Tissue responses to low protracted doses of high LET radiations or photons: early and late damage relevant to radio-protective countermeasures.

Early and late murine tissue responses to single or fractionated low doses of heavy charged particles, fission-spectrum neutrons or gamma rays are considered. Damage to the hematopoietic system is emphasized, but results on acute lethality, host response to challenge with transplanted leukemia cells and life-shortening are presented. Low dose rates per fraction were used in some neutron experiments. Split-dose lethality studies (LD 50/30) with fission neutrons indicated greater accumulation of injury during a 9 fraction course (over 17 days) than was the case for gamma-radiation. When total doses of 96 or 247 cGy of neutrons or gamma rays were given as a single dose or in 9 fractions, a significant sparing effect on femur CFU-S depression was observed for both radiation qualities during the first 11 days, but there was not an earlier return to normal with dose fractionation. During the 9 fraction sequence, a significant sparing effect of low dose rate on CFU-S depression was observed in both neutron and gamma-irradiated mice. CFU-S content at the end of the fractionation sequence did not correlate with measured LD 50/30. Sustained depression of femur and spleen CFU-S and a significant thrombocytopenia were observed when a total neutron dose of 240 cGy was given in 72 fractions over 24 weeks at low dose rates. The temporal aspects of CFU-S repopulation were different after a single versus fractionated neutron doses. The sustained reduction in the size of the CFU-S population was accompanied by an increase in the fraction in DNA synthesis. The proliferation characteristics and effects of age were different for radial CFU-S population closely associated with bone, compared with the axial population that can be readily aspirated from the femur. In aged irradiated animals, the CFU-S proliferation/redistribution response to typhoid vaccine showed both an age and radiation effect. After high single doses of neutrons or gamma rays, a significant age- and radiation-related deficiency in host defense mechanisms was detected by a shorter mean survival time following challenge with transplantable leukemia cells. Comparison of dose-response curves for life shortening after irradiation with fission-spectrum neutrons or high energy silicon particles indicated high initial slopes for both radiation qualities at low doses, but for higher doses of silicon, the effect per Gy decreased to a value similar to that for gamma rays. The two component life-shortening curve for silicon particles has implications for the potential efficacy of radioprotectants. Recent studies on protection against early and late effects by aminothiols, prostaglandins, and other compounds are discussed.     

Use of Airborne Monopulse Radar as a Low Approach Aid

The potential of airborne radar to provide pictorial displays as an aid to low approach has stimulated invention of several aircraft approach systems. Early developments are reviewed briefly, and an experiment in producing and flight testing a two-dimensional, range and azimuth, pictorial radar display is described. The monopulse radar equipment and a monopulse display improvement (MDI) technique used in the flight test to enhance the B-scope display are also described in some detail. Representative radar scope photographs are used to illustrate the display available in the aircraft.     

Coronal radio-sounding detection of a CME during the 1997 Galileo solar conjunction

Frequency fluctuations of the Galileo S-band radio signal were recorded nearly continuously during the spacecraft’s solar conjunction from December 1996 to February 1997. A strong propagating disturbance, most probably associated with a coronal mass ejection (CME), was detected on 7 February when the radio ray path proximate point was on the west solar limb at about 54 solar radii from the Sun. The CME passage through the line of sight is characterized by a significant increase in the fluctuation intensity of the recorded frequency and by an increase in the plasma speed from about 234 km s⁻¹ up to about 755 km s⁻¹. These velocity estimates are obtained from a correlation analysis of frequency fluctuations recorded simultaneously at two widely-separated ground stations. The density turbulence power spectrum is found to steepen behind the CME front. The Galileo radio-sounding data are compared with SOHO/LASCO observations of the CME in the corona and with WIND spacecraft data near the Earth’s orbit.     

On the fundamental acoustic mode in variable area,low Mach number nozzles

We consider the propagation of sound in nozzles of substantially varying cross-section, taking into account reflections from the tapering walls and non-uniform convection by the axially accelerated or decelerated mean flow. Exact solutions of the acoustic equations are obtained for the simplest case of the fundamental longitudinal mode in quasi-one-dimensional, low Mach number nozzle flow. The effects of non-uniform mean flow on sound are demonstrated by comparing horns with nozzles, and 15 properties (stated in italics and labelled P1, P2 ... P15 in the text) are proved and discussed, viz. concerning (1) relations between acoustic pressure and velocity; (2) equipartition or biasing of kinetic and compression energies; (3) conservation or evolution of wave action; (4) existence of elementary or special solutions and (5) cut-off frequencies, and amplitude and phase laws. We conclude with a simple formula for the approximate calculation of the acoustic fields; the formula can be made more accurate by using a correction factor for amplitude and phase, which is plotted against area ratio for propagation upstream or downstream in diffusers and convergent nozzles.     

Comets and life.

Some of the chemical species which have been detected in comets include H2O, HCN, CH3CN, CO, CO2, NH3, CS, C2 and C3. All of these have also been detected in the interstellar medium, indicating a probable relationship between interstellar dust and gas clouds and comets. Laboratory experiments carried out with different mixtures of these molecules give rise to the formation of the biochemical compounds which are necessary for life, such as amino acids, purines, pyrimidines, monosaccharides, etc. However, in spite of suggestions to the contrary, the presence of life in comets is unlikely. On the other hand, the capture of cometary matter by the primitive Earth is considered essential for the development of life on this planet. The amount of cometary carbon-containing matter captured by the Earth, as calculated by different authors, is several times larger than the total amount of organic matter present in the biosphere (10(18)g). The major classes of reactions which were probably involved in the formation of key biochemical compounds are discussed. Our tentative conclusions are that: 1) comets played a predominant role in the emergence of life on our planet, and 2) they are the cosmic connection with extraterrestrial life.     

Connection between the discrete auroral structures drifting equatorward during the substorm expansion phase and the energetic particle injections at the geostationary orbit

The formation of an auroral bulge with a bright dynamical arc at its polar boundary is one of the main manifestations of the magnetospheric substorm expansion phase at the ionospheric level. At the same time, the region of discrete aurora broadens not only polewards but equatorwards as well. The discrete forms of auroras moving equatorwards form a dynamical equatorial boundary of the auroral bulge shifting together with them. The paper presents a spatial-time comparison of the drifting discrete auroras to the injection of energetic particles at the geostationary orbit. It is shown that bursts in the fluxes of energetic particles at the LANL geostationary satellites located in the same sector of MLT correspond to the majority of drifting discrete auroral structures observed by the all-sky camera. In the cases when the bursts in the fluxes are absent, the minimum latitude reached by the auroral structures at the equatorward drift is higher than the ionospheric projection of the geostationary orbit. A possible relation of the drifting discrete auroras to the plasma stream jets in the plasma sheet is discussed.     

Cell inactivation, repair and mutation induction in bacteria after heavy ion exposure: results from experiments at accelerators and in space.

To understand the mechanisms of accelerated heavy ions on biological matter, the responses of spores of B. subtilis to this structured high LET radiation was investigated applying two different approaches. 1) By the use of the Biostack concept, the inactivation probability as a function of radial distance to single particles' trajectory (i.e. impact parameter) was determined in space experiments as well as at accelerators using low fluences of heavy ions. It was found that spores can survive even a central hit and that the effective range of inactivation extends far beyond impact parameters where inactivation by delta-ray dose would be effective. Concerning the space experiment, the inactivation cross section exceeds those from comparable accelerator experiments by roughly a factor of 20. 2) From fluence effect curves, cross sections for inactivation and mutation induction, and the efficiency of repair processes were determined. They are influenced by the ions characteristics in a complex manner. According to dependence on LET, at least 3 LET ranges can be differentiated: A low LET range (app. < 200 keV/micrometers), where cross sections for inactivation and mutation induction follow a common curve for different ions and where repair processes are effective; an intermediate LET range of the so-called saturation cross section with negligible mutagenic and repair efficiency; and a high LET range (>1000 keV/micrometers) where the biological endpoints are majorly dependent on atomic mass and energy of the ion under consideration.