporter-mediated release of glutamate indicated hypoxic injury of neurons.  相似文献   
482.
483.
    
The Global Positioning System (GPS) Radio Occultation (RO) technique has global coverage and is capable of generating high vertical resolution temperature profiles of the upper troposphere and lower stratosphere with sub-Kelvin accuracy and long-term stability, regardless of weather conditions. In this work, we take advantage of the anomalously high density of occultation events at the eastern side of the highest Andes Mountains during the initial mission months of COSMIC (Constellation Observing System for Meteorology, Ionosphere and Climate). This region is well-known for its high wave activity. We choose to study two pairs of GPS RO, both containing two occultations that occurred close in time and space. One pair shows significant differences between both temperature profiles. Numerical simulations with a mesoscale model were performed, in order to understand this discrepancy. It is attributed to the presence of a horizontal inhomogeneous structure caused by gravity waves.  相似文献   
484.
Marchi  S.  Asphaug  E.  Bell  J. F.  Bottke  W. F.  Jaumann  R.  Park  R. S.  Polanskey  C. A.  Prettyman  T. H.  Williams  D. A.  Binzel  R.  Oran  R.  Weiss  B.  Russell  C. T. 《Space Science Reviews》2022,218(4):1-28
Space Science Reviews - Analysis of Homestake, Gallex and GNO measurements reveals evidence of variability of presumed solar-neutrino-flux measurements. Analysis of Super-Kamiokande neutrino...  相似文献   
485.
Simultaneous observations of in situ plasma properties in the tail of the Earth’s magnetosphere and of ground based instruments, lying on the same geomagnetic field lines, have recently proved to yield significant new results. In most cases magnetosphere ionosphere interactions during the night-time northern hemisphere conditions are studied. Here, observations of energetic electrons in the tail of the Earth’s magnetosphere made by the THEMIS mission satellites are compared with auroral radio wave absorption determined by riometers in the Antarctic for sunlit conditions. Days for which satellites and riometers are connected by the same geomagnetic field line are selected using a geomagnetic field model. The six days analysed show clear associations between fluxes and absorptions in some cases. However, these do not necessarily correspond to conjugacy intervals. Hours of positive associations are 1.65 times those for negative associations, all hours and days considered (1.42–3.6 on five days and 0.58 on the other day). These computations are assumed appropriate since the footprints of the satellites used approximately follow corrected geomagnetic parallels for all six days studied. The use of a finer parameterization of geomagnetic models to determine conjugacy may be needed.  相似文献   
486.
An analysis is presented that forms the basis for an algorithm for calculating the IGBT losses in a power factor correction (PFC) circuit. The method employs experimental data from an off-line test circuit that closely resembles the switching conditions in the actual PFC. This technique provides calculated values of both the conduction and switching losses of the main transistor in a boost-type PFC circuit. Results for a 6 kW PFC are included  相似文献   
487.
    
A formula is derived for interpolation between output samples of a fast Fourier transform (FFT), i.e., in the frequency domain. Such a formula is useful for obtaining greater frequency resolution when two coarse FFT outputs are available. Consideration is also given to the effect of such interpolation on a weighted FFT.  相似文献   
488.
    
The comparison of the IRI model with the foF2 distribution in the equatorial anomaly region obtained by topside sounding onboard the Interkosmos-19 satellite has been carried out. The global distribution of foF2 in terms of LT-maps was constructed by averaging Intercosmos-19 data for summer, winter, and equinox. These maps, in fact, represent an empirical model of the equatorial anomaly for high solar activity F10.7 ~ 200. The comparison is carried out for the latitudinal foF2 profiles in the characteristic longitudinal sectors of 30, 90, 210, 270, and 330°, as well as for the longitudinal variations in foF2 over the equator. The largest difference between the models (up to 60%) for any season was found in the Pacific longitudinal sector of 210°, where there are a few ground-based sounding stations. Considerable discrepancies, however, are sometimes observed in the longitudinal sectors, where there are many ground-based stations, for example, in the European or Indian sector. The discrepancies reach their maximum at 00 LT, since a decay of the equatorial anomaly begins before midnight in the IRI model and after midnight according to the Interkosmos-19 data. The discrepancies are also large in the morning at 06 LT, since in the IRI model, the foF2 growth begins long before sunrise. In the longitudinal variations in foF2 over the equator at noon, according to the satellite data, four harmonics are distinguished in the June solstice and at the equinox, and three harmonics in the December solstice, while in the IRI model only two and one harmonics respectively are revealed. In diurnal variations in foF2 and, accordingly, in the equatorial anomaly intensity, the IRI model does not adequately reproduce even the main, evening extremum.  相似文献   
489.
Based on Polar satellite data, the authors have studied the auroral disturbances that arose during the passage by the Earth of compressed plasma regions formed in front of high-speed solar wind streams (the CIR region) and in front of magnetic clouds (the Sheath region). The aurorae observed by the Polar satellite possessed basic signatures of a substorm: a localized onset and expansion toward the pole and westward and eastward. However, in these cases they had a very large size in longitude and latitude and occupied a very large area. All disturbances observed by the Polar satellite during the Sheath and CIR regions of the solar wind in December of 1996, in 1997–1998, and in 2000 were analyzed. Eight events during disturbance development in the ionosphere, when the Geotail satellite was located in the plasma sheet of the magnetospheric tail, were selected. It is shown that in all selected cases some typical signatures of substorm development in the magnetospheric tail were observed, namely: (1) fast plasma flows (flow reversal, i.e., from tailwards to Earthwards) and (2) a sharp decrease of the total pressure, which followed an interval of total pressure increase. One can draw the conclusion that in the CIR and Sheath regions with a high solar wind density, substorm disturbances of a specific type are observed, with large latitudinal and longitudinal size (sometimes occupying the entire polar cap).  相似文献   
490.
Mathematical representations of a state-plane switching boundary employed in a state-trajectory control law for dc-to-dc converters are derived. Several levels of approximation to the switching boundary equations are presented, together with an evaluation of the effects of nonideal operating characteristics of converter power stage components on the shape and location of the boundary and the behavior of a system controlled by it. Digital computer simulations ions of d-to-dc converters operating in conjunction with each of these levels of control are presented and evaluated with respect to changes in transient and steady-state performance.  相似文献   
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