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51.
Gorczynski RM Gorczynski CP Gorczynski LY Hu J Lu J Manuel J Lee L 《Acta Astronautica》2005,56(9-12):890-899
We examined expression of genes associated with cytokine production, and genes implicated in regulating bone metabolism, in bone stromal and osteoblast cells incubated under standard ground conditions and under conditions of neutral buoyancy, and in the presence/absence of serum from normal or sleep-deprived mice. We observed a clear interaction between these two conditions (exposure to neutral buoyancy and serum stimulation) in promoting enhanced osteoclastogenesis. Both conditions independently altered expression of a number of cytokines implicated in the regulation of bone metabolism. However, using stromal cells from IL-1 and TNFx cytokine(r) KO mice, we concluded that the increased bone loss under microgravity conditions was not primarily cytokine mediated. 相似文献
52.
F K Gmünder M Kiess G Sonnenfeld J Lee A Cogoli 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1992,12(1):55-61
We investigated the effect of substratum adhesiveness on stimulated lymphocyte blastogenesis by reducing and blocking cell adhesion with poly (2-hydroxyethyl methacrylate) (poly-HEMA) in a simple on-ground system. Cells grown on medium-thick and thick poly-HEMA films were rounded in shape and displayed no signs of spreading. By contrast, on tissue culture plastic and very thin poly-HEMA films, they showed clear signs of spreading. The mitogenic response of lymphocytes grown on thick poly-HEMA films was reduced by up to 68% of the control (tissue culture plastic). Interferon-gamma production was near zero when the cells were grown on the least adhesive substratum. On uncoated plastic, activated lymphocytes subjected to high gravity (20g) exhibited an increased proliferation rate (40%) compared with 1g. By contrast, on poly-HEMA, high gravity did not improve lymphocyte responsiveness. These results show that activated lymphocytes need to anchor and spread prior to achieving an optimal proliferation response. We conclude that decreased lymphocyte adhesion could contribute to the depressed in vitro lymphocyte responsiveness found in the microgravity conditions of space flight. 相似文献
53.
An input filter is frequently employed between a switching regulator and its power source. However, its presence often results in degradation of dynamic performances and stability. The detrimental interaction is between an input filter and a switching regulator and is a function of the input filter parameters and also of the supply voltage. An earlier paper presented an analysis and design procedure aimed at developing a feed-forward loop to cancel this undesirable interaction. The feed-forward design is extended here to encompass a scheme that automatically accounts for changes in the supply voltage; the result is an adaptive compensation that tracks the input voltage variations. Experimental results are presented that confirm the adaptive nature of the design. 相似文献
54.
55.
Plaschke Ferdinand Hietala Heli Archer Martin Blanco-Cano Xóchitl Kajdič Primož Karlsson Tomas Lee Sun Hee Omidi Nojan Palmroth Minna Roytershteyn Vadim Schmid Daniel Sergeev Victor Sibeck David 《Space Science Reviews》2018,214(5):1-66
Space Science Reviews - Particles are accelerated to very high, non-thermal energies in solar and space plasma environments. While energy spectra of accelerated electrons often exhibit a power law,... 相似文献
56.
Chae Kyung Sim Huynh Anh Nguyen Le Soojong Pak Hye-In Lee Wonseok Kang Moo-Young Chun Ueejeong Jeong In-Soo Yuk Kang-Min Kim Chan Park Michael D. Pavel Daniel T. Jaffe 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2014
We present a Python-based data reduction pipeline package (PLP) for the Immersion GRating INfrared Spectrograph (IGRINS), an instrument that covers the complete H- and K-bands in one exposure with a spectral resolving power of 40,000. The reduction steps carried out by the PLP include flat-fielding, background removal, order extraction, distortion correction, wavelength calibration, and telluric correction using spectra of A type standard stars. As the spectrograph has no moving parts, the PLP automatically reduces the data using predefined functions for the processes of order extraction, distortion correction, and wavelength calibration. Before the telluric correction of the target spectra, the intrinsic hydrogen absorption features of the standard A star are removed with a Gaussian fitting algorithm. The final result is the flux of the target as a function of wavelength. Users can customize the predefined functions for the extraction of the spectrum from the echellogram and adjust the parameters for the fitting functions for the spectra of celestial objects, using “fine-tuning” options, as necessary. Presently, the PLP produces the best results for point-source targets. 相似文献
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58.
Eun-Jung Choi Jae-Cheol Yoon Byoung-Sun Lee Sang-Young Park Kyu-Hong Choi 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2010
Spaceborne GPS receivers are used for real-time navigation by most low Earth orbit (LEO) satellites. In general, the position and velocity accuracy of GPS navigation solutions without a dynamic filter are 25 m (1σ) and 0.5 m/s (1σ), respectively. However, GPS navigation solutions, which consist of position, velocity, and GPS receiver clock bias, have many abnormal excursions from the normal error range for space operation. These excursions lessen the accuracy of attitude control and onboard time synchronization. In this research, a new onboard orbit determination algorithm designed with the unscented Kalman filter (UKF) was developed to improve the performance. Because the UKF is able to obtain the posterior mean and covariance accurately by using the second-order Taylor series expansion through the sampled sigma points that are propagated by using the true nonlinear system, its performance can be better than that of the extended Kalman filter (EKF), which uses the linearized state transition matrix to predict the covariance. The dynamic models for orbit propagation applied perturbations due to the 40 × 40 geo-potential, the gravity of the Sun and Moon, solar radiation pressure, and atmospheric drag. The 7(8)th-order Runge–Kutta numerical integration was applied for orbit propagation. Two types of observations, navigation solutions and C/A code pseudorange, can be used at the user’s discretion. The performances of the onboard orbit determination were verified using real GPS data of the CHAMP and KOMPSAT-2 satellites. The results of the orbit determination were compared with the precision orbit ephemeris (POE) of the CHAMP and KOMPSAT-2 satellites. 相似文献
59.
航空航天复合材料应用的最新进展 总被引:3,自引:0,他引:3
文章介绍了先进复合材料的最新进展情况,内容包括用于最新复合材料体系的各种增强纤维、树脂基体,及复合材料结构设计的一些新概念。重点介绍了低成本和高效的制造技术。复合材料重要结构件的制造技术在不断改进,制造出的部件不仅精度和强度更高,而且更显成本效益。文章还介绍了航空航天领域一些新研发的复合材料结构件。 相似文献
60.
Forced vibration analysis including a vortex lattice prediction given an external aerodynamic force is conducted in this paper based on a standing wave formulation. The starting point of the standing wave formulation is a set of blade disk normal modes that incorporate all forms of the blade, disk, and shroud elastic coupling. The Küssner gust function was used in a few previous investigations of forced vibration based on the standing wave formulation. However, it was found to be valid only for low engine-order excitation. Therefore, a two-dimensional unsteady vortex lattice method is employed in this paper to predict the gust excitation up to higher engine-order excitation. Thus, the present unsteady vortex lattice analytical model is capable of capturing compressibility and higher engine-order excitation. It features advantages in terms of its computational time and level of accuracy. The effects of mistuning a cascaded blade are also examined in the present aeroelastic analysis to determine the possible advantages obtained by doing this. Numerical results for the mistuned bladed disk are presented regarding its forced response characteristics. In a low engine-order excitation condition, it is shown that similar predictions are obtained between the present and earlier analyses. The maximum discrepancy in the blade amplitude is 70% for a single-blade mistuned rotor and 62.6% for an alternately mistuned rotor, in the worst case, compared to a completely tuned rotor. Single-peak frequencies are presented and analyzed in the higher engine-order excitation levels. 相似文献