Expression of estrogen receptor α in human breast cancer cells regulates mitochondrial oxidative stress under simulated microgravity

This study investigated intracellular oxidative stress and its underlying mechanisms in a rotary cell culture system used to achieve a simulated microgravity (SMG) environment. Experiments were conducted with human breast cancer cell lines MCF-7 (an estrogen receptor (ER) α positive cell line) and MDA-MB-231 (an ERα negative cell line) encapsulated in alginate/collagen carriers. After 48 h, SMG led to oxidative stress and DNA damage in the MDA-MB-231 cells but a significant increase in mitochondrial activity and minimal DNA damage in the MCF-7 cells. The activity of superoxide dismutase (SOD) significantly increased in the MCF-7 cells and decreased in MDA-MB-231 cells in the SMG environment compared with a standard gravity control. Moreover, SMG promoted expression of ERα and protein kinase C (PKC) epsilon in MCF-7 cells treated with PKC inhibitor Gö6983. Overall, exposure to SMG increased mitochondrial activity in ERα positive cells but induced cellular oxidative damage in ERα negative cells. Thus, ERα may play an important role in protecting cells from oxidative stress damage under simulated microgravity.     

涡流图像的革新

通过加强涡流仪器的观察平台,通过简化判断程序,通过色码选择信息和发展新技术,使得较多的用户友好界面途径信息体现出来,涡流检测才能实现它的全部潜能.     

Virtual flight test techniques to predict a blended-wing-body aircraft in-flight departure characteristics

As one of the promising configurations of the next generation of commercial aircraft,research on departure characteristics of the Blended-Wing-Body(BWB) is of great signification to safe flight limits. A three-degree-of-freedom(3-DOF) virtual flight test in a wind tunnel has been implemented for a candidate configuration to predict the departure characteristics. The support mechanism, the test model and the control law of the virtual flight test are introduced. In order to show the relationship ...     

Station-keeping control for a stratospheric airship platform via fuzzy adaptive backstepping approach

This paper presents a novel approach for station-keeping control of a stratospheric airship platform in the presence of parametric uncertainty and external disturbance. First, conceptual design of the stratospheric airship platform is introduced, including the target mission, configuration, energy sources, propeller and payload. Second, the dynamics model of the airship platform is presented, and the mathematical model of its horizontal motion is derived. Third, a fuzzy adaptive backstepping control approach is proposed to develop the station-keeping control system for the simplified horizontal motion. The backstepping controller is designed assuming that the airship model is accurately known, and a fuzzy adaptive algorithm is used to approximate the uncertainty of the airship model. The stability of the closed-loop control system is proven via the Lyapunov theorem. Finally, simulation results illustrate the effectiveness and robustness of the proposed control approach.     

Investigations of an integrated angular velocity measurement and attitude control system for spacecraft using magnetically suspended double-gimbal CMGs

This paper presents an integrated angular velocity measurement and attitude control system of spacecraft using magnetically suspended double-gimbal control moment gyros (MSDGCMGs). The high speed rotor of MSDGCMG is alleviated by a five-degree-of-freedom permanent magnet biased AMB control system. With this special rotor supported manner, the MSDGCMG has the function of attitude rate sensing as well as attitude control. This characteristic provides a new approach to a compact light-weight spacecraft design, which can combine these two functions into a single device. This paper discusses the principles and implementations of AMB-based angular velocity measurement. Spacecraft dynamics with DGMSCMG actuators, including the dynamics of magnetically suspended high-speed rotor, the dynamics of inner gimbal and outer gimbal, as well as the determination method of spacecraft angular velocity are modeled, respectively. The effectiveness of the proposed integrated system is also validated numerically and experimentally.     

一种敏感电路式露点测量方法

针对大气湿度测量问题,提出一种基于敏感电路的露点测量方法.把考比兹电路中的石英晶体作为湿敏元件,用半导体制冷器对其进行制冷直到有结露产生时使得石英晶体处于液相环境中,整个考比兹电路将停止振动,利用考比兹电路这一敏感特性对露点进行识别,可以得到相应的露点温度.通过理论数据与实验数据对比分析,露点温度的最大误差为1.59℃,此方法可以从定性的角度作为一种湿度快速识别方法,并具有测量方法简单、灵敏度高、可靠性好和成本低等优点.     

巡航导弹群突防舰载反导系统快速分析模型

针对巡航导弹初始设计阶段需要频繁进行人机对话的特点,引入拦截弹拦截性能修正因子的概念,综合运用导弹分析方法中的估计方法与检验方法,以突防效率为评价指标采用新思路建立了巡航导弹群突防舰载反导系统快速分析模型,为初始设计阶段提高巡航导弹作战性能提供快速、可靠的数学工具.基于所建立的快速分析模型,对影响巡航导弹突防典型舰载反导系统的主要因素进行灵敏度分析,分析结果可为巡航导弹设计指明方向.     

碰撞触发式非合作目标对接捕获机构设计

针对非合作目标航天器对接与捕获,设计了一种新型的对接机构.根据非合作目标不配合对接过程,且一直处于运动状态的特点,进行了概念设计.采用了自主的、依靠碰撞触发瞬时触发的对接模式.基于对机构动力学建模分析,用Adams解算器完成了对接过程的数学仿真,验证了机构能有效进行对非合作目标的自主捕获,确定了对接机构的正常工作相对速度范围.     

卫星运动对压缩编码孔径光谱成像的影响

用于遥感光谱成像的光谱成像仪普遍存在信息获取慢、光子收集效率低、信噪比低或焦平面阵列大等问题,另外数据立方体庞大的数据量给数据传输造成了极大压力。为了从根本上解决这些问题,文章提出将压缩编码孔径应用于遥感光谱成像中,即压缩编码孔径遥感光谱成像。文章对卫星平台的俯仰、侧滚和偏航运动进行建模,然后利用此模型对成像过程进行仿真和重建,提高了成像品质。由于运动模型以及压缩编码孔径成像技术的引入,使得遥感光谱图像的压缩在成像过程中完成,从而大大提高了传统焦平面阵列的利用率,减小了数据传输的压力,减小了成像光谱仪的体积、质量与成本。     

生物膜法在微污染水源水预处理中的应用

微污染水源水的传统净水工艺对有机物的去除率较低，若采用生物膜法去除微污染水源水中的溶解态有机物，既比常规净水工艺效果好又经济有效，具有一定的优势和发展前景。