Thyrotropin receptor and membrane interactions in FRTL-5 thyroid cell strain in microgravity

The aim of this work was to analyze the possible alteration of thyrotropin (TSH) receptors in microgravity, which could explain the absence of thyroid cell proliferation in the space environment. Several forms of the TSH receptor are localized on the plasma membrane associated with caveolae and lipid rafts. The TSH regulates the fluidity of the cell membrane and the presence of its receptors in microdomains that are rich in sphingomyelin and cholesterol. TSH also stimulates cyclic adenosine monophosphate (cAMP) accumulation and cell proliferation. Reported here are the results of an experiment in which the FRTL-5 thyroid cell line was exposed to microgravity during the Texus-44 mission (launched February 7, 2008, from Kiruna, Sweden). When the parabolic flight brought the sounding rocket to an altitude of 264?km, the culture media were injected with or without TSH in the different samples, and weightlessness prevailed on board for 6 minutes and 19 seconds. Control experiments were performed, in parallel, in an onboard 1g centrifuge and on the ground in Kiruna laboratory. Cell morphology and function were analyzed. Results show that in microgravity conditions the cells do not respond to TSH treatment and present an irregular shape with condensed chromatin, a modification of the cell membrane with shedding of the TSH receptor in the culture medium, and an increase of sphingomyelin-synthase and Bax proteins. It is possible that real microgravity induces a rearrangement of specific sections of the cell membrane, which act as platforms for molecular receptors, thus influencing thyroid cell function in astronauts during space missions.     

Microperturbations on the <Emphasis Type=Italic>International Space Station</Emphasis> during physical exercises of the crew

The results of a preliminary analysis of microperturbations on the International Space Station during physical exercises of the crew are presented. The goal of this paper is to identify the parameters of perturbations when physical exercises are performed. The results of measurements by sensors of microaccelerations of both Russian and American segments during physical exercises in the service module of the Russian segment are analyzed.     

Statistical study of interplanetary condition effect on geomagnetic storms: 2. Variations of parameters

We investigate the behavior of mean values of the solar wind’s and interplanetary magnetic field’s (IMF) parameters and their absolute and relative variations during the magnetic storms generated by various types of the solar wind. In this paper, which is a continuation of paper [1], we, on the basis of the OMNI data archive for the period of 1976–2000, have analyzed 798 geomagnetic storms with D _st ≤ −50 nT and their interplanetary sources: corotating interaction regions CIR, compression regions Sheath before the interplanetary CMEs; magnetic clouds MC; “Pistons” Ejecta, and an uncertain type of a source. For the analysis the double superposed epoch analysis method was used, in which the instants of the magnetic storm onset and the minimum of the D _st index were taken as reference times. It is shown that the set of interplanetary sources of magnetic storms can be sub-divided into two basic groups according to their slowly and fast varying characteristics: (1) ICME (MC and Ejecta) and (2) CIR and Sheath. The mean values, the absolute and relative variations in MC and Ejecta for all parameters appeared to be either mean or lower than the mean value (the mean values of the electric field E _y and of the B _z component of IMF are higher in absolute value), while in CIR and Sheath they are higher than the mean value. High values of the relative density variation sN/〈N〉 are observed in MC. At the same time, the high values for relative variations of the velocity, B _z component, and IMF magnitude are observed in Sheath and CIR. No noticeable distinctions in the relationships between considered parameters for moderate and strong magnetic storms were observed.     

Optical properties of the undisturbed mesosphere from wide-angle twilight sky polarimetry

The paper describes the first results of all-sky polarization measurements of the twilight background started in central Russia in the very beginning of summer 2011. Time-frequency data of the sky intensity and polarization over a wide range of sky point zenith distances are used to separate single and multiple scattering and construct the altitude dependence of the scattering coefficient and polarization in the mesosphere (altitudes from 60 to 90 km) at different angles. The undisturbed structure of the mesosphere without noticeable aerosol stratification on observation days makes it possible to estimate the temperature of the atmosphere at these altitudes.     

On the arc length of observations of a small solar system body sufficient to classify it as hazardous

This paper analyzes the accuracy of orbit determination calculated by observations of short arcs. In this case, we imposed the condition that the arc length and/or the distribution of arc observations should provide a confident classification of the orbit of a small celestial body allowing one to distinguish a potentially hazardous body, also including a threat of collision.     

Evaluating the economic impact of design alternatives on domestic communication satellite ventures

What are the economic consequences of establishing a domestic communication satellite venture? Has the best design alternative been selected? Should investments be made to develop new technology? How much should be invested? These are but some of the questions facing those concerned with providing domestic communication satellite services. Because of the demand, performance and cost uncertainties and the unpredictability of the need for and timing of large capital expenditures (due to less than perfect reliability of transportation systems and satellites) providing answers to these and other related questions is a complex process.This paper describes a methodology for providing answers to the above questions. The methodology, by explicitly considering demand, performance and cost uncertainties and satellite and transportation system reliability, develops probabilistic pro forma financial analyses of domestic communication satellite system ventures. In so doing, the risk dimension is quantified and alternative courses of action can be evaluated and compared taking into account expected values, risk and risk aversion preferences. It is also important to quantify and consider the risk dimension since many R &; D projects are specifically aimed at risk reduction.     

Missile Electronic System Hardness Assurance Program

A hardness assurance program suitable for a retaliatory or deterrent missile system is discussed. The program consists of three phases: the establishment of suitable controls and screens to ensure piece part hardness, a supplier data monitoring program to measure hardness related parameters in a timely fashion to obtain advanced warning of potential problems, and a hardness assurance verification testing (HAVT) program to periodically measure the radiation response of parts, circuits, subsystems, and systems on a sample basis to ensure proper functioning in simulated radiation environments. All of the data relevant to hardness assurance is stored in computer memory and routinely interrogated with programs which compare current results with the engineering baseline data and other data from preceding lots. Other computer programs enable statistical estimation of system response to the radiation environment with confidence based on the expanding data base provided by the HAVT program.     

Electron flux variations at altitudes of 600–800 km in the second half of 2014. preliminary results of an experiment using RELEC equipment onboard the satellite <Emphasis Type="Italic">VERNOV</Emphasis>

The results of measurements of fluxes and spectra carried out using the RELEC (relativistic electrons) equipment onboard the VERNOV satellite in the second half of 2014 are presented. The VERNOV satellite was launched on July 8, 2014 in a sun-synchronous orbit with an altitude from 640 to 830 km and an inclination of 98.4°. Scientific information from the satellite was first received on July 20, 2014. The comparative analysis of electron fluxes using data from RELEC and using experimental data on the electron detection by satellites Elektro-L (positioned at a geostationary orbit) and Meteor-M no. 2 (positioned at a circular polar orbit at an altitude of about 800 km as the VERNOV satellite) will make it possible to study the spatial distribution pattern of energetic electrons in near-Earth space in more detail.     

Satellite dynamics under the influence of gravitational and aerodynamic torques. A study of stability of equilibrium positions

The dynamics of the rotational motion of a satellite, moving in the central Newtonian force field under the influence of gravitational and aerodynamic torques, is investigated. The paper proposes a method for determining all equilibrium positions (equilibrium orientations) of a satellite in the orbital coordinate system for specified values of aerodynamic torque and the major central moments of inertia; the sufficient conditions for their existence are obtained. For each equilibrium orientation the sufficient stability conditions are obtained using the generalized energy integral as the Lyapunov function. The detailed numerical analysis of the regions where the stability conditions of the equilibrium positions are satisfied is carried out depending on four dimensionless parameters of the problem. It is shown that, in the general case, the number of satellite’s equilibrium positions, for which the sufficient stability conditions are satisfied, varies from 4 to 2 with an increase in the value of the aerodynamic torque magnitude.     

Chemistry of the outer solar system

Data on the composition of the satellites of the outer planets and the composition and structure of planetary atmospheres are briefly reviewed in light of simple models for the origin of the solar system and the planets. Some crucial tests of present theories are suggested.Contribution No. 52 of the MIT Planetary Astronomy Laboratory.This is one of the publications by the Science Advisory Group.