Induction and repair of DNA strand breaks in bovine lens epithelial cells after high LET irradiation.

The lens epithelium is the initiation site for the development of radiation induced cataracts. Radiation in the cortex and nucleus interacts with proteins, while in the epithelium, experimental results reveal mutagenic and cytotoxic effects. It is suggested that incorrectly repaired DNA damage may be lethal in terms of cellular reproduction and also may initiate the development of mutations or transformations in surviving cells. The occurrence of such genetically modified cells may lead to lens opacification. For a quantitative risk estimation for astronauts and space travelers it is necessary to know the relative biological effectiveness (RBE), because the spacial and temporal distribution of initial physical damage induced by cosmic radiation differ significantly from that of X-rays. RBEs for the induction of DNA strand breaks and the efficiency of repair of these breaks were measured in cultured diploid bovine lens epithelial cells exposed to different LET irradiation to either 300 kV X-rays or to heavy ions at the UNILAC accelerator at GSI. Accelerated ions from Z=8 (O) to Z=92 (U) were used. Strand breaks were measured by hydroxyapatite chromatography of alkaline unwound DNA (overall strand breaks). Results showed that DNA damage occurs as a function of dose, of kinetic energy and of LET. For particles having the same LET the severity of the DNA damage increases with dose. For a given particle dose, as the LET rises, the numbers of DNA strand breaks increase to a maximum and then reach a plateau or decrease. Repair kinetics depend on the fluence (irradiation dose). At any LET value, repair is much slower after heavy ion exposure than after X-irradiation. For ions with an LET of less than 10,000 keV micrometers-1 more than 90 percent of the strand breaks induced are repaired within 24 hours. At higher particle fluences, especially for low energetic particles with a very high local density of energy deposition within the particle track, a higher proportion of non-rejoined breaks is found, even after prolonged periods of incubation. At the highest LET value (16,300 keV micrometers-1) no significant repair is observed. These LET-dependencies are consistent with the current mechanistic model for radiation induced cataractogenesis which postulates that genomic damage to the surviving fraction of epithelial cells is responsible for lens opacification.     

ARTEMIS Mission Design

The ARTEMIS mission takes two of the five THEMIS spacecraft beyond their prime mission objectives and reuses them to study the Moon and the lunar space environment. Although the spacecraft and fuel resources were tailored to space observations from Earth orbit, sufficient fuel margins, spacecraft capability, and operational flexibility were present that with a circuitous, ballistic, constrained-thrust trajectory, new scientific information could be gleaned from the instruments near the Moon and in lunar orbit. We discuss the challenges of ARTEMIS trajectory design and describe its current implementation to address both heliophysics and planetary science objectives. In particular, we explain the challenges imposed by the constraints of the orbiting hardware and describe the trajectory solutions found in prolonged ballistic flight paths that include multiple lunar approaches, lunar flybys, low-energy trajectory segments, lunar Lissajous orbits, and low-lunar-periapse orbits. We conclude with a discussion of the risks that we took to enable the development and implementation of ARTEMIS.     

The Low Metallicity Tail of the Halo Metallicity Distribution Function

Ongoing spectroscopy and photometry of stars selected in the HK objective-prism/interference-filter survey of Beers and colleagues has resulted in the identification of many hundreds of additional stars in the halo (and possibly the thick disk) of the Galaxy with abundances [Fe/H] -2.0. A new calibration of the technique for estimation of metal abundance based on a CaII K index as a function of broadband B - V color is applied to obtain metallicities for stars observed with the SSO 2.3m and INT 2.5m telescopes. This new data is combined with other samples of extremely metal-deficient stars (Ryan and Norris, 1991a; Beers et al., 1992; Carney et al., 1994) to form a large database of objects of low metallicity. The combined sample is examined and compared with expectations derived from a Simple Model of Galactic chemical evolution. There appears to be a statistically-significant deficit of stars more metal-weak than [Fe/H] = -3.0. An abundance of [Fe/H] -4.0 can be taken as the low-metallicity limit for presently-observable stars in the Galaxy.     

喷流对飞机尾流涡影响的试验研究

飞机产生的尾流涡,特别是大尺度的翼尖涡,对尾随其后的飞行器是非常有害的,本文旨在探索利用飞机发动机产生的喷流加速尾流涡消亡的方法。试验采用简化的飞机模型(有尾翼),建立了包含一对翼尖涡及一对反向旋转的尾翼涡(通过以负迎角安装尾翼得到)的4涡尾流系统。在无外来扰动的情况下,不同的尾翼设置下得到的尾翼涡对翼尖涡的作用效果不同,有的能导致翼尖涡提前消亡,有的则不能。考察了不同强度的喷流对不同4涡尾流系统的影响,且作为对比,对无尾翼(2涡系统)及无喷流下的各种情况也分别作了观测。试验在拖曳水槽中进行,运用体视粒子图像测速(SPIV)技术,观测了与模型拖曳方向垂直的、从机翼后缘到下游约45翼展间均布的一系列切面。结果表明:当喷流直接作用于涡时,其效果主要取决于两者之间的初始距离及相对强度;而当喷流作用于整个4涡尾流系统时,其引入的扰动对不同的系统均能起到一定程度的改善作用,这种作用的关键在于利用喷流优化对翼尖涡进行扰动的机制,而不仅仅取决于喷流的强度。     

XMM-Newton study of soft excess X-ray emission in clusters of galaxies

We discuss the detection of soft excess X-ray emission in a sample of 19 clusters of galaxies observed by XMM-Newton. In 6/19 clusters evidence for a soft X-ray excess is found. Four of these clusters show soft X-ray and O VII line emission from gas with a temperature of 0.2 keV. The centroid of this oxygen line is consistent with the redshift of the cluster. The intensity and spatial extend of the soft excess agrees with previous PSPC measurements. These observations are interpreted as emission from warm-hot intergalactic medium filaments, with density enhancements near the cluster centers, consistent with theoretical predictions. In the other two soft excess clusters a non-thermal origin is consistent with the data.     

Confronting Observations and Modeling: The Role of the Interstellar Magnetic Field in Voyager 1 and 2 Asymmetries

Magnetic effects are ubiquitous and known to be crucial in space physics and astrophysical media. We have now the opportunity to probe these effects in the outer heliosphere with the two spacecraft Voyager 1 and 2. Voyager 1 crossed, in December 2004, the termination shock and is now in the heliosheath. On August 30, 2007 Voyager 2 crossed the termination shock, providing us for the first time in-situ measurements of the subsonic solar wind in the heliosheath. With the recent in-situ data from Voyager 1 and 2 the numerical models are forced to confront their models with observational data. Our recent results indicate that magnetic effects, in particular the interstellar magnetic field, are very important in the interaction between the solar system and the interstellar medium. We summarize here our recent work that shows that the interstellar magnetic field affects the symmetry of the heliosphere that can be detected by different measurements. We combined radio emission and energetic particle streaming measurements from Voyager 1 and 2 with extensive state-of-the art 3D MHD modeling, to constrain the direction of the local interstellar magnetic field. The orientation derived is a plane ～60°–90° from the galactic plane. This indicates that the field orientation differs from that of a larger scale interstellar magnetic field, thought to parallel the galactic plane. Although it may take 7–12 years for Voyager 2 to leave the heliosheath and enter the pristine interstellar medium, the subsonic flows are immediately sensitive to the shape of the heliopause. The flows measured by Voyager 2 in the heliosheath indicate that the heliopause is being distorted by local interstellar magnetic field with the same orientation as derived previously. As a result of the interstellar magnetic field the solar system is asymmetric being pushed in the southern direction. The presence of hydrogen atoms tend to symmetrize the solutions. We show that with a strong interstellar magnetic field with our most current model that includes hydrogen atoms, the asymmetries are recovered. It remains a challenge for future works with a more complete model, to explain all the observed asymmetries by V1 and V2. We comment on these results and implications of other factors not included in our present model.