On the levels of enzymatic substrate specificity: implications for the early evolution of metabolic pathways.

The most frequently invoked explanation for the origin of metabolic pathways is the retrograde evolution hypothesis. In contrast, according to the so-called "patchwork" theory, metabolism evolved by the recruitment of relatively inefficient small enzymes of broad specificity that could react with a wide range of chemically related substrates. In this paper it is argued that both sequence comparisons and experimental results on enzyme substrate specificity support the patchwork assembly theory. The available evidence supports previous suggestions that gene duplication events followed by a gradual neoDarwinian accumulation of mutations and other minute genetic changes lead to the narrowing and modification of enzyme function in at least some primordial metabolic pathways.     

Psychosocial effects of adjustment in Antarctica: lessons for long-duration spaceflight

This paper examines the utility of remote, isolated Antarctic research stations as analogs for long-duration spaceflights from the perspective of psychosocial processes of adaptation and adjustment. Certain features of the physical and man-made environments found in Antarctica are similar to those that will be encountered in outer space. In both settings, men and women are likely to experience a number of physiological and psychological changes in response to the extreme environmental conditions and the prolonged isolation and confinement. Biomedical research in Antarctica provides an opportunity to study the causes of these changes and to develop strategies for reducing the risks to health and well-being before they pose a serious threat to crew safety and mission success. A number of lessons for long-duration spaceflight are examined, including screening and selection of personnel; training programs designed to facilitate individual adjustment and group adaptation and minimize group conflict; identification of optimal leadership characteristics for small, isolated groups; an understanding of social dynamics and group "microcultures" necessary for the organization and management of small but heterogeneous groups; organization of work activities; facility design; and support infrastructure.     

Lunar habitat concept employing the space shuttle external tank

The space shuttle external tank, which consists of a liquid oxygen tank, an intertank structure, and a liquid hydrogen tank, is an expendable structure used for approximately 8.5 min during each launch. A concept for outfitting the liquid oxygen tank-intertank unit for a 12-person lunar habitat is described. The concept utilizes existing structures and openings for both man and equipment access without compromising the structural integrity of the tank. Living quarters, instrumentation, environmental control and life support, thermal control, and propulsion systems are installed at Space Station Freedom. The unmanned habitat is then transported to low lunar orbit and autonomously soft landed on the lunar surface. Design studies indicate that this concept is feasible by the year 2000 with concurrent development of a space transfer vehicle and manned cargo lander for crew changeover and resupply.     

Radar Cross Section of Ships

A laboratory method to determine the magnitude and position of radar reflection sources on complex targets is described. In addition the method provides a way to measure the modification of the radar cross section (RCS) due to multipath. The method has application in modeling RCS for radar and electronic countermeasure (ECM) system performance analysis and in the study of the extent to which the signature of the target could be altered. The equipment described, termed MACROSCOPE, was developed for RCS studies by the U.S. Army and is described in limited distribution bution literature. The application to marine targets is new with this paper, as is the technique of measuring the RCS of parts of the target and analytically combining them to represent the whole. An illustration of the need for this type of laboratory equipment was illustrated by the extensive search for full scale data which could be compared to scale model data to validate the technique.     

Study of the variability of blazars gamma-ray emission

The γ-ray emission of blazar jets shows a pronounced variability and this feature provides limits to the size and to the speed of the emitting region. We study the γ-ray variability of bright blazars using data from the first 18 months of activity of the Large Area Telescope on the Fermi Gamma-Ray Space Telescope. From the daily light-curves of the blazars characterized by a remarkable activity, we firstly determine the minimum variability time-scale, giving an upper limit for the size of the emitting region of the sources, assumed to be spheroidal blobs in relativistic motion. These regions must be smaller than ∼10⁻³ parsec. Another interesting time-scale is the duration of the outbursts. We conclude that they cannot correspond to radiation produced by a single blob moving relativistically along the jet, but they are either the signature of emission from a standing shock extracting energy from a modulated jet, or the superposition of a number of flares occurring on a shorter time-scale. We also derive lower limits on the bulk Lorentz factor needed to make the emitting region transparent for gamma-rays interacting through photon–photon collisions.     

Two magnetars: SGR 1627–41 and 1E 1547–5408

We describe the results obtained with Target of Opportunity observations of the galactic sources SGR 1627–41 and 1E 1547–5408. These two transients show several similarities supporting the interpretation of Anomalous X-ray Pulsars and Soft Gamma-ray Repeaters as a single class of strongly magnetized neutron stars.     

Study of GNSS-measured ionospheric total electron content variations generated by powerful HF-heating

The purpose of this work is to report the experimental evidences for the influence of perturbations in the electron density in the dayside mid-latitude ionosphere, that are caused by high-frequency heating of the F2 layer, on the GNSS signals. The experiments were carried out at the Sura heater (Radio Physical Research Institute, N. Novgorod). During the sessions of ionospheric heating with different time modulations of the radiated power the rays linking the navigational satellites with the ground receiver intersected the heated region. Variations in the total electron content (TEC) were studied; these variations are proportional to the reduced phases of navigational signals. It is shown that with the square-wave modulation of the radiated power (with periods of 1, 6, 10 and 15 min), perturbations with periods of the main modulation of heating and its harmonics appear in the spectrum of TEC variations. Examples are presented of identification of the heating-induced variations in TEC, including determination of the amplitudes and time characteristics of these variations.     

Application of high-order accurate methods to solve the computational gas dynamics and aeroacoustics problems

The application of the low dissipative high-order accurate scheme for numerical solution of the Euler and Navier-Stokes equations in the two-dimensional statement is considered. The scheme of calculating space derivatives is the seven-point central-difference approximation of the fourth order with the coefficients optimized to reduce the dispersion errors. The optimized six-step Runge-Kutta method is used for evaluating the time derivatives. By means of filtration, spurious pulsations are suppressed and shocks are processed. The results of verifying the calculation scheme realized on the stationary problem of flow around the model turbine blades are presented.