Differential GPS/inertial navigation approach/landing flight testresults

In November 1990, a differential GPS/inertial flight test was conducted to acquire a system performance database and demonstrate automatic landing using an integrated differential GPS/INS with barometric and radar altimeters. Flight test results obtained from postflight data analysis are presented. These results include characteristics of DGPS/inertial error, using a laser tracker as a reference. In addition, data are provided on the magnitude of the differential correlations and vertical channel performance with and without radar altimeter augmentation. Flight test results show one sigma DGPS/inertial horizontal errors of 9 ft and one sigma DGPS inertial vertical errors of 15 ft. Without selective availability effects, the differential corrections are less than 10 ft and are dominated by receiver unique errors over the time period of an approach. Therefore, the one sigma performance of the autonomous GPS (8-ft horizontal and 20-ft vertical) is very similar to the DGPS/inertial performance. Postprocessed results also demonstrate significant improvements in vertical channel performance when GPS/inertial is aided with radar altimeter along with a low-resolution terrain map     

DNA damage and repair in oncogenic transformation by heavy ion radiation.

Energetic heavy ions are present in galactic cosmic rays and solar particle events. One of the most important late effects in risk assessment is carcinogenesis. We have studied the carcinogenic effects of heavy ions at the cellular and molecular levels and have obtained quantitative data on dose-response curves and on the repair of oncogenic lesions for heavy particles with various charges and energies. Studies with repair inhibitors and restriction endonucleases indicated that for oncogenic transformation DNA is the primary target. Results from heavy ion experiments showed that the cross section increased with LET and reached a maximum value of about 0.02 micrometer2 at about 500 keV/micrometer. This limited size of cross section suggests that only a fraction of cellular genomic DNA is important in radiogenic transformation. Free radical scavengers, such as DMSO, do not give any effect on induction of oncogenic transformation by 600 MeV/u iron particles, suggesting most oncogenic damage induced by high-LET heavy ions is through direct action. Repair studies with stationary phase cells showed that the amount of reparable oncogenic lesions decreased with an increase of LET and that heavy ions with LET greater than 200 keV/micrometer produced only irreparable oncogenic damage. An enhancement effect for oncogenic transformation was observed in cells irradiated by low-dose-rate argon ions (400 MeV/u; 120 keV/micrometer). Chromosomal aberrations, such as translocation and deletion, but not sister chromatid exchange, are essential for heavy-ion-induced oncogenic transformation. The basic mechanism(s) of misrepair of DNA damage, which form oncogenic lesions, is unknown.     

The role of DNA repair on cell killing by charged particles.

It can be noted that it is not simple double strand breaks (dsb) but the non-reparable breaks that are associated with high biological effectiveness in the cell killing effect for high LET radiation. Here, we have examined the effectiveness of fast neutrons and low (initial energy = 12 MeV/u) or high (135 MeV/u) energy charged particles on cell death in 19 mammalian cell lines including radiosensitive mutants. Some of the radiosensitive lines were deficient in DNA dsb repair such as LX830, M10, V3, and L5178Y-S cells and showed lower values of relative biological effectiveness (RBE) for fast neutrons if compared with their parent cell lines. The other lines of human ataxia-telangiectasia fibroblasts, irs 1, irs 2, irs 3 and irs1SF cells, which were also radiosensitive but known as proficient in dsb repair, showed moderated RBEs. Dsb repair deficient mutants showed low RBE values for heavy ions. These experimental findings suggest that the DNA repair system does not play a major role against the attack of high linear energy transfer (LET) radiations. Therefore, we hypothesize that a main cause of cell death induced by high LET radiations is due to non-reparable dsb, which are produced at a higher rate compared to low LET radiations.     

Simulation experiments of the effect of space environment on bacteriophage and DNA thin films.

The main goal of PUR experiment (phage and uracil response) is to examine and quantify the effect of specific space conditions on nucleic acid models. To achieve this an improved method was elaborated for the preparation of DNA and bacteriophage thin films. The homogeneity of the films was controlled by UV spectroscopy and microscopy. To provide experimental evidence for the hypothesis that interplanetary transfer of the genetic material is possible, phage T7 and isolated T7 DNA thin films have been exposed to selected space conditions: intense UVC radiation (lambda=254 nm) and high vacuum (10(-4) Pa). The effects of DNA hydration, conformation and packing on UV radiation damage were examined. Characteristic changes in the absorption spectrum, in the electrophoretic pattern of DNA and the decrease of the amount of PCR products have been detected indicating the photodamage of isolated and intraphage DNA.     

Influence of long-term altered gravity on the swimming performance of developing cichlid fish: including results from the 2nd German Spacelab Mission D-2.

This study presents qualitative and quantitative data concerning gravity-dependent changes in the swimming behaviour of developing cichlid fish larvae (Oreochromis mossambicus) after a 9 resp. 10 days exposure to increased acceleration (centrifuge experiments), to reduced gravity (fast-rotating clinostat), changed accelerations (parabolic aircraft flights) and to near weightlessness (2nd German Spacelab Mission D-2). Changes of gravity initially cause disturbances of the swimming performance of the fish larvae. With prolonged stay in orbit a step by step normalisation of the swimming behaviour took place in the fish. After return to 1g earth conditions no somersaulting or looping could be detected concerning the fish, but still slow and disorientated movements as compared to controls occurred. The fish larvae adapted to earth gravity within 3-5 days. Fish seem to be in a distinct early developmental stages extreme sensitive and adaptable to altered gravity; However, elder fish either do not react or show compensatory behaviour e.g. escape reactions.     

Enzyme conversion of lignocellulosic plant materials for resource recovery in a Controlled Ecological Life Support System.

A large amount of inedible plant material composed primarily of the carbohydrate materials cellulose, hemicellulose, and lignin is generated as a result of plant growth in a Controlled Ecological Life-Support System (CELSS). Cellulose is a linear homopolymer of glucose, which when properly processed will yield glucose, a valuable sugar because it can be added directly to human diets. Hemicellulose is a heteropolymer of hexoses and pentoses that can be treated to give a sugar mixture that is potentially a valuable fermentable carbon source. Such fermentations yield desirable supplements to the edible products from hydroponically-grown plants such as rapeseed, soybean, cowpea, or rice. Lignin is a three-dimensionally branched aromatic polymer, composed of phenyl propane units, which is susceptible to bioconversion through the growth of the white rot fungus, Pluerotus ostreatus. Processing conditions, that include both a hot water pretreatment and fungal growth and that lead to the facile conversion of plant polysaccharides to glucose, are presented.     

James Webb Space Telescope: Project Overview

The James Webb Space Telescope (JWST) project at the NASA, Goddard Space Flight Center (GSFC) is responsible for the development, launch, flight, and science operations for the telescope. The project is in phase B with its launch scheduled for no earlier than June 2013. The project is a partnership among NASA, the European Space Agency (ESA), and the Canadian Space Agency (CSA). The JWST mission team is fully in place, including major ESA and CSA subcontractors. This provides an overview of the planned JWST science, current architecture focusing on the instrumentation, and mission status, including technology developments, and risks.     

Recent Breakthroughs in RF Photonics for Radar Systems

Radar systems require transmission of very high purity signals. Photonics is now mature enough to achieve analog transmission with very low noise, strong immunity, and wide-bandwidth even in harsh environments. We present our recent developments of optimized optical links dedicated to radar and multifunction systems     

Spiral evolution applied to legacy avionics systems

The US Department of Defense (DoD), through the Office of the Secretary of Defense (OSD), has determined that evolutionary acquisition is their strategy of choice for future software-intensive systems, and that the spiral development model (SDM) is the preferred method/process for software-intensive development life cycles. Electronic Systems Command (ESC) at Hanscom AFB, Massachusetts, has written a draft handbook on the use of Spiral Development for all future Command and Control (C2) systems, including reference to the DoD 5000 series and Air Force Program Directive 63-1, Acquisition System, which deploys this OSD mandate for future C2 systems. Barry Boehm's continued work on SDM which he conceived in the 1980s, is heavily biased toward development of new systems that are software-intensive, as noted in a workshop he gave at the Software Engineering Institute (SEI) in 2000.