基于CFD技术的鼻腔输药的流动特性研究

鼻腔输药作为一种新颖的输药方式,具有方便可靠的特点,不仅可以适用于局部而且适用于全身用药,已经受到广泛的重视。但由于人类的呼吸道复杂的立体结构使得鼻腔输药成为生物医药研究的一个长期的挑战。利用CFD(计算流体动力学,Computational Fluid Dynamics)技术对鼻腔输药的流动特性进行研究,对一个基于真实的人类鼻腔解剖的3D模型的输药的流动过程进行了分析,着重研究了不同的药物颗粒的流动和沉淀特性。利用CFD的商用软件FLUENT在层流情况下对不同的密度、直径和流动速率的药物颗粒在鼻腔中流动进行了数值模拟,并对计算结果进行了比较分析。CFD研究的结果为鼻腔输药这种新颖的药物输送方式的优化设计提供了依据。     

Probing the era of galaxy formation via TeV gamma ray absorption by the near infrared extragalactic background

We present models of the extragalactic background light (EBL) based on several scenarios of galaxy formation and evolution. We have treated galaxy formation with the Press-Schecter approximation for both cold dark matter (CDM) and cold+hot dark matter (CHDM) models, representing a moderate (z _f 3) and a late (z _f 1) era of galaxy formation respectively. Galaxy evolution has been treated by considering a variety of stellar types, different initial mass functions and star formation histories, and with an accounting of dust absorption and emission. We find that the dominant factor influencing the EBL is the epoch of galaxy formation. A recently proposed method for observing the EBL utilizing the absorption of 0.1 to 10 TeV gamma-rays from active galactic nuclei (AGN) is shown to be capable of discriminating between different galaxy formation epochs. The one AGN viewed in TeV light, Mrk 421, does show some evidence for a cutoff above 3 TeV; based on the EBL models presented here, we suggest that this is due to extinction in the source. The large absorption predicted at energies > 200 GeV for sources at z > 0.5 indicates that observations of TeV gamma-ray bursts (GRB) would constrain or eliminate models in which the GRB sources lie at cosmological distances.Now at University of Chicago, Dept. of Astronomy & Astrophysics.     

Discrete-time observability and estimability analysis for bearings-only target motion analysis

Observability in the context of bearings-only tracking (BOT) is still the subject of important literature. Different from previous approaches, where continuous-time analysis was considered, our approach relies on discrete-time analysis. It is then shown that this allows us to use directly and efficiently the simple formalisms of linear algebra. Using the direct approach, observability analysis is essentially reduced to basic considerations about subspace dimensions. Even if this approach is conceptually quite direct, it becomes more and more complex as the source-encounter scenario complexity increases. For complex scenarios, the dual approach may present some advantages essentially due to the direct use of multilinear algebra. New results about BOT observability for maneuvering sources are thus obtained. Observability analysis is then extended to unknown instants of source velocity changes. Even if observability analysis provides thorough insights about the algebraic structure of the BOT problem, the optimization of the observer maneuvers is essentially a control problem. Basic algebraic considerations prove that a relevant cost functional for this control problem is the determinant of the Fisher information matrix (FIM). So, a large part of this work is devoted to the analysis of this cost functional. Using multilinear algebra, general approximations of this functional are given. In order to involve only directly estimable parameters, the source bearing-rates are examined. Using these approximations, a general framework for optimizing the observer trajectory is derived which allow us to approximate the optimal sequence of controls. It is worth stressing that our approach does not require the knowledge of the source trajectory parameters and is still valid for a maneuvering source.     

Phase Space Density Analysis of Energy Transport in the Earth’s Magnetotail

Two energetic events in the Earth’s magnetotail detected by Geotail are examined with detailed analysis of three-dimensional velocity phase space density. It is found that the occurrence of multiple ion components is high during these dynamic episodes. Different populations evolve independently of each other, suggesting particles from multiple activity sites contributing to the observed phase space density. The transport properties with consideration of multiple components are evaluated, with the result showing significant differences from those based on a single fluid approach. This comparison indicates that precise evaluation of the energy and magnetic flux transport of energetic events in the magnetotail requires resolving individual populations in the phase space density.     

Instability and unsteadiness of aircraft wake vortices

This paper presents a review of theoretical and experimental results on stability and other unsteady properties of aircraft wakes. The basic mechanisms responsible for the propagation and the amplification of perturbation along vortices, namely the Kelvin waves and the cooperative instabilities, are first detailed. These two generic unsteady mechanisms are described by considering asymptotic linear stability analysis of model flows such as vortex filaments or Lamb–Oseen vortices. Extension of the linear analysis to more representative flows, using a biglobal stability approach, is also described. Experimental results obtained using LDV, hot wire and PIV in wind tunnels are presented and they are commented upon the light of theory.     

PHD filters of higher order in target number

The multitarget recursive Bayes nonlinear filter is the theoretically optimal approach to multisensor-multitarget detection, tracking, and identification. For applications in which this filter is appropriate, it is likely to be tractable for only a small number of targets. In earlier papers we derived closed-form equations for an approximation of this filter based on propagation of a first-order multitarget moment called the probability hypothesis density (PHD). In a recent paper, Erdinc, Willett, and Bar-Shalom argued for the need for a PHD-type filter which remains first-order in the states of individual targets, but which is higher-order in target number. In this paper we show that this is indeed possible. We derive a closed-form cardinalized PHD (CPHD) filter, which propagates not only the PHD but also the entire probability distribution on target number.     

A New Mathematical Formulation for Strapdown Inertial Navigation

A differential equation is developed for the orientation vector relating the body frame to a chosen reference frame. The time derivative of this vector is the sum of the inertially measurable angular velocity vector and of the inertially nonmeasurable noncommutativity rate vector. It is precisely this noncommutativity rate vector that causes the computational problems when numerically integrating the direction cosine matrix. The orientation vector formulation allows the noncommutativity contribution to be isolated and, therefore, treated separately and advantageously. An orientation vector mechanization is presented for a strap down inertial system. Further, an example is given of the applica tion of this formulation to a typical rigid body rotation problem.     

Specification and Performance of Passive Sonar Spectral Estimators

The application of existing estimation theory to the problem of specification and performance of passive sonar spectral estimators is considered. The classification function is addressed, so that the signal is assumed to be present, and so that the energy arrival angle is known. The spatial filter considered is a line array of M equally spaced omnidirectional hydrophones. Signal and ambient noise are both zero-mean, wide-sense, stationary Gaussian random processes that differ in their spatial correlation across the face of the array. The signal is a plane wave that can be made totally spacially corrected between array elements by inserting delays between sensors to invert the signal propagation delay. The noise correlation is a function of frequency, bandwidth, element separation, and the relative time delay between sensors. Under these assumptions, the Cramer-Rao lower bound is derived for the class of unbiased estimates of signal power in a narrow frequency band at the hydrophone in the presence of correlated ambient noise of known power. The bound is examined numerically, resulting in a threshold phenomenon with M that constitutes a new design consideration. In addition, there is a striking insensitivity to realistic values of ambient noise correlation, and there are ranges in signal-to-noise ratio for which one gains more by increasing M than by increasing the bandwidth-time product. Specific processors, including a new unbiased estimator when noise power is unknown, are developed.     

Radar Performance with Multipath Using the Complex Angle

The complex angle (CA) method for resolving a low angle target from its multipath signal is evaluated in the presence of system noise. It is shown that standard deviation improvements of around 3-to-1 can be achieved at a 20-dB signal-to-noise power ratio relative to a normal monopulse system without the CA. It is also shown that the CA method is unbiased, giving bias improvements of as much as 100 times relative to normal monopulse. Evaluation of the assumptions in the technique shows very little sensitivity to knowledge of the reflecting surface's conductivity or dielectric constant. However, the method is somewhat sensitive to knowledge of surface roughness.