Neutral buoyancy and sleep-deprived serum factors alter expression of cytokines regulating osteogenesis

We examined expression of genes associated with cytokine production, and genes implicated in regulating bone metabolism, in bone stromal and osteoblast cells incubated under standard ground conditions and under conditions of neutral buoyancy, and in the presence/absence of serum from normal or sleep-deprived mice. We observed a clear interaction between these two conditions (exposure to neutral buoyancy and serum stimulation) in promoting enhanced osteoclastogenesis. Both conditions independently altered expression of a number of cytokines implicated in the regulation of bone metabolism. However, using stromal cells from IL-1 and TNFx cytokine(r) KO mice, we concluded that the increased bone loss under microgravity conditions was not primarily cytokine mediated.     

Ground based ISS payload microgravity disturbance assessments

In order to verify that the International Space Station (ISS) payload facility racks do not disturb the microgravity environment of neighboring facility racks and that the facility science operations are not compromised, a testing and analytical verification process must be followed. Currently no facility racks have taken this process from start to finish. The authors are participants in implementing this process for the NASA Glenn Research Center (GRC) Fluids and Combustion Facility (FCF). To address the testing part of the verification process, the Microgravity Emissions Laboratory (MEL) was developed at GRC. The MEL is a 6 degree of freedom inertial measurement system capable of characterizing inertial response forces (emissions) of components, sub-rack payloads, or rack-level payloads down to 10(-7) g's. The inertial force output data, generated from the steady state or transient operations of the test articles, are utilized in analytical simulations to predict the on-orbit vibratory environment at specific science or rack interface locations. Once the facility payload rack and disturbers are properly modeled an assessment can be made as to whether required microgravity levels are achieved. The modeling is utilized to develop microgravity predictions which lead to the development of microgravity sensitive ISS experiment operations once on-orbit. The on-orbit measurements will be verified by use of the NASA GRC Space Acceleration Measurement System (SAMS). The major topics to be addressed in this paper are: (1) Microgravity Requirements, (2) Microgravity Disturbers, (3) MEL Testing, (4) Disturbance Control, (5) Microgravity Control Process, and (6) On-Orbit Predictions and Verification.     

Social desirability bias in personality testing: implications for astronaut selection

The assessment of personality is recognized by space agencies as an approach to identify candidates likely to perform optimally during spaceflights. In the use of personality scales for selection, the impact of social desirability (SD) has been cited as a concern. Study 1 addressed the impact of SD on responses to the Personality Characteristic Inventory(PCI) and NEO-FFI. This was achieved by contrasting scores from active astronauts (N=65) with scores of successful astronaut applicants (N=63), and between pilots applicants (N=1271) and pilot research subjects (N=120). Secondly, personality scores were correlated with scores on the Marlow Crown Social Desirability Scale among applicants to managerial positions (N=120). The results indicated that SD inflated scores on PCI scales assessing negative interpersonal characteristics, and impacted on four of five scales in NEO-FFI. Still, the effect sizes were small or moderate. Study 2 addressed performance implications of SD during an assessment of males applying to work as rescue personnel operations in the North Sea (N=22). The results showed that SD correlated negatively with cognitive test performance, and positively with discrepancy in performance ratings between self and two observers. In conclusion, caution is needed in interpreting personality scores in applicant populations. SD maybe a negative predictor for performance under stress.     

Spherical oscillation patterns

Spherical harmonics are an integral part of the study of stellar pulsations. To gain an understanding of how the star is affected by non-radial pulsations, the radial part of the oscillation is plotted, with an assumed sinusoidal time variation. The amplitude of the motion is arbitrarily set at 20% of the radius.     

Enhanced Power Generation of GSS4PS by Optical Solar Reflectors

A novel arrangement is proposed to enhance the power generation capabilities of a gravitationally stabilized solid-state-satellite solar-power station (GSS4PS) spherical solar collector. The unilluminated portion of a GSS4PS is illuminated by employing optical solar reflectors. The different mechanisms required for implementation of this arrangement are already space proven. The detailed study of this arrangement made by the authors reveals that practical realization of this concept will enhance the power generation capability of the GSS4PS and simultaneously reduce the weight per unit power and cost per unit power in GSS4PS spherical solar collectors.     

The August 1972 solar-terrestrial events: Interplanetary magnetic field observations

A review is presented of the interplanetary magnetic field observations acquired in early August 1972 when four solar flares erupted in McMath Plage region 11976. Measurements of the interplanetary field were obtained by Earth satellites, HEOS-2 and Explorer 41, and by Pioneers 9 and 10 which, by good fortune, were radially aligned and only 45° east of the Earth-Sun direction. In response to the four flares, four interplanetary shocks were seen at Earth and at Pioneer 9, which was then at a heliocentric distance of 0.78 AU. However, at Pioneer 10, which was 2.2 AU from the Sun, only two forward shocks and one reverse shock were seen. The available magnetic field data acquired in the vicinity of the shocks are presented. Efforts to identify corresponding shocks at the several locations and to deduce their velocities of propagation between 0.8 and 2.2 AU are reviewed. The early studies were based on average velocities between the Sun and Pioneer 9, the Sun and Earth and the Sun and Pioneer 10. A large deceleration of the shocks between the Sun and 0.8 AU as well as between 0.8 and 2.2 AU was inferred. More recently the local velocities of the shocks at Pioneers 9 and 10 have become available. A comparison of these velocities shows little, if any, deceleration between 0.8 and 2.2 AU and implies that most or all of the deceleration actually occurred nearer the Sun. Evidence is also presented that shows a significant departure of the flare-generated shock fronts from spherical symmetry.     

Research on Biolab, a multi-user facility for APM

A study carried out by a team of seven scientists appointed by ESA resulted in the design of a biological laboratory "Biolab" for Columbus APM. The basis for the study were four pre-Phase A studies performed by industry on the assumption that 15 racks would be available to biology and biotechnology in the APM. Due to the constraints newly imposed by the Columbus project, only five racks are now allocated. The tasks of the Biolab scientific team were: (i) to define the scientific objectives of biological research in Columbus; (ii) to review the requirements of the industrial studies; and (iii) to design a multi-purpose facility compatible with the present constraints and satisfying the requirements of the biological investigations considered in the four studies. The Biolab team was able to define a facility capable of accommodating in five racks the following biological objects: small plants (up to 40 cm), insects like drosophila, frog eggs, single cells from animals, bacteria, slime molds and protozoa, as well as human physiology, but restricted to general diagnostic needs. The Biolab facility includes instruments and devices providing the capacity of holding and/or growing the organisms as well as to perform basic experimentation and a minimum essential diagnostic inflight. Within the growth unit the growth chambers/incubators are exchangeable, permitting the use of growth chambers of different sizes. The temperature will be adjustable to the requirements of the objects under investigation, i.e. either 20 or 37 degrees C. Thus a considerable level of flexibility will permit to investigate a broad spectrum of living systems.     

Solar physics assessment of future high-resolution observations in the Grazing-Incidence domain

The project for a Grazing Incidence Solar Telescope (GRIST) offers, for the first time, the combinations of high spatial (1) and spectral resolution in the extreme-ultraviolet wavelength range. The 3-dimensional electron density and temperature structure of the transition region and corona will be determined. The dynamics of the structures which make up the corona will be studied. GRIST can be expected to provide definitive improvement in the understanding of the coronal heating problem.Proceedings of the Conference Solar Physics from Space, held at the Swiss Federal Institute of Technology Zurich (ETHZ), 11–14 November 1980.     

Flow of material at the Chromosphere-Corona transition zone of the Sun

Early models of the Chromosphere-Corona transition zone of the Sun considered it to be a static plane-parallel region. From these it became clear that the layer was extremely thin and had an important role in the conduction of energy from the Corona. More recent observations show mass motions of order 10 km s^-1, which means that heating and cooling of the moving plasma has an important affect on the energy balance, while transient effects producing far higher velocities are also common. Studies of plasma motion through the zone are clearly relevant to the initial heating of material which enters the solar wind.Paper presented at the IX-th Lindau Workshop The Source Region of the Solar Wind.     

Space radiation dosimetry with active detections for the scientific program of the second Bulgarian cosmonaut on board the Mir space station.

A dosimetry-radiometry system has been developed at the Space Research Institute of the Bulgarian Academy of Science to measure the fluxes and dose rates on the flight of the second Bulgarian cosmonaut. The dosimetry system is designed for monitoring the different space radiations, such as solar cosmic rays, galactic cosmic rays and trapped particles in the earth radiation belts. The system consists of a battery operated small size detector unit and a "read-write" and telemetry microcomputer unit. The sensitivity of the instrument (3.67 x 10(-8) rad/pulse) permits high resolution measurements of the flux and dose rate along the track of the Mir space station. We report our initial results for the period of the flight between the 7th and 17th June 1988.