Harnessing functional food strategies for the health challenges of space travel—Fermented soy for astronaut nutrition

Astronauts face numerous health challenges during long-duration space missions, including diminished immunity, bone loss and increased risk of radiation-induced carcinogenesis. Changes in the intestinal flora of astronauts may contribute to these problems. Soy-based fermented food products could provide a nutritional strategy to help alleviate these challenges by incorporating beneficial lactic acid bacteria, while reaping the benefits of soy isoflavones. We carried out strain selection for the development of soy ferments, selecting strains of lactic acid bacteria showing the most effective growth and fermentation ability in soy milk (Streptococcus thermophilus ST5, Bifidobacterium longum R0175 and Lactobacillus helveticus R0052). Immunomodulatory bioactivity of selected ferments was assessed using an in vitro challenge system with human intestinal epithelial and macrophage cell lines, and selected ferments show the ability to down-regulate production of the pro-inflammatory cytokine interleukin-8 following challenge with tumour necrosis factor-alpha. The impact of fermentation on vitamin B1 and B6 levels and on isoflavone biotransformation to agluconic forms was also assessed, with strain variation-dependent biotransformation ability detected. Overall this suggests that probiotic bacteria can be successfully utilized to develop soy-based fermented products targeted against health problems associated with long-term space travel.     

Production of neutrons from interactions of GCR-like particles

In order to help assess the risk to astronauts due to the long-term exposure to the natural radiation environment in space, an understanding of how the primary radiation field is changed when passing through shielding and tissue materials must be obtained. One important aspect of the change in the primary radiation field after passing through shielding materials is the production of secondary particles from the breakup of the primary. Neutrons are an important component of the secondary particle field due to their relatively high biological weighting factors, and due to their relative abundance, especially behind thick shielding scenarios. Because of the complexity of the problem, the estimation of the risk from exposure to the secondary neutron field must be handled using calculational techniques. However, those calculations will need an extensive set of neutron cross section and thicktarget neutron yield data in order to make an accurate assessment of the risk. In this paper we briefly survey the existing neutron-production data sets that are applicable to the space radiation transport problem, and we point out how neutron production from protons is different than neutron production from heavy ions. We also make comparisons of one the heavy-ion data sets with Boltzmann-Uehling-Uhlenbeck (BUU) calculations.     

The Mawrth Vallis region of Mars: A potential landing site for the Mars Science Laboratory (MSL) mission

The primary objective of NASA's Mars Science Laboratory (MSL) mission, which will launch in 2011, is to characterize the habitability of a site on Mars through detailed analyses of the composition and geological context of surface materials. Within the framework of established mission goals, we have evaluated the value of a possible landing site in the Mawrth Vallis region of Mars that is targeted directly on some of the most geologically and astrobiologically enticing materials in the Solar System. The area around Mawrth Vallis contains a vast (>1?×?10? km2) deposit of phyllosilicate-rich, ancient, layered rocks. A thick (>150?m) stratigraphic section that exhibits spectral evidence for nontronite, montmorillonite, amorphous silica, kaolinite, saponite, other smectite clay minerals, ferrous mica, and sulfate minerals indicates a rich geological history that may have included multiple aqueous environments. Because phyllosilicates are strong indicators of ancient aqueous activity, and the preservation potential of biosignatures within sedimentary clay deposits is high, martian phyllosilicate deposits are desirable astrobiological targets. The proposed MSL landing site at Mawrth Vallis is located directly on the largest and most phyllosilicate-rich deposit on Mars and is therefore an excellent place to explore for evidence of life or habitability.     

The failure of marginal detonations in expanding channels

Critical conditions for detonation failure due to tube expansion have been observed in marginal detonations propagating in a in. (6.35 × 76.2 mm) channel. In these experiments, a well established marginal detonation propagating in the narrow channel entered a test section in which one of the narrow walls was inclined to the central axis at positive angles which ranged from 10° to 45°. Experiments were performed at pressures ranging from 60 to 200 torr (8 to 26.7 kPa) in stoichiometric hydrogen-oxygen mixtures diluted with 20, 50 and 70% argon. Smoke track records obtained on the surface which is the major dimension of the tube, were used to determine failure, incipient failure or self-sustenance of the entering wave.Because of the narrow tube used in the studies the incident waves were marginal in that their velocity was below the expected CJ (Chapman-Jouguet) value, their transverse wave spacing was larger than one would see in a large tube, and the transverse waves were of greater strength than in an ordinary detonation. All of these indicators of marginal behavior became progressively more pronounced as the pressure dropped from 200 torr (26.7 kPa) to the limit pressure of approximately 58 torr (7.73 kPa).The most interesting result of this experimental investigation is that the theoretical analyses predicted that simple one-dimensional opening of the tube should not show a pressure dependence to failure, while the experiments showed a definite decrease in the opening angle required for failure as initial pressure decreased. This behavior is related to the marginality of the incident waves, which is observed to increase smoothly with decreased pressure. It is postulated that detonation failure in the hydrogen-oxygen system occurs when the shock velocity at the end of the cell drops to about 0.60 of the CJ value due either to marginal behavior or to an expansion of the cross section of the tube.