Cellular responses to gravity: extracellular, intracellular and in-between.

Our understanding of gravitational effects (inertial effects in the vicinity of 1 x g) on cells has matured to a stage at which it is possible to define, on the basis of experimental evidence, extracellular effects on small cells and intracellular effects on eukaryotic gravisensing cells. Yet undetermined is the nature of response, if any, of those classes of cells that are not governed solely by extracellular physical events (as are prokaryotes) and are devoid of obvious mechanical devices for sensing inertial forces (such as those possessed by certain plant cells and sensory cells of animals). This "in-between" class of cells needs to be understood on the basis of the combination of intracellular and extracellular gravity-dependent processes that govern experimentally-measurable variables that are relevant to the cell's responses to modified inertial forces. The forces that certain cell types generate or respond to are therefore compared to those imposed by approximately 1 x g in the context of cytoskeletal action and symmetry-breaking pathways.     

Variations in statistical parameters of the NmF2 equinoctial asymmetry with latitude and solar activity near noon

Hourly values of the F2-layer peak density, NmF2, measured by 95 ionosondes near noon from 1957 to 2011 at low and middle geomagnetic latitudes of the northern and southern geographic hemispheres are used in a statistical study of the NmF2 equinoctial asymmetry. The ratios, R, of NmF2 measured during 61 days around the March equinox to NmF2 measured during 61 days around the September equinox at the same UT near noon during geomagnetically quiet daytime conditions for approximately the same solar activity conditions over the same ionosonde are analyzed. The conditional probability of the occurrence of R in an interval of R, the most probable value of R, and the mean expected value of R are calculated for the first time for the low, moderate, and high solar activity levels to study variations in these statistical parameters with latitude and solar activity. These statistical parameters are averaged over 5° geomagnetic latitude interval in the northern and southern geographic hemispheres to calculate and to study for the first time trends in latitude and solar activity of these averaged NmF2 equinoctial asymmetry statistical characteristics.     

Improved predictions of equatorial TEC for real time applications

It is important to use models developed specifically for the equatorial ionospheric estimation for real-time applications, particularly in Satellite Navigation. This work demonstrates a methodology for improved predictions of VTEC in real time using the model developed for the equatorial ionosphere by the authors. This work has been done using TEC data of the low solar activity period of 2005 obtained using dual frequency GPS receivers installed under the GAGAN project of ISRO. For the purpose, the model is first used in conjunction with Kriging technique. Improvement in accuracy is observed when compared with the estimations from the model alone using the measurements as true reference. Further improvement is obtained by Bayesian combination of these estimates with independent Neural Network based predictions. Statistical performance of improvement is provided. An improvement of ∼1 m in confidence level of estimation of VTEC is obtained.     

Emesis and space motion sickness in amphibians.

Amphibians possess the ability to vomit in response to a variety of stimuli that provoke emesis in mammals. Pharmacological studies have establish that the ejection of gastric contents and the basic mechanism for vomiting have been phylogenetically conserved among these tetrapods. As part of on-going comparative studies on emesis in vertebrates, we previously documented that some postmetamorphic anurans and salamander larvae experience motion-induced emesis when exposed to the provocative stimulus of parabolic aircraft flight. However, more recent experiments suggest that there are strict conditions for inducing emesis in amphibians exposed to parabolic flight and that amphibians are not as sensitive to this stimulus as mammals. Further studies on emesis in lower vertebrates may help us understand the processes that cause emesis in abnormal gravitational regimes.     

Determination of parameters of rotational motion of the <Emphasis Type="Italic">Monitor-E</Emphasis> spacecraft from the telemetry data on solar batteries’ current

The Monitor-E spacecraft executed uncontrolled flight due to emergency situation, no telemetry information on parameters of the spacecraft’s attitude motion being available. So, the problem arose to determine the spacecraft’s rotational motion from the accessible indirect information—the electric current provided by solar batteries. In this paper the integrated statistical technique is described, that allows one to solve this problem. The values of current, obtained over the time interval some tens of minutes long, have been processed simultaneously by the least squares method using the integration of the equations of spacecraft’s rotational motion. As a result of processing, the initial conditions of motion were estimated, and the spacecraft’s moments of inertia were updated, as well as the angles, specifying solar batteries position in the spacecraft-fixed coordinate system. The results of processing of 12 data sets are presented, which allowed us to reconstruct the actual rotational motion of the spacecraft.     

Harnessing functional food strategies for the health challenges of space travel—Fermented soy for astronaut nutrition

Astronauts face numerous health challenges during long-duration space missions, including diminished immunity, bone loss and increased risk of radiation-induced carcinogenesis. Changes in the intestinal flora of astronauts may contribute to these problems. Soy-based fermented food products could provide a nutritional strategy to help alleviate these challenges by incorporating beneficial lactic acid bacteria, while reaping the benefits of soy isoflavones. We carried out strain selection for the development of soy ferments, selecting strains of lactic acid bacteria showing the most effective growth and fermentation ability in soy milk (Streptococcus thermophilus ST5, Bifidobacterium longum R0175 and Lactobacillus helveticus R0052). Immunomodulatory bioactivity of selected ferments was assessed using an in vitro challenge system with human intestinal epithelial and macrophage cell lines, and selected ferments show the ability to down-regulate production of the pro-inflammatory cytokine interleukin-8 following challenge with tumour necrosis factor-alpha. The impact of fermentation on vitamin B1 and B6 levels and on isoflavone biotransformation to agluconic forms was also assessed, with strain variation-dependent biotransformation ability detected. Overall this suggests that probiotic bacteria can be successfully utilized to develop soy-based fermented products targeted against health problems associated with long-term space travel.     

Estimating matched filter amplitude probability functions byfailure rate analysis

Performance analysis of echolocation systems requires knowledge of the probability density function (pdf) or cumulative distribution function (cdf) of a matched filter output. A method is presented to estimate these and other probability functions from data by estimating the failure rate function, a function employed in reliability theory. The method can also be used to derive approximations to closed-form probability functions. The method is demonstrated using experimental sonar and radar clutter data and a closed-form radar clutter model     

Identification of Aircraft Stability and Control Parameters Using Hierarchical State Estimation

Previous attempts to identify aircraft stability and control derivatives from flight test data, using three-degrees-of-freedom (3-DOF) longitudinal or lateral-directional perturbation equation-of-motion models, suffer from the disadvantage that the coupling between the longitudinal and lateral-directional dynamics has been ignored. In this paper, the identification of aircraft stability parameters is accomplished using a more accurate 6-DOF model which includes this coupling. Hierarchical system identification theory is used to reduce the computational effort involved. The 6-DOF system of equations is first decomposed into two 3-DOF subsystems, one for the longitudinal dynamics and the other for the lateral-directional dynamics. The two subsystem parameter identification processes are then coordinated in such a way that the overall system parameter identification problem is solved. Next, a six-subsystem decomposition is considered. Computational considerations and comparison with the unhierarchically structured problem are presented.