Cognitive deficits induced by 56Fe radiation exposure.

Exposing rats to particles of high energy and charge (e.g., 56Fe) disrupts neuronal systems and the behaviors mediated by them; these adverse behavioral and neuronal effects are similar to those seen in aged animals. Because cognition declines with age, and our previous study showed that radiation disrupted Morris water maze spatial learning and memory performance, the present study used an 8-arm radial maze (RAM) to further test the cognitive behavioral consequences of radiation exposure. Control rats or rats exposed to whole-body irradiation with 1.0 Gy of 1 GeV/n high-energy 56Fe particles (delivered at the alternating gradient synchrotron at Brookhaven National Laboratory) were tested nine months following exposure. Radiation adversely affected RAM performance, and the changes seen parallel those of aging. Irradiated animals entered baited arms during the first 4 choices significantly less than did controls, produced their first error sooner, and also tended to make more errors as measured by re-entries into non-baited arms. These results show that irradiation with high-energy particles produces age-like decrements in cognitive behavior that may impair the ability of astronauts to perform critical tasks during long-term space travel beyond the magnetosphere.     

Mutation induction in human lymphoid cells by energetic heavy ions.

One of the concerns for extended space flight outside the magnetosphere is exposure to galactic cosmic radiation. In the series of studies presented herein, the mutagenic effectiveness of high energy heavy ions is examined using human B-lymphoblastoid cells across an LET range from 32keV/micrometer to 190 keV/micrometer. Mutations were scored for an autosomal locus, thymidine kinase (tk), and for an X-linked locus, hypoxanthine phosphoribosyltransferase (hprt). For each of the radiations studied, the autosomal locus is more sensitive to mutation induction than is the X-linked locus. When mutational yields are expressed in terms of particle fluence, the two loci respond quite differently across the range of LET. The action cross section for mutation induction peaks at 61 keV/micrometer for the tk locus and then declines for particles of higher LET, including Fe ions. For the hprt locus, the action cross section for mutation is maximal at 95 keV/micrometer but is relatively constant across the range from 61 keV/micrometer to 190 keV/micrometer. The yields of hprt-deficient mutants obtained after HZE exposure to TK6 lymphoblasts may be compared directly with published data on the induction of hprt-deficient mutants in human neonatal fibroblasts exposed to similar ions. The action cross section for induction of hprt-deficient mutants by energetic Fe ions is more than 10-fold lower for lymphoblastoid cells than for fibroblasts.     

A program to measure new energetic particle nuclear interaction cross sections.

The Transport Collaboration, consisting of researchers from institutions in France, Germany, Italy and the USA, has established a program to make new measurements of nuclear interaction cross sections for heavy projectiles (Z > or = 2) in targets of liquid H2, He and heavier materials. Such cross sections directly affect calculations of galactic and solar cosmic ray transport through matter and are needed for accurate radiation hazard assessment. To date, the collaboration has obtained data using the LBL Bevalac HISS facility with 20 projectiles from 4He to 58Ni in the energy range 393-910 MeV/nucleon. Preliminary results from the analysis of these data are presented here and compared to other measurements and to cross section prediction formulae.     

Suboptimal joint probabilistic data association

A significant problem in multiple target tracking is the hit-to-track data association. A hit is a received signal from a target or background clutter which provides positional information. If an incorrect hit is associated with a track, that track could diverge and terminate. Prior methods for this data association problem include various optimal and suboptimal two-dimensional assignment algorithms which make hit-to-track associations. Another method is to assign a weight for the reasonable hits and use a weighted centroid of those hits to update the track. The method of weighting the hits is known as joint probabilistic data association (JPDA). The authors review the JPDA approach and a simple ad hoc approximation and then introduce a new suboptimal JPDA algorithm. Examples which compare an optimal two-dimensional assignment algorithm with the ad hoc and the new suboptimal JPDA formulation are given     

Guiding technology development and transition into productsresponsive to end-user needs

It is argued that a systems engineering process that develops an understanding of end-user needs and economically develops a product system which includes the right technology advances to satisfy these needs is the best way to ensure success in the market of end-user needs. This customer pulled approach to new and improved products also pulls the necessary technology developments with it and integrates their timing and resource requirements into those of the end product planning. With appropriate concurrent, cross-functional teams working both the planning and the execution, this approach benefits from the wisdom and leadership of the end-user focused team to deliver the desired program results on schedule. This frees top leadership to focus on longer range visions for the product line and technologies     

Image texture synthesis-by-analysis using moving-average models

A synthesis-by-analysis model for texture replication or simulation is presented. This model can closely replicate a given textured image or produce another image that although distinct from the original, has the same general visual characteristics and the same first and second-order gray-level statistics as the original image. The texture synthesis algorithm, proposed contains three distinct components: a moving-average (MA) filter, a filter excitation function, and a gray-level histogram. The analysis portion of the texture synthesis algorithm derives the three from a given image. The synthesis portion convolves the MA filter kernel with the excitation function, adds noise, and modifies the histogram of the result. The advantages of this texture model over others include conceptually and computationally simple and robust parameter estimation, inherent stability, parsimony in the number of parameters, and synthesis through convolution. The authors describe a procedure for deriving the correct MA kernel using a signal enhancement algorithm, demonstrate the effectiveness of the model by using it to mimic several diverse textured images, discuss its applicability to the problem of infrared background simulation, and include detailed algorithms for the implementation of the model     

A two-dimensional position-sensitive spectroscopic proportional counter for balloon-borne hard X-ray astronomy

A new design of position sensitive spectroscopic proportional counter is described, for use in a balloon borne hard x-ray telescope. Initial position and spectral resolution data from a one-dimensional laboratory prototype are reported. With this device, the final telescope will have an angular resolution of better than 10 minutes of arc.     

Design study for a three-meter balloon-borne telescope for far infrared and submillimeter astronomy

A NASA supported design study is being carried out for a three-meter balloon-borne far infrared and submillimeter telescope. The goal of this project is to provide a facility for frequent flights for photometry, spectroscopy, and imaging in the spectral region 30 micrometers to 1 millimeter. It is intended to provide a scientific and technical step on the way to a large submillimeter telescope in space in the future. The study is concentrating on areas where technical advances are required: materials and fabrication techniques for lightweight primary mirrors, telescope and gondola structure, and pointing and stabilization. We are carrying out a design optimization and environmental test program of state-of-the-art carbon fiber reinforced plastic sandwich panels in collaboration with Dornier Systems. Similar efforts are being pursued for very lightweight molded glass mirrors. Innovative approaches to the telescope support and stabilization are being explored for achieving the required 1 arcsecond pointing stability.     

Preliminary results of Cytos 2 experiment.

Cytos 2 experiment, carried out during the French-Soviet manned flight (July 1982), has studied the antibiotics sensitivity of bacteria cultivated in vitro during the orbital flight. The results show an increase of the antibiotics resistance and a larger thickness of the cellular envelope for the inflight cells. The increase of antibiotics resistance can be related to a stimulating effect of space on the cell growth rate or to changes of the cellular envelope structure.     

Investigation of natural and artificial stimulation of the ionospheric Alfvén resonator at high latitude

A brief review is provided of recent progress in understanding the ionospheric Alfvén resonator (IAR) at high latitude. Firstly, naturally occurring resonances of the IAR as detected by pulsation magnetometers in the auroral zone at Sodankylä and in the polar cap at Barentsburg are considered. The characteristics of the IAR in the two regions are broadly similar, although the effects of solar illumination are less clear at the higher latitudes. Secondly we review recent attempts to stimulate the IAR through high-power radio frequency experiments both in the auroral zone at Tromsø with the European Incoherent SCATter (EISCAT) heater, and within the polar cap at Longyearbyen with the Space Plasma Exploration by Active Radar (SPEAR) facility. In the auroral zone at, Tromsø the stimulated IAR has been observed by ground-based magnetometers, and through electron acceleration observed on the FAST spacecraft. At SPEAR in the polar cap, the stimulated IAR has been investigated, with ground magnetometers, with the first results indicative of a positive detection.