Behavioral toxicity of selected radioprotectors.

Effective radioprotection with minimal behavioral disruption is essential for the selection of protective agents to be used in manned spaceflight. This overview summarizes the studies on the behavioral toxicity of selected radioprotectors classified as phosphorothioates (WR-2721, WR-3689), bioactive lipids (16, 16 dimethylprostaglandin E2(DiPGE2), platelet activating factor (PAF), leukotriene C4), and immunomodulators (glucan, synthetic trehalose dicorynomycolate, and interleukin-1). Behavioral toxicity was examined in laboratory mice using a locomotor activity test. For all compounds tested, there was a dose-dependent decrease in locomotor behavior that paralleled the dose-dependent increase in radioprotection. While combinations of radioprotective compounds (DiPGE2 plus WR-2721) increased radioprotection, they also decreased locomotor activity. The central nervous system stimulant, caffeine, was able to mitigate the locomotor decrement produced by WR-3689 or PAF.     

Optimal control of the Shuttle-Tethered-Subsatellite system

Alternate control laws based on an application of the linear regulator problem are developed for possible use in the operation of the Shuttle-Tethered-Subsatellite system. Control is assumed to be provided only by modulating the tension level in the tether as a function of the difference between actual and commanded tether line length, length rate, in (orbital) plane swing angle and swing angle rate. Necessary and sufficient conditions for stability of the (linear) system motion in the vicinity of its nominal local vertical orientation are developed. By proper selection of the state and control penalty matrices it is possible to obtain faster responses with no increase in maximum power levels for use in station keeping when compared with alternate control strategies. The weighting matrices are adjusted in a piecewise adaptive manner to provide control law gains in order to achieve a smooth deployment history. Successful retrievel is dependent mainly on the initial conditions and the rate at which the commanded length is reduced.     

Mechanical properties of ANTRIX balloon film and fabrication of single cap large volume balloons

The zero pressure plastic balloons used for high altitude studies are generally made from polyethylene material. Tensile properties of the thin film polymer are the key parameters for material selection due to extremely low temperature of −90 °C encountered by the balloons in the tropopause region during the ascent at equatorial latitudes. The physical and structural properties of the material determine the uniformity of the stress distribution over the entire shell. Load stresses from the suspended load propagate via load tapes heat sealed along with the gore seals as per the balloon design. A balance between this heat seal strength and the film strength is a desirable property of the basic resin in terms of the bubble strength, gauge uniformity, and long-term storage properties. In addition, the design of the top shell of the balloon and its stress distribution play an important role since only a fraction of the balloon is deployed during the filling operation and the ascent. In this paper we describe the mechanical properties of the ‘ANTRIX’ film developed by us and the optimized design of single cap balloons, which have been successfully used in our experiments over the past 5 years.