Estimation of risk based on multiple events in radiation carcinogenesis of rat skin.

In the multistage theory of carcinogenesis, cells progress to cancer through a series of discrete, irreversible, heritable genetic alterations or mutations. However data on radiation-induced cancer incidence in rat skin suggests that some part of an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to the following radiations: 1. an electron beam (LET=0.34 keV/um, 2. a neon ion beam (LET=25 keV/um and 3. an argon ion beam (LET=125 keV/um. The latter 2 beams were generated by the Bevalac at the Lawrence Berkeley Laboratory, Berkeley, CA. About 6.0 cm2 of skin was irradiated per rat. The rats were observed every 6 weeks for at least 78 weeks and tumors were scored at first occurrence. Several histological types of cancer, including squamous and basal cell carcinomas, were induced. The cancer yield versus radiation dose was fitted by the quadratic equation (Y(D)=CLD+BD2), and the parameters C and B were estimated for each type of radiation. Analysis of the DNA from the electron-induced carcinomas indicated that K-ras and/or c-myc oncogenes were activated in all tumors tested, although only a small proportion of neon-induced tumors showed similar activation. In situ hybridization indicated that the cancers contain subpopulations of cells with differing amounts of c-myc and H-ras amplification. The results are consistent with the idea that ionizing radiation produces carcinogenically relevant lesions via 2 repairable events at low LET and via a non-repairable, linked event pathway at high LET; either pathway may advance the cell by 1 stage in the multistage model. The model, if validated, permits the direct calculation of cancer risk in rat skin in a way that can be subjected to experimental testing.     

Measurement of middle atmospheric ozone density profile by rocket-borne radiometer onboard KSR-II

KSR-II, a two-stage sounding rocket of KARI was launched successfully at the Korean Peninsula on June 11, 1998. The apogee of the rocket was 137 km. For the ozone measurement, 8-channel UV and visible radiometers were onboard the rocket. The rocket measured an in situ stratospheric and mesospheric ozone density profile over Korea during its ascending phase using the radiometer and transmitted the data to ground station in real time. The maximum ozone density occurs near 25 km. Retrieved profile has a random error (1σ) of approximately 15% for altitude below 20km, 7% between 20-50 km and 10% greater than 50 km. The retrieved data were compared with Dobson spectrophotometer, ozonesonde, and HALOE onboard the UARS. Our results are in reasonable agreements with others.     

“自准”赝像及识别

置平面镜于凸透镜后,则凸透镜前焦平面上的物成像于该物平面上,即“自准”成像.满足其它条件也能成像于物平面.分析不同条件下像的形成及其特点,并给出识别自准成像的判据.     

某型客车噪声源的测试与研究

本文通过对某型客车的噪声测试分析，识别出该型客车的主要噪声源，为进一步采取有效的降噪措施提供了必要依据。     

基于容差分配的直升机多约束运动系统的应用与研究

本文以某民用直升机动力舱多约束运动系统的容差分配设计为例,阐述和分析了多约束运动系统容差基准的选取、分配以及设计补偿等。可以为多约束运动系统设计提供方法和参考。     

基于环形切割器的串联战斗部隔爆结构的优选

硬质聚氨酯具有刚度小、材质松散、易于吸收爆炸能量的特点,是一种很好的隔爆材料。为了设计环形切割器与后级随进战斗部之间的隔爆装置,利用LS-DYNA分别进行了圆柱型、圆锥型、球缺型3种聚氨酯隔爆体的数值模拟研究。通过研究得出结论:球缺型结构既节省材料,又可以更有效地降低前级产生的冲击波对后级战斗部的影响。该结论有助于带环形切割器串联战斗部的隔爆设计。     

民用飞机不同商载配置对机身着陆载荷的影响分析

重量分布和重心位置是影响起落架和机体地面载荷的重要因素,其中商载是影响全机重心、惯量的最活跃因素。飞机实际运营中,有无穷多种商载分布及装载方案。为了确保机身载荷分析时,不遗漏严重设计情况,同时能大大减少载荷人员的工作量,本文对不同商载配置下的机身着陆载荷进行了研究分析,分析结果表明最大商载情况将构成机身垂直剪力和垂直弯矩的严重情况。因此,在进行机身载荷分析时,必须考虑最大商载情况,而最大燃油情况可以不必考虑。这一结论为今后有针对性的开展民机机身载荷分析提供了数据支持。     

对K8飞机外贸出口工作的几点思考

简要论述了K8飞机外贸出口所处的内、外部环境,在此基础上进行SWOT分析,并据此提出该飞机外贸出口工作中应采取的几项措施。     

俄罗斯卫星制造产业概览(下)

二、拉沃奇金科研生产联合体拉沃奇金科研生产联合体(NPO LA)是俄罗斯另一家大型航天公司。该公司在发展俄航天技术,特别是在行星际空间探索中起着重要的作用,同时还从事科学卫星和地球观测卫星的研制。2.1发展简况拉沃奇金联合体建于1937年4月,当时主要是设计制造军用飞机。S.     

CMH模型中部分参数对磁滞回线形状影响的研究

研究了Complete Moving Hysteresis模型计算公式中部分参数对磁滞回线形状的影响 ,发现饱和磁化强度Ms 和移动参数α对回线形状的影响并不显著 ,但参量γ的影响却是明显的 ,随着γ值的增加 ,回线的斜率增加 ,突变性增强