Rhythmic biological systems under microgravity conditions.

Rhythmic phenomena in biology cover a wide frequency spectrum. In Space, the rhythms will encounter microgravity conditions which can, therefore, be a valuable tool for their understanding. A review and discussion of important effects of gravity/absence of gravity on biological systems will be given. Convection will be emphasized as a mechanism which is drastically reduced in Space. Microgravity might also affect the coupling between individual oscillators in a multi-oscillatory system. The environmental interference with rhythms will be discussed with a simple feedback as a starting point. Model simulations will be presented and clinostat and microgravity-conditions will be discussed in a specific case, viz. the gravitropical system of plants which can show sustained oscillations.     

Fast Maximnurm Likelihood Joint Estimation of Frequency and Frequency Rate

A fast maximum likelihood algorithm is presented that jointly estimates the frequency and frequency rate of a sinusoid corrupted by additive Gaussian white noise. It consists of a coarse search and a fine search. First the two-dimensional frequency-frequency rate plane is subdivided into parallelograms whose size depends on the region of convergence of Newton's method used in maximizing the log-likelihood function (LLF). The size of the parallelogram is explicitly computed and is optimal for the method used. The coarse search consists of maximizing the LLF over the vertices of the parallelograms. Then starting at the vertex where the LLF attained its maximum, a two-dimensional Newton's method to find the absolute maximum of the LLF is implemented. This last step consists of the fine search. The rate of convergence of Newton's method is cubic, and is extremely fast. Furthermore Newton's method will converge after two iterations when the starting point used in the method lies within 75 percent of the distances defined by the parallelogram of convergence whose center coincides with the true values of frequency and frequency rate. In this case, the root mean square error (RMSEs) for frequency and frequency rate are practically equal to the Cramer-Rao bound at all signal-to-noise ratio (SNR)?15 dB. The frequency-frequency rate ambiguity function is shown to be even and its periodicities are extracted.     

DNA-lesion and cell death by alpha-particles and nitrogen ions.

When the natural logarithm of the surviving fraction is plotted against the dose of radiation, curves with shoulders at relatively high survival levels are obtained after gamma-rays. The curves were practically linear in case of HMV-I and HA-1 cells irradiated by charged particle beams. These cells were derived from human malignant melanoma and Chinese hamster cells, respectively. The amount of DNA single strand breaks (ssb) by gamma-rays or nitrogen-ions (LET=530KeV/micrometers) in HMV-I cells increases linearly with increment in dose, when the ssb is detected using the alkaline elution technique. There is no close relationship between the dose-response curve of the ssb and the dose-survival curves after gamma-rays or N-ions. The amount of DNA double strand breaks (dsb) by gamma-rays increases quadratically with increment of dose, in both HMV-I cells and HA-1 cells, when the dsb is detected using the neutral elution technique. The survival fraction for HA-1 cells is slightly higher than that for HMV-I cells, at the same dose, and the amount of dsb for HA-1 cells is considerably greater than that for HMV-I cells. These results suggest that the radiosensitivities to gamma-rays in different cell lines do not correspond to the number of DNA strand breaks. The amount of both non-repairable ssb and dsb also increases quadratically with increment of dose for gamma-rays and almost linearly with increment of dose for N-ions and alpha-particles (LET=36keV/micrometers for HA-1 cells and LET=77keV/micrometers for HMV-I cells). The dose-response curves for non-repairable dsb in case of these radiations seemed to mirror image the dose-survival curves for these radiations, in both cell lines. The number of non-repairable DNA strand breaks in the two cell lines, at the same level of survival was much the same. These results show the close relationship between the induction of non-repairable DNA strand breaks and cell killing.     

The quantification of wound healing as a method to assess late radiation damage in primate skin exposed to high-energy protons.

In an experiment examining the effects of space radiations on primates, different groups of rhesus monkeys (Macaca mulatta) were exposed to single whole-body doses of 32- or 55-MeV protons. Survivors of those exposures, together with age-matched controls, have been monitored continuously since 1964 and 1965. Late effects of nominal proton doses ranging from 2-6 Gray have been measured in vitro using skin fibroblasts from the animals. A logical extension of that study is reported here, and it involves observations of wound healing after 3-mm diameter dermal punches were removed from the ears (pinnae) of control and irradiated monkeys. Tendencies in the reduction of competence to repair cutaneous wounds have been revealed by the initial examinations of animals that received doses greater than 2 Gy more than 2 decades earlier. These trends indicate that this method of assessing radiation damage to skin exposed to high-energy radiations warrants further study.     

Integrated CIS VLF/Omega receiver design

The design of an integrated Russian-VLF/Omega receiver implemented on a TMS320C30-microprocessor-based SPECTRUM plug-in board installed in a PC-compatible portable computer is presented. The system also requires an external antenna, pre-amp, and frequency reference. The SPECTRUM board digitizes the RF signal to 16 b and then digitally mixes with the sines and cosines of the three Russian frequencies plus 10.2, 11-1/3, and 13.6 kHz. The mixer outputs are low-pass filtered, and the comb filters are implemented for the respective epochs. The computer accesses and processes the comb filter outputs, calculating and logging signal phase and amplitude. The design allows for easy future expansion to include unique and VLF communication frequencies     

Energetic particle measurements onboard Spectr-R with MEP-2

The energetic particle experiment MEP-2 onboard the Spectr-R high apogee satellite is briefly described. The instrument measures fluxes and spectra of electrons (30 keV–350 keV) and ions (30 keV–3.2MeV), using two pairs of silicon detectors. The example of first observations upstream from the bow shock illustrates its successful operation in space. Unique observations of ～30 s strong fluctuations of energetic ions with energies up to two hundred keV are discussed.     

First stage identification of syntactic elements in an extra-terrestrial signal

By investigating the generic attributes of a representative set of terrestrial languages at varying levels of abstraction, it is our endeavour to try and isolate elements of the signal universe, which are computationally tractable for its detection and structural decipherment. Ultimately, our aim is to contribute in some way to the understanding of what ‘languageness’ actually is. This paper describes algorithms and software developed to characterise and detect generic intelligent language-like features in an input signal, using natural language learning techniques: looking for characteristic statistical “language-signatures” in test corpora. As a first step towards such species-independent language-detection, we present a suite of programs to analyse digital representations of a range of data, and use the results to extrapolate whether or not there are language-like structures which distinguish this data from other sources, such as music, images, and white noise.     

A new US approach to human spaceflight?

In 2010 the administration of President Barack Obama proposed a dramatically new approach to future US human spaceflight. That new strategy was immediately controversial. This article traces the origins of the new spaceflight strategy and the continuing political debate with respect to its acceptance.     

RPC-MIP: the Mutual Impedance Probe of the Rosetta Plasma Consortium

The main objective of the Mutual Impedance Probe (MIP), part of the Rosetta Plasma Consortium (RPC), is to measure the electron density and temperature of Comet 67P/Churyumov-Gerasimenko’s coma, in particular inside the contact surface. Furthermore, MIP will determine the bulk velocity of the ionised outflowing atmosphere, define the spectral distribution of natural plasma waves, and monitor dust and gas activities around the nucleus. The MIP instrumentation consists of an electronics board for signal processing in the 7 kHz to 3.5 MHz range and a sensor unit of two receiving and two transmitting electrodes mounted on a 1-m long bar. In addition, the Langmuir probe of the RPC/LAP instrument that is at about 4 m from the MIP sensor can be used as a transmitter (in place of the MIP ones) and MIP as a receiver in order to have access to the density and temperature of plasmas at higher Debye lengths than those for which the MIP is originally designed.