Skylab experiment results: hematology studies

These studies were designed and coordinated to evaluate specific aspects of man's immunologic and hematologic systems which might be altered by or respond to the space flight environment. The biochemical functions investigated included cytogenetic damage to blood cells, immune resistance to disease, regulation of plasma and red cell volumes, metabolic processes of the red blood cell, and physical chemical aspects of red blood cell functions. Only minor changes were observed in the functional capacity of erythrocytes as determined by measuring the concentrations of selected intracellular enzymes and metabolites. Tests of red cell osmotic regulation indicated some elevation in the activity of the metabolic dependent Na-K pump, with no significant alterations in the cellular Na and K concentrations or osmotic fragility. A transient shift in red cell specific-gravity profile was observed on recovery, possibly related to changes in cellular water content. Measurements of hemoconcentration (hematocrit, hemoglobin concentration, red cell count) indicated significant fluctuations postflight, reflecting observed changes in red cell mass and plasma volume. There was no apparent reticulocytosis during the 18 days following the first manned Skylab mission in spite of a significant loss in red cell mass. However, the reticulocyte count and index did increase significantly 5 to 7 days after completion of the second, longer duration, flight. There were no significant changes in either the while blood cell count or differential. However, the capacity of lymphocytes to respond to an in vitro mitogenic challenge was repressed postflight, and appeared to be related to mission duration. The cause of this repression is unknown at this time. Only minor differences were observed in plasma protein patterns. In the second mission there were changes in the proteins involved in the coagulation process which suggested a hypercoagulative condition.     

Linear FM Signal Formats for Beacon and Communication Systems

This paper examines the capabilities of the class of linear FM spread-spectrum signals within the context of potential communications systems usage in order to establish some performance criteria and bounds that permit comparison with other spread-spectrum formats. A systematic basis is provided for parameter selection for this class of signals by examining the interaction a mong the frequency-modulation indices, time-bandwidth product, and cross-talk criteria that determine the number of effective linear FM signals (or channels) that can be used within the constraints of a bounded time-frequency region. A general expression is derived relating N, the number of useful signals, R2, a cross-talk parameter, ToWo, the mean time-bandwidth product, and ?max and ?min, the maximum and minimum FM rates of the signal set. Canonic signal processor structures are described for ensembles of linear FM signals that have either constant duration or constant bandwidth. It is then shown that the signal modulation format can be modified in accordance with classical paired-echo theory to expand the utility of this class of signals in both synchronous and nonsynchronous operations to yield the equivalent of time-division and code multiplexing. Possible applications for this signal format are discussed.     

Mass spectrometric measurements of stratospheric ions

Recent in situ measurements with balloon borne quadrupole mass spectrometers, between 20 and 45 km altitude, are reviewed and discussed.The major stratospheric positive ions observed are proton hydrates [H⁺(H₂O)_n] and non proton hydrates of the form H⁺X_m(H₂O)₂. The data analysis allows a derivation of the vertical mixing ratio profile of X (most probably CH₃CN), which is compared with recent model calculations. From negative ion composition data, showing the presence of NO₃^? and HSO₄^? cluster ions, the density of sulfuric acid in the stratosphere is deduced. The implications of these findings on our understanding of the sulfur chemistry is briefly treated.Finally some other aspects such as contamination, cluster break up and the use of stratospheric ion mass spectra for determination of thermochemical data and other minor constituents are discussed.     

Microprocessor-Controlled Communications in an Advanced Instrument Landing System

The application of 4-bit microprocessors to the communication of the control and status signals found in an advanced aircraft instrument landing system is presented. The advantages as well as some of the peculiarities of such an approach are described. Among the benefits, one must include the possibility of a very convenient and understandable human interface.     

Hydrodynamic forces resulting from liquid motion in capillary tubes

The wetting kinetics of model tubes of different geometrical shape has been investigated theoretically and experimentally under conditions of simulated zero-gravity (earthbound laboratory experiments) and low gravity (sounding rocket experiments within the TEXUS-programme). The present note deals with the hydrodynamic forces (capillary-, friction-, inertia forces, etc.) resulting from capillary rise in cylindrical, conical and sinusoidal tubes. The rôle of these forces is studied numerically in some detail.     

Long term effects of low doses of 56Fe ions on the brain and retina of the mouse: ultrastructural and behavioral studies.

Eight month old male C57BL6 mice were exposed without anesthesia to whole-body irradiation in circular holders. The mice were tested for behavioral decrements after 0.5 and 50 rads of Fe particle irradiation at 6 and 12 months post irradiation to obtain long term results. A standard maze was used and the animals were timed for completion thereof. A string test also was administered to the mice, testing their ability to grasp and move along a string to safety. The results from animals exposed to 50 rads were significantly different from [correction of fron] control results to p = < .001 in both systems of testing. The hippocampus (believed to be the location of environmental interaction in the brain) and the retina were examined for ultrastructural changes. The ultrastructural changes were similar to those we found in our Cosmos 782, 936 and in our Argon experiments. The mouse data indicate that iron particles were able to induce long term changes in the central nervous system which lead to behavioral impairment.     

Dynamical theory of the solar wind

This paper is a review of the basic theoretical dynamical properties of an atmosphere with an extended temperature strongly bound by gravity. The review begins with the historical developments leading up to the realization that the only dynamical equilibrium of an atmosphere with extended temperature is supersonic expansion. It is shown that sufficient conditions for supersonic expansion are T(r) declining asymptotically less rapidly than 1/r, or the density at the base of the corona being less than N _b given by (40) if no energy is available except through thermal conductivity, or the temperature falling within the limits given by (18) if T N ^-1 throughout the corona. Less extended temperatures lead to equilibria which are subsonic or static. The hypothetical case of a corona with no energy supply other than thermal conduction from its base is considered at some length because the equations may be solved by analytical methods and illustrate the transition from subsonic to supersonic equilibrium as the temperature becomes more extended. Comparison with the actual corona shows that the solar corona is actively heated for some distance into space by wave dissipation.The dynamical stability of the expanding atmosphere is demonstrated, and in a later section the radial propagation of acoustic and Alfvén waves through the atmosphere and wind is worked out. The calculations show that the magnetometer will probably detect waves more easily than the plasma instrument, but that both are needed to determine the mode and direction of the wave. An observer in the wind at the orbit of Earth can listen to disturbances generated in the corona near the sun and in turbulent regions in interplanetary space.The possibility that the solar corona is composed of small-scale filaments near the sun is considered. It is shown that such filamentary structure would not be seen at the orbit of Earth. It is pointed out that the expansion of a non-filamentary corona seems to lead to too high a calculated wind density at the orbit of Earth to agree with the present observations, unless T(r) is constant or increases with r. A filamentary corona, on the other hand, would give the observed wind density for declining T(r).It is shown that viscosity plays no important role in the expansion of an atmosphere either with or without a weak magnetic field. The termination of the solar wind, presumably between 10–10³ AU, is discussed briefly. The interesting development here is the interplanetary L recently observed, which may come from the interstellar neutral hydrogen drifting into the outer regions of the solar wind.Theory is at the present time concerned with the general dynamical principles which pertain to the expansion equilibrium of an atmosphere. It is to be expected that the rapid progress of direct observations of the corona and wind will soon permit more detailed studies to be carried out. It is important that the distinction between detailed empirical models and models intended to illustrate general principles be kept clearly in mind at all times.This work was supported by the National Aeronautics and Space Administration under Grant NASA-NsG-96-60.     

An Analysis of the Performance of the Oscillating Limiter Driven by FM Signals Corrupted by Noise

The behavior of the oscillating limiter (OL) driven by FM signals is surveyed, and its performance with signal corrupted by noise is investigated. For high values of the carrier-to-noise ratio (CNR), if the frequency deviation of the signal is small in comparison with the locking range of the OL, it is calculated, and experimentally verified, that a system OL discriminator is equivalent to a system bandpass limiter discriminator followed by a linear network whose frequency response has been specified. When the frequency deviation is not so small, the baseband noise power increases with it; a formula is given that allows the calculation of this power when the signal is such that the circuit operates in quasistationary fashion. For low values of the CNR, a mathematical analysis presents unsurmountable difficulties. However, heuristic argumentation leads to an interpretation of the operation of the OL in the threshold region, which is substantiated by an experimental investigation. The results of this paper enable a comparative evaluation of a system OL discriminator and a system bandpass limiter discriminator, to which the former reduces when the feedback path in the OL is open.     

Thoracic sonography for pneumothorax: the clinical evaluation of an operational space medicine spin-off

The recent interest in the use of ultrasound (US) to detect pneumothoraces after acute trauma in North America was initially driven by an operational space medicine concern. Astronauts aboard the International Space Station (ISS) are at risk for pneumothoraces, and US is the only potential medical imaging available. Pneumothoraces are common following trauma, and are a preventable cause of death, as most are treatable with relatively simple interventions. While pneumothoraces are optimally diagnosed clinically, they are more often inapparent even on supine chest radiographs (CXR) with recent series reporting a greater than 50% rate of occult pneumothoraces. In the course of basic scientific investigations in a conventional and parabolic flight laboratory, investigators familiarized themselves with the sonographic features of both pneumothoraces and normal pulmonary ventilation. By examining the visceral–parietal pleural interface (VPPI) with US, investigators became confident in diagnosing pneumothoraces. This knowledge was subsequently translated into practice at an American and a Canadian trauma center. The sonographic examination was found to be more accurate and sensitive than CXR (US 96% and 100% versus US 74% and 36%) in specific circumstances. Initial studies have also suggested that detecting the US features of pleural pulmonary ventilation in the left lung field may offer the ability to exclude serious endotracheal tube malpositions such as right mainstem and esophageal intubations. Applied thoracic US is an example of a clinically useful space medicine spin-off that is improving health care on earth.