Early effects of low dose C ion or X-ray irradiation on human peripheral blood lymphocytes

The aim of this study was to estimate the acute effects of low dose ¹²C⁶⁺ ions or X-ray radiation on human immune function. The human peripheral blood lymphocytes (HPBL) of seven healthy donors were exposed to 0.05 Gy ¹²C⁶⁺ ions or X-ray radiation and cell responses were measured at 24 h after exposure. The cytotoxic activities of HPBL were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT); the percentages of T and NK cells subsets were detected by flow cytometry; mRNA expression of interleukin (IL)-2, tumor necrosis factor (TNF)-α and interferon (IFN)-γ were examined by real time quantitative RT-PCR (qRT-PCR); and these cytokines protein levels in supernatant of cultured cells were assayed by enzyme-linked immunosorbent assays (ELISA). The results showed that the cytotoxic activity of HPBL, mRNA expression of IL-2, IFN-γ and TNF-α in HPBL and their protein levels in supernatant were significantly increased at 24 h after exposure to 0.05 Gy ¹²C⁶⁺ ions radiation and the effects were stronger than observed for X-ray exposure. However, there was no significant change in the percentage of T and NK cells subsets of HPBL. These results suggested that 0.05 Gy high linear energy transfer (LET) ¹²C⁶⁺ radiation was a more effective approach to host immune enhancement than that of low LET X-ray. We conclude that cytokines production might be used as sensitive indicators of acute response to LDI.     

湿热环境下复合材料层合板本构模型研究及其应用

近年来复合材料被广泛地应用于航空航天等工程领域。在实际的使用中,复合材料在不同的湿热环境下其力学性能会发生显著变化,针对这一问题,国内外已有大量的试验研究,而对湿热环境下复合材料的本构模型理论的研究则较少。在经典层合板理论基础上引入湿热膨胀系数的概念,通过定义一个无量纲的温度,建立材料弹性常数与湿热参数之间的函数关系,推导出复合材料单层板在湿热力耦合作用下的本构关系,同时加入三维Hashin失效判定准则对层合板的损伤演化及失效模式进行模拟。结果表明:该模型较好地预测了复合材料层合板在不同湿热环境下的弹性响应,为分析实际工程中复合材料结构模型在湿热环境下的力学行为提供了重要参考。     

黄金分割自适应鲁棒控制器设计新方法

本文在全系数自适应控制理论基础上,给出了一种实用的黄金分割自适应鲁棒控制器的设计方法及理论分析。对于参数未知、线性定常或慢变的二阶对象,只要参数估计值在一个范围内,该控制器就能保证闭环系统稳定,且系统输出的动态性能较好。从而解决了二阶系统自适应控制在初始过渡过程阶段的实际应用问题。     

新型免抬式电动刀架的研究

本文介绍了一种ＣＮＣ机床新型免抬式电动刀架的机械结构及控制电路。该电动刀架采用梯形螺柱螺套副升降机构,可使刀架转位分度时无需抬起上刀体。刀架转位分度采用机－ 电结合的方法,即先在控制电路中使用霍尔元件进行粗定位,再在机械上采用三齿盘实现精定位。     

数字化环境中型号标准体系建设

对数字化环境中型号标准体系建设的原则以及数字化设计环境下现阶段标准制定、管理办法的编制进行了初步探讨。     

一个用于目标跟踪的改进粒子滤波算法

简化UT（unscented transformation）转化参数,修改UKF（unscented Kalmanfilter）提议分布,提出了改进的粒子滤波算法。调节因子的增加使得能在线自适应估计,滤波性能提高,并形成一个自适应的算法。仅有角测量的目标跟踪仿真试验证实了改进的粒子滤波算法要优于其它滤波方式。     

多维驱动微型振动平台的研制

一种以压电元件为驱动源,结合柔性铰链机构的微型振动平台,通过计算机设计控制电压波形,对其进行三维振动控制.通过实验证明,该机构具有良好的波形跟踪性能,易于实现复杂控制波形,适用于微型机械的动态性能测试.     

DA4169合金高温疲劳裂纹扩展速率

实验研究了直接时效ＤＡ４１６９合金５５０℃、６５０℃下的疲劳裂纹扩展行为,并进行了带上峰值保持时间的试验。结果表明：连续循环的ｄａ／ｄＮ值基本上与普通４１６９的相当,但在６５０℃下略优;６５０℃带上峰值保时１５ｓ的ｄａ／ｄＮ值比连续循环的大大加速。