Neutral buoyancy and sleep-deprived serum factors alter expression of cytokines regulating osteogenesis

We examined expression of genes associated with cytokine production, and genes implicated in regulating bone metabolism, in bone stromal and osteoblast cells incubated under standard ground conditions and under conditions of neutral buoyancy, and in the presence/absence of serum from normal or sleep-deprived mice. We observed a clear interaction between these two conditions (exposure to neutral buoyancy and serum stimulation) in promoting enhanced osteoclastogenesis. Both conditions independently altered expression of a number of cytokines implicated in the regulation of bone metabolism. However, using stromal cells from IL-1 and TNFx cytokine(r) KO mice, we concluded that the increased bone loss under microgravity conditions was not primarily cytokine mediated.     

Intelsat's next generation satellite for the Americas

In order to meet the growing demand for high performance C- and Ku-Band services in the Americas, INTELSAT contracted with Astrium in February 2000 to procure a high capacity communications spacecraft for its 310°E operational location. The spacecraft platform is based on Astrium's next generation platform, the Eurostar 3000. Several new technologies such as integrated Data Handling System, Plasma Propulsion System, etc. are integral features of this platform. The communication payload comprises 36 C-Band and 20 high power Ku-Band transponders. The beam coverages are tailored for the 310°E orbital location and are implemented using a hybrid shaped antenna design approach, where multiple C-Band coverages are generated from a single shaped reflector utilizing a pair of Tx/Rx feed horns for each coverage. The Ku-Band coverages are generated by the classical dual Gregorian shaped reflector antenna design approach. With a total dry mass on the order of 2650 kg and a separated launch mass of 5400 kg, the spacecraft is compatible with most of the available launch vehicles providing mission life of greater than 13 years. The paper will provide technical details of the spacecraft.     

A non-earthcentric approach to life detection

The ultimate goal of a comprehensive life detection strategy is never to miss life when we encounter it. To accomplish this goal, we must define life in universal, that is, non-Earthcentric, measurable terms. Next, we must understand the nature of biosignatures observed from the measured parameters of life. And finally, we must have a clear idea of the end-member states for the search--what does life, past life, or no life look like (in terms of the measured parameters) at multiple spatial and temporal scales? If we can approach these problems both in the laboratory and in the field on Earth, then we have a chance of being able to detect life elsewhere in our solar system. What are the required limits of detection at each of those scales? What spatial, spectral, and temporal resolutions are necessary to detect life? These questions are actively being investigated in our group, and in this report, we present our strategy and approach to non-Earthcentric life detection.     

A Series of Proton Flares in July 1985 from Observations by the Prognoz-10 Satellite and Vega-1, 2 Spacecraft

The enhancements of solar protons with an energy of more than 30 MeV, originating from flares in one active region and observed simultaneously aboard three spacecraft Vega-1, 2 and Prognoz-10 in July 1985, are analyzed and approximated in this work by using the reflection model [2]. The numerical values of several physical parameters (the parameters of distribution of solar cosmic ray (SCR) particles inside heliosphere traps, the coefficients of trap transparency) that are not observed by direct measurements are estimated.     

On Solvable Models of Electrostatic Double Layers

We describe models of weak electrostatic double layers in unmagnetized plasma. After a short review of early models we concentrate on the BGK equilibria corresponding to double layer potentials. For such systems we present methods of analyzing stability with respect to high frequency perturbations.     

Specification and Performance of Passive Sonar Spectral Estimators

The application of existing estimation theory to the problem of specification and performance of passive sonar spectral estimators is considered. The classification function is addressed, so that the signal is assumed to be present, and so that the energy arrival angle is known. The spatial filter considered is a line array of M equally spaced omnidirectional hydrophones. Signal and ambient noise are both zero-mean, wide-sense, stationary Gaussian random processes that differ in their spatial correlation across the face of the array. The signal is a plane wave that can be made totally spacially corrected between array elements by inserting delays between sensors to invert the signal propagation delay. The noise correlation is a function of frequency, bandwidth, element separation, and the relative time delay between sensors. Under these assumptions, the Cramer-Rao lower bound is derived for the class of unbiased estimates of signal power in a narrow frequency band at the hydrophone in the presence of correlated ambient noise of known power. The bound is examined numerically, resulting in a threshold phenomenon with M that constitutes a new design consideration. In addition, there is a striking insensitivity to realistic values of ambient noise correlation, and there are ranges in signal-to-noise ratio for which one gains more by increasing M than by increasing the bandwidth-time product. Specific processors, including a new unbiased estimator when noise power is unknown, are developed.     

Overlapping search with scanned beam applications

Acquisition and false acquisition probabilities are derived for search including overlap between observation regions. (Gap-free search, important in many applications, frequently involves overlap.) Search patterns are included, together with system parameters and observation sequences minimizing search time. Design curves applicable to laser, radar, sonar, and other methods are used in practical examples. These examples, accounting for beam shape and receiver characteristics, show that the small overlap in these patterns compensates for beam edge effects     

PMHT: problems and some solutions

The probabilistic multihypothesis tracker (PMHT) is a target tracking algorithm of considerable theoretical elegance. In practice, its performance turns out to be at best similar to that of the probabilistic data association filter (PDAF); and since the implementation of the PDAF is less intense numerically the PMHT has been having a hard time finding acceptance. The PMHT's problems of nonadaptivity, narcissism, and over-hospitality to clutter are elicited in this work. The PMHT's main selling-point is its flexible and easily modifiable model, which we use to develop the "homothetic" PMHT; maneuver-based PMHTs, including those with separate and joint homothetic measurement models; a modified PMHT whose measurement/target association model is more similar to that of the PDAF; and PMHTs with eccentric and/or estimated measurement models. Ideally, "bottom line" would be a version of the PMHT with clear advantages over existing trackers. If the goal is of an accurate (in terms of mean square error (MSE)) track, then there are a number of versions for which this is available.     

Medium PRF set selection using evolutionary algorithms

This paper presents a new and novel method of selecting multiple pulse repetition frequency (PRF) sets for use in medium PRF pulsed-Doppler radars. Evolutionary algorithms are used to minimise the blind areas in the range/Doppler space. The evolutionary algorithm allows optimal solutions to be generated quickly, far faster than with exhaustive searches, and is fully automatic, unlike existing techniques. The evolved solutions compare very favorably against the results of both an exhaustive search and existing published PRF set selection methods. This evolutionary approach to generation of PRF sets is a major advance in medium PRF radar design.