The effects of microgravity on the skeletal system--a review

Exposure of astronauts to microgravity leads to the loss of calcium from weightbearing bones. Prolonged exposure, e.g., during a journey to Mars, may present problems on return to Earth, with increased risk of fractures and premature osteoporosis in later life. The precise mechanisms of calcium loss have yet to be determined although a key feature is the absence of mechanical loading. Countermeasures aimed at reducing calcium loss to acceptable levels include the use of exercise, drugs, dietary modifications and inertia suits such as the Soviet "Penguin" suit. Missions of a number of years may, however, require the development of artificial gravity on a spacecraft. The country that first solves the physiological problems of man in space and, in particular, skeletal calcium loss, will almost certainly be the first to be able to put a man on Mars.     

Exercise response to simulated weightlessness

Two bed rest analog studies of space flight were performed; one 14 d and the other 28 d in duration. Exercise response was studied in detail during the 28 d study and following both the 14 d and 28 d studies. This paper relates the results of these studies to physiologic changes noted during and following space flight. The most consistent change noted after both bed rest and space flight is an elevated heart rate during exercise. A second consistent finding is a postflight or postbed rest reduction in cardiac stroke volume. Cardiac output changes were variable. The inability to simulate inflight activity levels and personal exercise makes a direct comparison between bed rest and the results from specific space flights difficult.     

Structural and functional changes in man accompanying the weightlessness in "Skylab" flights: a mathematical approach

The present paper reports a kinetic analysis of changes of some physiological parameters, obtained from international literature, after changes in gravitational environment. The overall phenomenology of the adaptation to weightlessness is characterized by a rapid process followed by a slow one. The two processes show half time values differing by about five times. Also in the case of readaptation to gravity, after recovery on the Earth, two well resolved processes, showing different half time values, are observed. It is of interest to notice that the rate of response to weightlessness is lower than that to gravity. Of course, the half time values observed depend on the different physiological parameters considered. In any case, the experimental data suggest a general trend of many adaptive changes, that may all be described by a simple mathematical model.     

Mineral and nitrogen balance study: results of metabolic observations on Skylab II 28-day orbital mission

Prediction that the various stresses of flight, particularly weightlessness, would bring about significant derangements in the metabolism of the musculoskeletal system has been based on various observations of long-term immobilized or inactive bed rest. The only attempt at controlled measurement of metabolic changes in space prior to Skylab, a study during the 14-day Gemini VII flight, revealed rather modest losses of important elements. The three astronauts of Skylab II consumed a planned day-by-day, quite constant, dietary intake of major metabolic elements in mixed foods and beverages and provided virtually complete collections of excreta for 31 days preflight, during the 28 days inflight, and for 17 days postflight. Analyses showed that, in varying degree among the crewmen, urinary calcium increased gradually during flight in a pattern similar to that observed in bed-rest studies: the mean plateau peak of urinary calcium excretion in the latter part of flight was double preflight levels. Fecal calcium excretion did not change significantly, but calcium balance, owing to the urinary calcium rise, became either negative or less positive than in preflight measurement. Increased excretion and negative balance of nitrogen and phosphorus indicated appreciable loss of muscle tissue in all three crewmen. Significant losses also occurred inflight in potassium, sodium, and magnesium. Based on the similarity in pattern and degree between these observations and those in bed rest of the losses in calcium, phosphorus, and nitrogen, musculoskeletal integrity would not be threatened in space flights of up to at least 3 months. However, if similar changes occur, indicative of continuing losses of these elements, in the planned Skylab flights for considerably more than 28 days, concern for capable musculoskeletal function should be serious for flights of very many months' duration, and greater research attention will need to be given to development of protective counter-measures.     

Effect of fluid and salt supplements in preventing the development of "osteopenia" in hypokinetic rats

It has been suggested that a daily intake of fluid and salt supplements may be used to prevent bone demineralization in human subjects after prolonged exposure to hypokinesia (diminished muscular activity). Thus, the objective of this investigation was to evaluate the effect of fluid and salt supplementation in the prevention of development of osteoporosis in 64 Wistar rats with an initial body weight of 339-345 g, after exposure to 90 days of hypokinesia. They divided into 4 equal groups: the first group of rats placed under ordinary vivarium conditions and served as vivarium control; the second group were also placed under ordinary vivarium conditions but received daily fluid and salt supplements; the third group were subjected to pure hypokinesia, i.e. without the use of any preventive measures; and the fourth group were submitted to hypokinesia and received daily fluid and salt supplements. For the simulation of the hypokinetic effect the experimental group of rats were kept in small, individual, wooden cages. Through the experimental period the second and fourth group of rats received 8 ml/100 g body wt water and 5 ml 100 g body wt NaCl daily. By the end of the experimental period the animals were decapitated and the spongy matter of tibia and vertebrae of the rats were examined for changes referable to osteoporosis. It was found that the daily intake of fluid and salt supplements caused an increase in the volume density of primary spongiosa of bones. It was concluded that a daily intake of fluid and salt supplements may be used to prevent the development of osteoporosis in rats subjected to prolonged motor activity restriction.     

Precipitating Protons and Their Role in Ionization of the Polar Ionosphere

Spatial distributions of the electron density in the latitude range 60°–90° N were calculated on the basis of a physical model of the E and lower Fregions of the high-latitude ionosphere using statistical models of auroral proton and electron precipitation. It is shown that precipitating protons can play the key role in the ionization of the Eregion in the dusk and midnight sectors of the auroral oval. However, quantitative estimates of the contribution of protons to the ionization depend on the used statistical models of electron precipitation. Comparison of the electron density profiles calculated for two incoherent scatter radars, EISCAT (Tromsö) and ESR (Svalbard), for simultaneous precipitation of electrons and protons and for electron precipitation only show that the influence of protons is the most significant in the dusk sector over the EISCAT radar and in the midnight sector over the ESR radar. The results presented indicate the need to take protons into account when radar data are used to derive precipitating electron spectra.     

The Brazilian scientific microsatellite SACI-1

The National Space Research Institute (INPE) is developing the first Brazilian Scientific Microsatellite (SACI-1) based on the vanguard technology and on the experience acquired through projects developed by Brazilian Space Program. The SACI-1 is a 750km polar orbit satellite. The spacecraft will combine spin stabilization with geomagnetic control and has a total mass of 60 kg. The overall dimensions are 640×470×470 mm. The SACI-1 satellite shall be launched together with CBERS (China-Brazil Earth Resource Satellite). Its platform is being designed for multiple mission applications. The Brazilian Academy of Sciences has selected four scientific payloads that characterize the mission. The scientific experiments are: ORCAS (Solar and Anomalous Cosmic Rays Observation in the Magnetosphere), PLASMEX (Study of Plasma Bubbles), FOTSAT (Airglow Photometer), and MAGNEX (Geomagnetic Experiment).     

Operational continuity of the global meteorological satellite network

The global network of meteorological satellites used different forms of international cooperation during its development, and some of these forms continue. Concern about continued operation of the global network led the WMO to study the issues and to adopt a long-term policy and strategy based on a shared meteorological satellite network. Nations need to consider how to combine their meteorological and space-related organizations in a partnership role, so they can directly contribute to a future global network of meteorological satellites. Some examples are cited to demonstrate that increased direct participation is a valid and feasible objective.     

Anesthesia, surgical aid and resuscitation in manned space missions.

When discussing problems related to medical service in space flight, particular attention should be given to the specific living conditions and changes associated with space flight. In disease and injury, surgery can be provided only after conservative therapy has failed. In this context gnotobiological chambers allowing surgery in aseptic conditions seem promising. A portable set of interchangeable surgical tools should be made of light-weight alloys that can be readily sterilized. Electroanalgesia in combination with auriculoacupuncture as well as peridureal anesthesia may be used as they allow normal operations in autonomous space flight conditions. Changes in the sympatho-adrenal and kallikrein-kinin systems, as well as water-electrolyte balance, should be taken into account in developing methods and means of medical service in critical situations. Special attention should be given to the prevention and treatment of brain edema in view of weightlessness-induced cephalad fluid shifts.     

Phugoid oscillations in optimal reentry trajectories

A major problem with operations of lifting reentry vehicle having an aft center-of-gravity location due to large engine mass at the rear is the required hypersonic trim to fight the desired trajectory. This condition is most severe for lifting maneuvers. As a first step toward analyzing this problem, this paper considers the lift requirement for some basic maneuvers in the plane of a great circle. Considerations are given to optimal lift control for achieving the maximization of either the final altitude, speed or range. For the maximum-range problem, phugoid oscillation along an optimal trajectory is less severe as compared to a glide with maximum lift-to-drag ratio. An explicit formula for the number of oscillations for an entry from orbital speed is proposed.