Microgravity and bone cell mechanosensitivity.

The capacity of bone tissue to alter its mass and structure in response to mechanical demands has long been recognized but the cellular mechanisms involved remained poorly understood. Bone not only develops as a structure designed specifically for mechanical tasks, but it can adapt during life toward more efficient mechanical performance. Mechanical adaptation of bone is a cellular process and needs a biological system that senses the mechanical loading. The loading information must then be communicated to the effector cells that form new bone or destroy old bone. The in vivo operating cell stress derived from bone loading is likely the flow of interstitial fluid along the surface of osteocytes and lining cells. The response of bone cells in culture to fluid flow includes prostaglandin (PG) synthesis and expression of prostaglandin G/H synthase inducible cyclooxygenase (COX-2). Cultured bone cells also rapidly produce nitric oxide (NO) in response to fluid flow as a result of activation of endothelial nitric oxide synthase (ecNOS), which enzyme also mediates the adaptive response of bone tissue to mechanical loading. Earlier studies have shown that the disruption of the actin-cytoskeleton abolishes the response to stress, suggesting that the cytoskeleton is involved in cellular mechanotransduction. Microgravity, or better near weightlessness, is associated with the loss of bone in astronauts, and has catabolic effects on mineral metabolism in bone organ cultures. This might be explained as resulting from an exceptional form of disuse under near weightlessness conditions. However, under near weightlessness conditions the assembly of cytoskeletal elements may be altered since it has been shown that the direction of the gravity vector determines microtubular pattern formation in vivo. We found earlier that the transduction of mechanical signals in bone cells also involves the cytoskeleton and is related to PGE2 production. Therefore it is possible that the mechanosensitivity of bone cells is altered under near weightlessness conditions, and that this abnormal mechanosensation contributes to disturbed bone metabolism observed in astronauts. In our current project for the International Space Station, we wish to test this hypothesis experimentally using an in vitro model. The specific aim of our research project is to test whether near weightlessness decreases the sensitivity of bone cells for mechanical stress through a decrease in early signaling molecules (NO, PGs) that are involved in the mechanical loading-induced osteogenic response. Bone cells are cultured with or without gravity prior to and during mechanical loading, using our modified in vitro oscillating fluid flow apparatus. In this "FlowSpace" project we are developing a cell culture module that is used to provide further insight in the mechanism of mechanotransduction in bone.     

High accuracy satellite drag model (HASDM)

The dominant error source in force models used to predict low-perigee satellite trajectories is atmospheric drag. Errors in operational thermospheric density models cause significant errors in predicted satellite positions, since these models do not account for dynamic changes in atmospheric drag for orbit predictions. The Air Force Space Battlelab’s High Accuracy Satellite Drag Model (HASDM) estimates and predicts (out three days) a dynamically varying global density field. HASDM includes the Dynamic Calibration Atmosphere (DCA) algorithm that solves for the phases and amplitudes of the diurnal and semidiurnal variations of thermospheric density near real-time from the observed drag effects on a set of Low Earth Orbit (LEO) calibration satellites. The density correction is expressed as a function of latitude, local solar time and altitude. In HASDM, a time series prediction filter relates the extreme ultraviolet (EUV) energy index E_10.7 and the geomagnetic storm index a_p, to the DCA density correction parameters. The E_10.7 index is generated by the SOLAR2000 model, the first full spectrum model of solar irradiance. The estimated and predicted density fields will be used operationally to significantly improve the accuracy of predicted trajectories for all low-perigee satellites.     

喉道参数对埋入式进气道气动性能的影响

以实验的方法系统地研究了喉道设计参数对埋入式进气道气动性能的影响。得出了低速下模型处于 0°攻角 ,0°侧滑及 4°侧滑时喉道位置和喉道面积比对进气道气动性能的影响。实验研究结果表明 :在适当的位置设置面积比合适的喉道可以大幅度地提高埋入式进气道的效率 ,降低进气道出口流场畸变。本文的研究为埋入式进气道喉道参数的优化设计提供了实验依据。     

Mature systems for small satellite missions

Over the past several years Satellites International has developed an integrated suite of satellite sub-systems and small satellite buses. The sub-systems include S-band communications, attitude sensing and control, power conversion and distribution, and on-board data handling. They are inherently modular and readily adaptable to different satellite configurations, a concept known as semi-standardisation. This concept has been adopted by two generic low-cost buses: MicroSIL for satellites in the mass range 40–80kg; and MiniSIL for satellites in the range 100–500kg. Their architecture is based on the semi-standard sub-systems, but easily modified to utilise sub-systems from other manufacturers. They can support all stabilisation methods including spinning, 3-axis control and gravity gradient and are adaptable to a wide variety of missions including Earth resources, scientific, communications and technology demonstration. The Company also manufactures a range of low cost ground support equipment and complete ground stations to complement the space-borne systems.     

AUTOMATIC FINITE ELEMENT MODELING OF A WING

研究了建立机翼有限元模型的自动化。用行列法标识结构的部件（肋、梁、蒙皮、立柱）,并用简单明了的表格界面来输入所有部件的几何、网格密度、材料、载荷、边界条件等参数。设计并用ＰＣＬ（ＰＡＴＲＡＮｃｏｍｍａｎｄｌａｎｇｕａｇｅｕｎｄｅｒＰＡＴＲＡＮ６．０）编制了相应的自动化建立整个机翼有限元模型的用户化程序模块。作为算例建立了ＶＦＷ６１４机翼的有限元模型并用ＮＡＳＴＲＡＮ６８进行了计算。结果表明,本方法有效和高效。     

并行子空间设计算法在电动无人机一体化设计中的应用

应用并行子空间设计算法对低雷诺数电动无人机进行了初步设计.电动无人机涉及多门学科,包括气动、重量、推进系统、性能和操稳.首先开发了电动无人机多学科系统分析软件.并行子空间设计算法利用基于人工神经网络的响应面技术作为系统分析的近似模型.电动无人机初步设计中的设计变量共有29个,其中连续设计变量25个,离散设计变量4个.研究表明,并行子空间设计算法能以较少的系统分析次数在可行域内寻找出一个较好的设计点,并在设计过程中具有适应设计要求(约束)可变性的要求,它为飞行器一体化设计提供了一条途径.     

Six-month space greenhouse experiments--a step to creation of future biological life support systems

SVET Space Greenhouse (SG)--the first automated facility for growing of higher plants in microgravity was designed in the eighty years to be used for the future BLSS. The first successful experiment with vegetables was carried out in 1990 on the MIR Space Station (SS). The experiments in SVET SG were resumed in 1995, when an American Gas Exchange Measurement System (GEMS) was added. A three-month wheat experiment was carried out as part of MIR-SHUTTLE'95 program. SVET-2 SG Bulgarian equipment of a new generation with optimised characteristics was developed (financed by NASA). The new SVET-GEMS equipment was launched on board the MIR SS and a successful six-month experiments for growing up of two crops of wheat were conducted in 1996 - 97 as part of MIR-NASA-3 program. The first of these "Greenhouse" experiments (123 days) with the goal to grow wheat through a complete life cycle is described. Nearly 300 heads developed but no seeds were produced. A second crop of wheat was planted and after 42 days the plants were frozen for biochemical investigations. The main environmental parameters during the six-month experiments in SVET (substrate moisture and lighting period) are given. The results and the contribution to BLSS are discussed.     

The response of the Hermean magnetosphere to the interplanetary magnetic field

The interaction between the solar wind and Mercury is anticipated to be unique because of Mercury’s relatively weak intrinsic magnetic field and tenuous neutral exosphere. In this paper the role of the IMF in determining the structure of the Hermean magnetosphere is studied using a new self-consistent three-dimensional quasi-neutral hybrid model. A comparison between a pure northward and southward IMF shows that the general morphology of the magnetic field, the position and shape of the bow shock and the magnetopause as well as the density and velocity of the solar wind in the magnetosheath and in the magnetosphere are quite similar in these two IMF situations. A Parker spiral IMF case, instead, produces a magnetosphere with a substantial north–south asymmetric plasma and magnetic field configuration. In general, this study illustrates quantitatively the role of IMF when the solar wind interacts with a weakly magnetised planetary body.     

X-ray spectroscopy and variability of AGN detected in the 2 Ms Chandra Deep Field-North Survey

We investigate the nature of the faint X-ray source population through X-ray spectroscopy and variability analyses of 136 active galactic nuclei (AGN) detected in the 2 Ms Chandra Deep Field-North Survey with >200 background-subtracted 0.5–8.0 keV counts [F_{0.5–8.0 keV} = (1.4−200) × 10⁻¹⁵ erg cm⁻² s⁻¹]. Our preliminary spectral analyses yield median spectral parameters of Γ = 1.61 and intrinsic N_H = 6.2 × 10²¹ cm⁻² (z = 1 assumed when no redshift available) when the AGN spectra are fitted with a simple absorbed power-law model. However, considerable spectral complexity is apparent (e.g., reflection, partial covering) and must be taken into account to model the data accurately. Moreover, the choice of spectral model (i.e., free vs. fixed photon index) has a pronounced effect on the derived JVH distribution and, to a lesser extent, the X-ray luminosity distribution. We also find that among the 136 AGN, 10 (≈7%) show significant Fe K emission-line features with equivalent widths in the range 0.1–1.3 keV. Two of these emission-line AGN could potentially be Compton thick (i.e., Γ < 1.0 and large Fe K equivalent width). Finally, we find that 81 (≈60%) of the 136 AGN show signs of variability, and that this fraction increases significantly (≈80–90%) when better photon statistics are available.