应用绿色半导体量子点进行乳腺癌原位成像

乳腺癌是癌症中引起妇女死亡的首要因素。本文采用绿色量子点作为荧光显色材料，建立了一种用于早期乳腺癌诊断的原位成像技术。利用生物素标记的抗HER2／neu抗体与乳腺癌细胞表面表达的HER2结合的特点，然后用偶联绿色量子点的链霉亲和素作为荧光检测标记物，与HER2抗原抗体复合物中的生物素发生特异结合，检测出乳腺癌细胞的存在。结果表明，在荧光显微镜下用绿色量子点原位显色的乳腺癌细胞，相对有机染料组显色亮度增强，故检测灵敏度有所提高。     

Design concepts for the first 40 km a key step for the space elevator

The Marine Node for the Space Elevator Infrastructure is the base for all activities to load and unload the cargo and climbers. As the basic design of the space elevator power system is solar power only, the first 40 km is hazardous to operations and demands enclosed packaging of fragile tether climbers. A significant question is: how do we place a full-up tether climber, driven by solar power, above the atmosphere? Two approaches, starting at the Marine Node, allow the tether climber to initiate the climb with solar energy above the atmosphere. The third viable approach is to provide a platform at altitude for initiation of tether climb. These approaches would enable solar power to be the source of energy for climbing. The three approaches are:     

The first SETI observations with the Allen telescope array

The Search for ExtraTerrestrial Intelligence (SETI) finally has its own full-time telescope. The Allen telescope array (ATA) in Northern California was dedicated on October 11, 2007. This array, which will eventually be composed of 350 small radio antennas, each 6.1 m in diameter, is being built as a partnership between the SETI Institute and the University of California Radio Astronomy Laboratory. Last October, Paul G. Allen (who provided the funds for the technology development and the first phase of array construction) pushed a silver button and all 42 antennas of the current ATA-42 slewed to point in the direction of the distant galaxy M81. Specialized electronic backend detectors attached to the ATA began making a radio map of that galaxy and simultaneously began SETI observations of HIP48573, a G5V star near M81 on the sky and a distance of 264 light years from Earth. The Allen telescope array will greatly improve the speed of conducting SETI searches over the next few decades, and it will allow a suite of different search strategies to be undertaken. This paper summarizes some of the earliest SETI observations from the array, and describes the search strategies currently being planned.     

FIBERSIM(R)在无人机复合材料部件开发中的优点

FiberSIM能辅助无人机复合材料结构在更低的成本下取得更轻的重量,同时能标准化和自动化完成开发过程。高空无人机的机身约占起飞总重的三分之一。任何对机身的减重都直接转化成增加传感器或有效载荷、飞行持续时间。因此制造者专注于采用工业定义的工程过程来设计     

Proposal for ionospheric tomography technique using a new HF radio source

Measurements of the line integral of the electron density along satellite-to-ground ray paths (i.e. TEC) using differential phase or Doppler of two coherent VHF/UHF signals transmitted from NNSS or GPS satellite networks have been used in the ionospheric tomography for mapping large-scale ionospheric images over region of interest. In this paper, we present theoretical studies of using a new signal source HF frequency in tomographic imaging. The initial phase problem inherent in the phase measurement can be eliminated by measuring Faraday rotations. Relative rotation on two adjacent HF frequencies is used to solve the ambiguity problem. A second-order approximation of the Faraday rotation incorporated with ray-tracing technique improves the reconstruction degradation due to ionospheric refractions. CASSIOPE is a multi-purpose small satellite that receives HF signals from ground radar facilities and it is scheduled for launch in early 2008. Simulations have demonstrated the potential applications of the ionospheric tomography in CASSIOPE/e-POP satellite experiment.     

The Urey instrument: an advanced in situ organic and oxidant detector for Mars exploration

The Urey organic and oxidant detector consists of a suite of instruments designed to search for several classes of organic molecules in the martian regolith and ascertain whether these compounds were produced by biotic or abiotic processes using chirality measurements. These experiments will also determine the chemical stability of organic molecules within the host regolith based on the presence and chemical reactivity of surface and atmospheric oxidants. Urey has been selected for the Pasteur payload on the European Space Agency's (ESA's) upcoming 2013 ExoMars rover mission. The diverse and effective capabilities of Urey make it an integral part of the payload and will help to achieve a large portion of the mission's primary scientific objective: "to search for signs of past and present life on Mars." This instrument is named in honor of Harold Urey for his seminal contributions to the fields of cosmochemistry and the origin of life.     

Impact craters as biospheric microenvironments, Lawn Hill Structure, Northern Australia

Impact craters on Mars act as traps for eolian sediment and in the past may have provided suitable microenvironments that could have supported and preserved a stressed biosphere. If this is so, terrestrial impact structures such as the 18-km-diameter Lawn Hill Structure, in northern Australia, may prove useful as martian analogs. We sampled outcrop and drill core from the carbonate fill of the Lawn Hill Structure and recorded its gamma-log signature. Facies data along with whole rock geochemistry and stable isotope signatures show that the crater fill is an outlier of the Georgina Basin and was formed by impact at, or shortly before, approximately 509-506 million years ago. Subsequently, it was rapidly engulfed by the Middle Cambrian marine transgression, which filled it with shallow marine carbonates and evaporites. The crater formed a protected but restricted microenvironment in which sediments four times the thickness of the nearby basinal succession accumulated. Similar structures, common on the martian surface, may well have acted as biospheric refuges as the planet's water resources declined. Low-pH aqueous environments on Earth similar to those on Mars, while extreme, support diverse ecologies. The architecture of the eolian crater fill would have been defined by long-term ground water cycles resulting from intermittent precipitation in an extremely arid climate. Nutrient recycling, critical to a closed lacustrine sub-ice biosphere, could be provided by eolian transport onto the frozen water surface.     

Changes in operational procedures to improve spaceflight experiments in plant biology in the European Modular Cultivation System

The microgravity environment aboard orbiting spacecraft has provided a unique laboratory to explore topics in basic plant biology as well as applied research on the use of plants in bioregenerative life support systems. Our group has utilized the European Modular Cultivation System (EMCS) aboard the International Space Station (ISS) to study plant growth, development, tropisms, and gene expression in a series of spaceflight experiments. The most current project performed on the ISS was termed Seedling Growth-1 (SG-1) which builds on the previous TROPI (for tropisms) experiments performed in 2006 and 2010. Major technical and operational changes in SG-1 (launched in March 2013) compared to the TROPI experiments include: (1) improvements in lighting conditions within the EMCS to optimize the environment for phototropism studies, (2) the use of infrared illumination to provide high-quality images of the seedlings, (3) modifications in procedures used in flight to improve the focus and overall quality of the images, and (4) changes in the atmospheric conditions in the EMCS incubator. In SG-1, a novel red-light-based phototropism in roots and hypocotyls of seedlings that was noted in TROPI was confirmed and now can be more precisely characterized based on the improvements in procedures. The lessons learned from sequential experiments in the TROPI hardware provide insights to other researchers developing space experiments in plant biology.     

Application of neural networks to South African GPS TEC modelling

The propagation of radio signals in the Earth’s atmosphere is dominantly affected by the ionosphere due to its dispersive nature. Global Positioning System (GPS) data provides relevant information that leads to the derivation of total electron content (TEC) which can be considered as the ionosphere’s measure of ionisation. This paper presents part of a feasibility study for the development of a Neural Network (NN) based model for the prediction of South African GPS derived TEC. The South African GPS receiver network is operated and maintained by the Chief Directorate Surveys and Mapping (CDSM) in Cape Town, South Africa. Vertical total electron content (VTEC) was calculated for four GPS receiver stations using the Adjusted Spherical Harmonic (ASHA) model. Factors that influence TEC were then identified and used to derive input parameters for the NN. The well established factors used are seasonal variation, diurnal variation, solar activity and magnetic activity. Comparison of diurnal predicted TEC values from both the NN model and the International Reference Ionosphere (IRI-2001) with GPS TEC revealed that the IRI provides more accurate predictions than the NN model during the spring equinoxes. However, on average the NN model predicts GPS TEC more accurately than the IRI model over the GPS locations considered within South Africa.