Parathyroid hormone-related protein is a gravisensor in lung and bone cell biology.

Parathyroid Hormone-related Protein (PTHrP) has been shown to be essential for the development and homeostatic regulation of lung and bone. Since both lung and bone structure and function are affected by microgravity, we hypothesized that 0 x g down-regulates PTHrP signaling. To test this hypothesis, we suspended lung and bone cells in the simulated microgravity environment of a Rotating Wall Vessel Bioreactor, which simulates microgravity, for up to 72 hours. During the first 8 hours of exposure to simulated 0 x g, PTHrP expression fell precipitously, decreasing by 80-90%; during the subsequent 64 hours, PTHrP expression remained at this newly established level of expression. PTHrP production decreased from 12 pg/ml/hour to 1 pg/ml/hour in culture medium from microgravity-exposed cells. The cells were then recultured at unit gravity for 24 hours, and PTHrP expression and production returned to normal levels. Based on these findings, we have obtained bones from rats flown in space for 2 weeks (Mission STS-58, SL-2). Analysis of PTHrP expression by femurs and tibias from these animals (n=5) revealed that PTHrP expression was 60% lower than in bones from control ground-based rats. Interestingly, there were no differences in PTHrP expression by parietal bone from space-exposed versus ground-based animals, indicating that the effect of weightlessness on PTHrP expression is due to the unweighting of weight-bearing bones. This finding is consistent with other studies of microgravity-induced osteoporosis. The loss of the PTHrP signaling mechanism may be corrected using chemical agents that up-regulate this pathway. In conclusion, PTHrP represents a stretch-sensitive paracrine signaling mechanism that may sense gravity.     

Water and Volatiles in the Outer Solar System

Space Science Reviews - Space exploration and ground-based observations have provided outstanding evidence of the diversity and the complexity of the outer solar system. This work presents our...     

Sources of Interference in Spatial Long-Term Memory Retrieval

Three experiments are reported that used an interference paradigm to test the extent to which perceptual orientation to a task environment interfered with retrieval from long-term spatial memory. Visual and spatial sources of interference were tested. The findings were consistent with a spatial locus of interference and showed that orientation to the task environment disrupted the accessibility of relative direction under two retrieval conditions: when the imagined viewpoint was 180 degrees misaligned with the actual viewpoint and when the actual body location was anterior to the imagined body location. While the former finding replicates previous reports of interference in perspective-taking tasks, the latter finding is new and difficult for current models of spatial long-term memory retrieval to explain. More research is needed to articulate further the constraints that perceptual orientation to the task environment place on spatial retrieval and their implications for models of spatial memory.     

Acousto-optic spectrum analyzer techniques for monitoring CW

The issues associated with processing the outputs of an integrating acoustooptical spectrum analyzer (AOSA) to detect and identify the frequency and power of continuous wave (CW) signals are considered. The performance of the optimum detection strategy is presented, along with the Cramer-Rao bound on the performance of estimators of the frequency, and the performance of a simple peak-based frequency estimator. The performance of the maximum likelihood (ML) estimator of the power level is also presented. The results provide the behavior of the system as a function of the product of the aperture time and photodetector spacing amongst other parameters     

A three-dimensional plasma and energetic particle investigation for the wind spacecraft

This instrument is designed to make measurements of the full three-dimensional distribution of suprathermal electrons and ions from solar wind plasma to low energy cosmic rays, with high sensitivity, wide dynamic range, good energy and angular resolution, and high time resolution. The primary scientific goals are to explore the suprathermal particle population between the solar wind and low energy cosmic rays, to study particle accleration and transport and wave-particle interactions, and to monitor particle input to and output from the Earth's magnetosphere.Three arrays, each consisting of a pair of double-ended semi-conductor telescopes each with two or three closely sandwiched passivated ion implanted silicon detectors, measure electrons and ions above 20 keV. One side of each telescope is covered with a thin foil which absorbs ions below 400 keV, while on the other side the incoming <400 keV electrons are swept away by a magnet so electrons and ions are cleanly separated. Higher energy electrons (up to 1 MeV) and ions (up to 11 MeV) are identified by the two double-ended telescopes which have a third detector. The telescopes provide energy resolution of E/E0.3 and angular resolution of 22.5°×36°, and full 4 steradian coverage in one spin (3 s).Top-hat symmetrical spherical section electrostatic analyzers with microchannel plate detectors are used to measure ions and electrons from 3 eV to 30 keV. All these analyzers have either 180° or 360° fields of view in a plane, E/E0.2, and angular resolution varying from 5.6° (near the ecliptic) to 22.5°. Full 4 steradian coverage can be obtained in one-half or one spin. A large and a small geometric factor analyzer measure ions over the wide flux range from quiet-time suprathermal levels to intense solar wind fluxes. Similarly two analyzers are used to cover the wide range of electron fluxes. Moments of the electron and ion distributions are computed on board.In addition, a Fast Particle Correlator combines electron data from the high sensitivity electron analyzer with plasma wave data from the WAVE experiment (Bougeretet al., in this volume) to study wave-particle interactions on fast time scales. The large geometric factor electron analyzer has electrostatic deflectors to steer the field of view and follow the magnetic field to enhance the correlation measurements.     

"Signal" search for intelligence in the galactic nucleus with the array of the Lowlands

In August, 1981, the Westerbork Synthesis Radio Telescope was used for 4 h to search for narrowband pulsing radio beacons in the direction of the Galactic Center. By using both the spatial discrimination and temporal stability available to an interferometric measurement, weak intermittent signals can be detected even in the face of the strong, naturally caused radiation from this region. A radio beacon within our bandwidth, centered on the 21 cm neutral hydrogen line, would be recognizable if it had a repetition period between 40 sec and 1/2 h. The rms sensitivity to point sources was approximately 50 mJy/cycle, and the detection limit was 500 mJy/cycle. The limit degrades for pulse widths < 0.02s. No repetitive signals were found. For a swept, narrow-band radio beacon constrained to the Galactic Disk (beamwidth = 0.02 rad), our detection limit corresponds to a transmitter power of 10(11) MW at the Galactic Center.     

Preliminary results of Cytos 2 experiment.

Cytos 2 experiment, carried out during the French-Soviet manned flight (July 1982), has studied the antibiotics sensitivity of bacteria cultivated in vitro during the orbital flight. The results show an increase of the antibiotics resistance and a larger thickness of the cellular envelope for the inflight cells. The increase of antibiotics resistance can be related to a stimulating effect of space on the cell growth rate or to changes of the cellular envelope structure.     

Hermes vehicle

The presence of Europe in the future developments of spatial programs, which are foreseen, for the 1990s and further, needs the availability of vehicles, modules and all related technologies adapted to operational use of low earth orbit station.The manned HERMES vehicle shall be part of the in-orbit infrastructure realized either in the European context or in cooperation between Europe and the United States.The main mission for this vehicle will be to run a shuttle with the station that means transport and change of the crews, its safe return in abort condition and cargo transport of consumable and experimental equipment.Secondary missions could be servicing on automatic platform, making autonomous scientific experiments. Lastly, the vehicle, by means of its on-board propulsion capability, could be used to accomplish in-orbit tow and assembly missions.Studies which are undertaken now about the vehicle are devoted to the aerodynamic shape (research of a compromise between aerothermic and overall fitting), the system (functional architecture, ground and flight configuration); further works dealing with technology are presently on hand in the field of thermal protection, aerodynamics, power generation with a high massic yield.     

Order of magnitude analysis of convective effects in dendritic solidification

The different types of convective phenomena which may occur during the dendritic solidification of metallic alloys are discussed from an order of magnitude analysis. Bulk thermal convection and/or interdendritic solutal convection have to be considered according to the values of the experimental data. Scaling laws for the solute boundary layer resulting from bulk thermal convection have already been derived. It is shown here that the interdendritic flow depends on a solutal Grashof number Gr based on the horizontal density gradient and a characteristic length L_s which is of the order of the liquid channels width. For Gr < 1, which is generally verified in practical cases, the interdendritic flow velocity U_r is proportional to the Grashof number. This a priori law compares favorably with the results of horizontal solidification experiments where the mean interdendritic flow velocity has been estimated from the resulting measured macrosegregation. In these experiments, as well as for most horizontal dendritic solidifications of metallic alloys at 1 g, the ratio $\text{U}{}_{\mathrm{r}}\text{R}$ (R is the growth rate) is of order one. In order to cancel the interdendritic flow effects, this ratio has to be lowered by one order of magnitude. According to our analysis, this can be obtained by performing the experiments either at a slightly reduced g level (～10^?1 g), or at 1 g in a vertical stable configuration with a sufficiently low residual horizontal thermal gradient.