Usefulness of daily +2Gz load as a countermeasure against physiological problems during weightlessness.

Adaptation to head-down-tilt bed rest as a simulated microgravity leads to an abnormality of reflex control of circulation, hypovolemia and reduction of exercise capacity. We hypothesized that this cardiovascular deconditioning and reduction of exercise capacity could be prevented by a daily 1 hr centrifugation at +2Gz. To test this hypothesis, twenty healthy male subjects underwent 4 day of 6 degrees head-down-tilt bed rest. Ten of them were exposed to a +2Gz load for up to 30 min twice per day (the Gz group). The remaining 10 were not exposed to a Gz load (the no-Gz group). We estimated autonomic cardiovascular control by power spectral analysis of blood pressure and R-R interval variability, and baroreflex regulation by the transfer function analysis and the sequence method, before and after bed rest. Further, we measured hematocrit as an index of changes in plasma volume and maximal oxygen consumption as an index of exercise capacity, before and after bed rest. Result: In the no-Gz group, heart rate increased after bed rest. The high frequency power of R-R interval variability as an index of cardiac parasympathetic nervous activity, baroreflex gains estimated by transfer function analysis and the sequence method as index of the integrated arterial-cardiac baroreflex function decreased significantly. Associated with these changes, the ratio of low to high frequency power of R-R as an indicator of cardiac sympathovagal balance tended to increase after bed rest in the no-Gz group. However, those showed no significant changes after bed rest in the Gz group. Hematocrit increased after bed rest in the no-Gz group. It also tended to increase in the Gz group, however it did not achieve statistical significance. Maximal oxygen consumption decreased significantly to similar extent in both the groups. Conclusion: This result suggested that 1) a daily 1hr +2Gz load produced by a centrifuge might eliminate the changes in autonomic cardiovascular control during simulated weightlessness; 2) furthermore, it might partly reverse hypovolemia induced by bed rest; 3) however, it could not prevent the decreases in exercise capacity.     

Neuritogenesis: a model for space radiation effects on the central nervous system.

Pivotal to the astronauts' functional integrity and survival during long space flights are the strategies to deal with space radiations. The majority of the cellular studies in this area emphasize simple endpoints such as growth related events which, although useful to understand the nature of primary cell injury, have poor predictive value for extrapolation to more complex tissues such as the central nervous system (CNS). In order to assess the radiation damage on neural cell populations, we developed an in vitro model in which neuronal differentiation, neurite extension, and synaptogenesis occur under controlled conditions. The model exploits chick embryo neural explants to study the effects of radiations on neuritogenesis. In addition, neurobiological problems associated with long-term space flights are discussed.     

Local-area helioseismology as a diagnostic tool for solar variability

Dynamical and thermal variations of the internal structure of the Sun can affect the energy flow and result in variations in irradiance at the surface. Studying variations in the interior is crucial for understanding the mechanisms of the irradiance variations. “Global” helioseismology based on analysis of normal mode frequencies, has helped to reveal radial and latitudinal variations of the solar structure and dynamics associated with the solar cycle in the deep interior. A new technique, - “local-area” helioseismology or heliotomography, offers additional potentially important diagnostics by providing three-dimensional maps of the sound speed and flows in the upper convection zone. These diagnostics are based on inversion of travel times of acoustic waves which propagate between different points on the solar surface through the interior. The most significant variations in the thermodynamic structure found by this method are associated with sunspots and complexes of solar activity. The inversion results provide evidence for areas of higher sound speed beneath sunspot regions located at depths of 4–20 Mm, which may be due to accumulated heat or magnetic field concentrations. However, the physics of these structures is not yet understood. Heliotomography also provides information about large-scale stable longitudinal structures in the solar interior, which can be used in irradiance models. This new diagnostic tool for solar variability is currently under development. It will require both a substantial theoretical and modeling effort and high-resolution data to develop new capabilities for understanding mechanisms of solar variability.     

Implementation of a new characteristic parameter into the IRI sub-peak electron density profile

The shape of electron density profile in the International Reference Ionosphere could be improved significantly if the height h_g and electron density N_g of the F region sub-peak inflexion point were entered in the set of the profile standard parameters. To study variations of these important parameters, the N(h) analysis of the statistically-summarized ionograms at the latitudes of 40–80°N of the Eastern hemisphere has been carried out for the two-hours intervals of local time, three seasons (winter, equinox and summer) and two levels of solar activities characterized by Covington indicesF_10.7 = 100 and 200. It is shown that the parameters of the inflexion point can be expressed in most cases via the peak parameters of the F2 layer ash_g= 0.8 hmF2 and N_g= 0.5 NmF2.     

The instrument IKS and its calibration

The IKS infrared spectro-photometer will fly on board the VEGA platforms. It is designed to characterize the size, temperature and emissivity of the Comet Halley nucleus, to identify the major gaseous components of the inner coma and to detect the emission of the cometary grains. This paper presents the “calibration” experiments required to reduce the raw data: (i) absolute wavelength calibration of the filter wheels; (ii) modeling of the internal signal, as a function of the temperature of the different sub-systems; (iii) absolute and spectral responsivities of each of the spectrometric and photometric channels, as a function of the wavelength and position of the source in the field of view. Finally, we shall indicate the expected S/N ratios.     

Adaptive Array Bandwidth with Tapped Delay-Line Processing

The bandwidth of adaptive arrays with tapped delay lines behind the elements is examined. Such processing offers improved bandw over that attainable with quadrature hybrid processing. The performance of a two-element array with four types of processing (equarature hybrids, single delay lines, 3-tap delay lines, and 5-tap delay lines) is compared. It is shown that with half-wavelength element spacing, a quadrature hybrid and single delay-line processor are inadequate at 10-percent bandwidth. A 3-tap processor is adeq however, up to 40-percent bandwidth.     

The microlesion concept in HZE particle dosimetry.

High energy, high-Z (HZE) particles are present in high-altitude and high-inclination satellite orbits. Most of the HZE dose above LET = 200 keV/micrometer is due to Fe nuclei. Individual HZE particles can damage several cells adjacent to one another along the particle track in tissue. The outcome has been described as a "microlesion" by D. Grahn. The present study attempts to define conditions for microlesions in specific tissues, to seek biological evidence that microlesions are produced, and to evaluate the microlesion as a potentially useful unit of dose in assessing hazards to spaceworkers. Microlesions in individuals cells and hair follicles have been described. Microbial studies have provided some evidence for independent secondary electron action. Whether or not a few hundred microlesions would be damaging to the whole organism depends upon the nature of damage to critical tissues. For example, cancer may occur if microlesions kill several cells in a straight line and mutate other cells alongside the particle track. Fe particle irradiation of the mouse Harderian gland (Fry et al., this issue) produces tumors efficiently. Microlesions in the lens, cornea, and retina need to be considered. Further dialogue is required before a final decision can be made concerning the most appropriate way to assess the HZE hazard.     

GPS Aided Inertial Navigation

The Global Positioning System is an extremely accurate satellite-based navigation system which, after its completion in 1989, will provide users worldwide, 24 hour. all weather coverage. A joint research project among Boeing, Rockwell-Collins, and Northrop has been completed in which a GPS receiver was integrated with a low-cost strap-down inertial navigation system and a flight computer. A Kalman filter in the latter allows in-fight alignment and calibration of the INS. In addition, feedback from the INS to the GPS receiver improves the system's ability to reacquire satellite signals after outages. The resulting system combines the accuracy of GPS with the jamming immunity and autonomy of inertial navigation. System tests were conducted in which a Boeing owned T-33 jet aircraft was flown through known test pattern to align and calibrate the INS. Earlier tests, including tests against an airborne jammer, were conducted in a modified passenger bus.