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251.
F J Burns Y Jin S J Garte S Hosselet 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1994,14(10):507-519
In the multistage theory of carcinogenesis, cells progress to cancer through a series of discrete, irreversible, heritable genetic alterations or mutations. However data on radiation-induced cancer incidence in rat skin suggests that some part of an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to the following radiations: 1. an electron beam (LET=0.34 keV/um, 2. a neon ion beam (LET=25 keV/um and 3. an argon ion beam (LET=125 keV/um. The latter 2 beams were generated by the Bevalac at the Lawrence Berkeley Laboratory, Berkeley, CA. About 6.0 cm2 of skin was irradiated per rat. The rats were observed every 6 weeks for at least 78 weeks and tumors were scored at first occurrence. Several histological types of cancer, including squamous and basal cell carcinomas, were induced. The cancer yield versus radiation dose was fitted by the quadratic equation (Y(D)=CLD+BD2), and the parameters C and B were estimated for each type of radiation. Analysis of the DNA from the electron-induced carcinomas indicated that K-ras and/or c-myc oncogenes were activated in all tumors tested, although only a small proportion of neon-induced tumors showed similar activation. In situ hybridization indicated that the cancers contain subpopulations of cells with differing amounts of c-myc and H-ras amplification. The results are consistent with the idea that ionizing radiation produces carcinogenically relevant lesions via 2 repairable events at low LET and via a non-repairable, linked event pathway at high LET; either pathway may advance the cell by 1 stage in the multistage model. The model, if validated, permits the direct calculation of cancer risk in rat skin in a way that can be subjected to experimental testing. 相似文献
252.
C S Brown W C Piastuch W M Knott 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1994,14(8):107-110
We have demonstrated that etiolated soybean seedlings grown under the altered gravity conditions of clinorotation (1 rpm) and centrifugation (5xg) exhibit changes in starch metabolism. Cotyledon starch concentration was lower (-28%) in clinorotated plants and higher (+24%) in centrifuged plants than in vertical control plants. The activity of ADP-glucose pyrophosphorylase in the cotyledons was affected in a similar way, i.e. lower (-37%) in the clinorotated plants and higher (+22%) in the centrifuged plants. Other starch metabolic enzyme activities, starch synthase, starch phosphorylase and total hydrolase were not affected by the altered gravity treatments. We conclude that the observed changes in starch concentrations were primarily due to gravity-mediated differences in ADP-glucose pyrophosphorylase activity. 相似文献
253.
Morgan C.J. Moyer L.R. Wilson R.S. 《Aerospace and Electronic Systems Magazine, IEEE》1996,11(3):41-43
A technique is presented for determining the ideal detection threshold when Gaussian noise and Weibull distributed clutter returns are present on a radar receiver and neither is dominant. Quantitative data is presented for several clutter types and false alarm probabilities 相似文献
254.
J C Guillemin S El Chaouch A Bouayad T Janati 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2001,27(2):245-253
The photolysis of mixtures of gases containing NH3 or PH3 presents important differences mainly due to the strength of the X-H bond. On some examples, these differences are evidenced and the consequences for mixtures of gases containing these two compounds are shown: the photolysis of ammonia and ethylene mainly gives ethyl-, butyl- and hexylamine whereas the photolysis of phosphine and ethylene leads to ethyl- and vinylphosphine. When gaseous mixtures of NH3, PH3 and ethylene are photolyzed together, the presence of phosphine dramatically decreases the formation of nitrogen derivatives. The relevance of such lab studies to the atmospheres of Jupiter and Saturn is discussed. 相似文献
255.
K Kobayashi H Masuda K I Ushio A Ohashi H Yamanashi T Kaneko J I Takahashi T Hosokawa H Hashimoto T Saito 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2001,27(2):207-215
Various types of organic compounds have been detected in Jupiter, Titan, and cometary coma. It is probable that organic compounds were formed in primitive Earth and Mars atmospheres. Cosmic rays and solar UV are believed to be two major energy sources for organic formation in space. We examined energetics of organic formation in simulated planetary atmospheres. Gas mixtures including a C-source (carbon monoxide or methane) and a N-source (nitrogen or ammonia) was irradiated with the followings: High energy protons or electrons from accelerators, gamma-rays from 60Co, UV light from a deuterium lamp, and soft X-rays or UV light from an electron synchrotron. Amino acids were detected in the products of particles, gamma-rays and soft X-rays irradiation from each gas mixture examined. UV light gave, however, no amino acid precursors in the gas mixture of carbon monoxide, nitrogen and nitrogen. It gave only a trace of them in the gas mixture of carbon monoxide, ammonia and water or that of methane, nitrogen and water. Yield of amino acid precursors by photons greatly depended on their wavelength. These results suggest that nitrogen-containing organic compounds like amino acid precursors were formed chiefly with high energy particles, not UV photons, in Titan or primitive Earth/Mars atmospheres where ammonia is not available as a predominant N-source. 相似文献
256.
A.I. Podgorny I.M. Podgorny 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1997,19(12):1929-1932
The patterns of reconnection in the Earth magnetotail and in the solar corona above the active region are presented. The electric field and field-aligned currents (FAC) generation in the current sheet are discussed. 相似文献
257.
S I Ramirez R Navarro-Gonzalez P Coll F Raulin 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2001,27(2):261-270
A quantitative comparison of the products arising from the irradiation of a Titan's simulated atmosphere is presented. The energy sources used represent some of the main events that occur in the satellite's atmosphere. All of the compounds identified are classified in the hydrocarbon and nitrile chemical families. Almost all of the detected compounds in Titan's atmosphere are produced by one or more energy sources. The compounds with the highest energy yields include the C2 hydrocarbons, methanonitrile and ethanonitrile. The possibility of using some of the produced organics as tracer compounds during the Huygens descend to identify the leading energy form in the different atmospheric levels remains open. 相似文献
258.
V. Formisano V.I. Moroz H. Hirsch P. Orleanski G. Michel J. Lopez-Moreno E. Amata G. Bellucci G. Piccioni G. Chionchio A. Carusi A. Coradini P. Cerroni M.T. Capria F. Capaccioni A. Adriani M. Vitterbini F. Angrilli G. Bianchini B. Saggin S. Fonti E. Bussoletti D. Mancini L. Colangeli A. Grigoriev B. Moshkin V. Gnedykh I.A. Matsygorin D. Patsaev Yu.V. Nikolsky D.V. Titov L.V. Zasova I. Khatuntsev A. Kiselev G. Arnold H. Driesher M.I. Blecka R. Rodrigo J. Rodriguez-Gomez 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1996,17(12):61-64
Thin films containing a mixture of aliphatic (glycine) and aromatic (tryptophan or tyrosine) amino acids were exposed to a vacuum ultraviolet radiation (VUV) with wavelenghts 100–200 nm. Dipeptides (glycyl-tryptophan and glycyl-tyrosine) were synthesized in these conditions. We compared the actions of VUV and γ-radiation. Polymerization is an essential step in prebiological evolution and we have shown that this stage probably occured over an early Solar system history. 相似文献
259.
J L Shinn J E Nealy L W Townsend J W Wilson J S Wood 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1994,14(10):863-871
Using the Langley Research Center galactic cosmic ray (GCR) transport computer code (HZETRN) and the computerized anatomical man (CAM) model, crew radiation levels inside manned spacecraft on interplanetary missions are estimated. These radiation-level estimates include particle fluxes, LET (linear energy transfer) spectra, absorbed dose, and dose equivalent within various organs of interest in GCR protection studies. Changes in these radiation levels resulting from the use of various different types of shield materials are presented. 相似文献
260.
A A Tikhomirov S A Ushakova 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2001,27(9):1535-1539
Our experiments examined enhancing tolerance of the photosynthesizing component to possible deviations in thermal or illumination conditions inside a bioregenerative life support system (BLSS). In the event of one parameter getting beyond its optimum, the values of other parameters may ensure minimal damage to the plant component during the period of environmental stress. With wheat plants (one of key elements of the plant component) as an example the work considers whether it is possible to enhance thermal tolerance by varying light intensity. Increase of air temperature to 35 degrees C or 45 degrees C with light intensity of 60 W/m2 PAR has been shown to substantially inhibit the photosynthesis processes; at 150 W/m2 PAR photosynthesis decreases from 50% to 100%, respectively; when light intensity is increased to 240 W/m2 PAR photosynthesis increased more than 70% at 35 degrees C and decreased at 45 degrees C by only 20%. Thus, light intensity can be increased to avoid or decrease the inhibiting effect of high temperatures. On the other hand, tolerance of wheat plants to prolonged absence of light can be substantially enhanced by decreasing during this period air temperature to temperatures close to 0 degrees C. 相似文献