X-ray induced alterations in the differentiation and mineralization potential of murine preosteoblastic cells

To evaluate the effects of ionizing radiation (IR) on murine preosteoblastic cell differentiation, we directed OCT-1 cells to the osteoblastic lineage by treatment with a combination of β-glycerophosphate (β-GP), ascorbic acid (AA), and dexamethasone (Dex). In vitro mineralization was evaluated based on histochemical staining and quantification of the hydroxyapatite content of the extracellular bone matrix. Expression of mRNA encoding Runx2, transforming growth factor β1 (TGF-β1), osteocalcin (OCN), and p21^CDKN1A was analyzed. Exposure to IR reduced the growth rate and diminished cell survival of OCT-1 cells under standard conditions. Notably, calcium content analysis revealed that deposition of mineralized matrix increased significantly under osteogenic conditions after X-ray exposure in a time-dependent manner. In this study, higher radiation doses exert significant overall effects on TGF-β1, OCN, and p21^CDKN1A gene expression, suggesting that gene expression following X-ray treatment is affected in a dose-dependent manner. Additionally, we verified that Runx2 was suppressed within 24 h after irradiation at 2 and 4 Gy. Although further studies are required to verify the molecular mechanism, our observations strongly suggest that treatment with IR markedly alters the differentiation and mineralization process of preosteoblastic cells.     

Simulation of the flow around a stationary circular cylinder taking into account laminar-turbulent transition

We consider a problem of a stationary incompressible viscous fluid flow around a flat circular cylinder. In the vicinity of the critical Reynolds number Re _cr a stepwise drop of the cylinder drag takes place, which is called the drag crisis.     

Energy Release and Particle Acceleration in Flares: Summary and Future Prospects

RHESSI measurements relevant to the fundamental processes of energy release and particle acceleration in flares are summarized. RHESSI??s precise measurements of hard X-ray continuum spectra enable model-independent deconvolution to obtain the parent electron spectrum. Taking into account the effects of albedo, these show that the low energy cut-off to the electron power-law spectrum is typically ?tens of keV, confirming that the accelerated electrons contain a large fraction of the energy released in flares. RHESSI has detected a high coronal hard X-ray source that is filled with accelerated electrons whose energy density is comparable to the magnetic-field energy density. This suggests an efficient conversion of energy, previously stored in the magnetic field, into the bulk acceleration of electrons. A new, collisionless (Hall) magnetic reconnection process has been identified through theory and simulations, and directly observed in space and in the laboratory; it should occur in the solar corona as well, with a reconnection rate fast enough for the energy release in flares. The reconnection process could result in the formation of multiple elongated magnetic islands, that then collapse to bulk-accelerate the electrons, rapidly enough to produce the observed hard X-ray emissions. RHESSI??s pioneering ??-ray line imaging of energetic ions, revealing footpoints straddling a flare loop arcade, has provided strong evidence that ion acceleration is also related to magnetic reconnection. Flare particle acceleration is shown to have a close relationship to impulsive Solar Energetic Particle (SEP) events observed in the interplanetary medium, and also to both fast coronal mass ejections and gradual SEP events. New instrumentation to provide the high sensitivity and wide dynamic range hard X-ray and ??-ray measurements, plus energetic neutral atom (ENA) imaging of SEPs above ??2 R_??, will enable the next great leap forward in understanding particle acceleration and energy release is large solar eruptions??solar flares and associated fast coronal mass ejections (CMEs).     

Local fracture of the burning solid propellant

The problem of fracture mechanics for the solid propellant deteriorated by a crack-shaped cavity, the surface of which burns is considered. It is assumed that the propellant reagents are uniformly distributed in the solid phase while the combustion products are gaseous. The sufficient condition for the “combustion -fracture” stability regime is obtained.     

A DORIS determination of the absolute velocities of the Sorsdal and Mellor glaciers in Antarctica

The Lambert–Amery System is the largest glacier–ice shelf system in East Antarctica, draining a significant portion of the ice sheet. Variation in ice sheet discharge from Antarctica or Greenland has an impact on the rate of change in global mean sea level; which is a manifestation of climate change. In conjunction with a measure of ice thickness change, ice sheet discharge can be monitored by determining the absolute velocities of these glaciers.     

Solar activity dependence of total electron content derived from GPS observations over Mbarara

Vertical total electron content (VTEC) observed at Mbarara (geographic co-ordinates: 0.60°S, 30.74°E; geomagnetic coordinates: 10.22°S, 102.36°E), Uganda, for the period 2001–2009 have been used to study the diurnal, seasonal and solar activity variations. The daily values of the 10.7 cm radio flux (F_10.7) and sunspot number (R) were used to represent Solar Extreme Ultraviolet Variability (EUV). VTEC is generally higher during high solar activity period for all the seasons and increases from 0600 h LT and reaches its maximum value within 1400 h–1500 h LT. All analysed linear and quadratic fits demonstrate positive VTEC-F_10.7 and positive VTEC-R correlation, with all fits at 0000 h and 1400 h LT being significant with a confidence level of 95% when both linear and quadratic models are used. All the fits at 0600 h LT are insignificant with a confidence level of 95%. Generally, over Mbarara, quadratic fit shows that VTEC saturates during all seasons for F_10.7 more than 200 units and R more than 150 units. The result of this study can be used to improve the International Reference Ionosphere (IRI) prediction of TEC around the equatorial region of the African sector.     

A mission template for exploration and damage mitigation of potential hazard of Near Earth Asteroids

The Apophis Exploratory and Mitigation Platform (AEMP) concept was developed as a prototype mission to explore and potentially deflect the Near Earth Asteroid (NEA) 99942 Apophis. Deflection of the asteroid from the potential 2036 impact will be achieved using a gravity tractor technique, while a permanent deflection, eliminating future threats, will be imparted using a novel albedo manipulation technique. This mission will serve as an archetypal template for future missions to small NEAs and could be adapted to mitigate the threat of collision with other potential Earth-crossing objects.     

Near-real time monitoring of the TEC fluctuations over the northern hemisphere using GNSS permanent networks

Since the early 1990s, global positioning system measurements have been used to study of the state and rapid changes of the Total Electron Content in the ionosphere. Currently, the increasing number of permanent stations makes it possible to generate maps of the irregularities in the ionosphere for specified regions with sub-daily resolution. The main goal of this work was to apply global navigation satellite system observations to obtain information about ionospheric variability around the North Geomagnetic Pole. In order to detect the ionospheric disturbances, 30-s observation data was used. The Rate of Total Electron Content Index was applied as a measure of the variability in the ionosphere. The first analyses were executed using more than 100 permanent stations. The results show two kinds of products: 2-hour maps in spherical geomagnetic coordinates and daily maps presenting the occurrence of the strong Total Electron Content fluctuations as a magnetic local time function, for the most disturbed days of April 2010. Apart from the main product of the algorithm, the Rate of Total Electron Content time series for individual satellite tracks was presented. The results demonstrated very good sensitivity of the obtained maps, which can detect even quite weak disturbances. The presented algorithm developed at the Geodynamic Research Laboratory of the University of Warmia and Mazury, in cooperation with Institute of Terrestrial Magnetism, Ionosphere and Radiowave Propagation, will be applied in the near future to create near-real time service of the conditions in the ionosphere based on the Global Navigation Satellite Systems observations.     

Programmable, multi-purpose opto-electronic sensor system

Optical fibre sensing is becoming increasingly attractive in both the smart structure sphere of interest as well as the medical and industrial concerns. Fibre-optic interferometric sensors can be designed as compact and robust transducers. In general, the transduction mechanism involves the phase modulation of coherent or monochromatic light propagating through a fibre-optic cable, and detecting the changes in the energy associated with this phase change. Sensors based on this technique can generally be configured to be quite sensitive and measurements of a wide variety of physical parameters are achievable. Intrinsic features of optical fibres, such as immunity to electromagnetic interference, flexibility, thinness, strength and weight, make this ideal for sensor technology. In the process of developing fibre-optic sensors for laboratory experimentation, as well as generalised research, an appropriate, easy to use opto-electronic drive and measurement system is required. This paper discusses the operation of a programmable opto-electronic drive and measurement system     

The Sun's Role in Long-Term Climate Change

Evidence suggests that changes of solar irradiance in recent centuries have provided a significant climate forcing and that the sun has been one of the principal causes of long-term climate change. During the past two decades the solar forcing has been much smaller than the climate forcing caused by increasing greenhouse gases. But it is incorrect to assume that the sun necessarily will be an insignificant player in climate change of the 21st century. Indeed, I argue that moderate success in curtailing the growth of anthropogenic climate forcings could leave the sun playing a pivotal role in future climate change.