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81.
Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation. 总被引:3,自引:0,他引:3
T K Hei Y L Zhao D Roy C Q Piao G Calaf E J Hall 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2001,27(2):411-419
Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process. 相似文献
82.
D J Grdina B A Garnes B Nagy 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1992,12(2-3):257-263
Two thiophosphoroate compounds WR-2721 and WR-151327 were assessed for their ability to modify the deleterious effects (life shortening and carcinogenesis) of fission-spectrum neutrons (kerma-weighted mean energy of 0.85 MeV) or gamma rays on B6CF1 hybrid mice. Male and female mice, 200 of each sex per experimental group, were irradiated individually at 110 days of age. Radioprotectors (400 mg/kg of WR-2721 or 580 mg/kg of WR-151327) were administered intraperitoneally 30 min prior to irradiation. Neutron doses were 10 cGy or 40 cGy and gamma ray doses were 206 cGy or 417 cGy. Animals were housed five to a cage; cage locations in the holding rooms were randomized by computer. Animals were checked daily and all deceased animals were necropsied. WR-2721 afforded protection against both neutron- and gamma-ray-induced carcinogenesis and subsequent life shortening. Cumulative survival curves for unirradiated mice of either sex were unaffectecd by protectors. WR-2721 protected irradiated groups against life shortening by approximately 10 cGy of neutrons or 100 cGy of gamma rays. WR-151327 was as effective as WR-2721 against neutron irradiation. 相似文献
83.
A flat panel multifunction display (MFD) that offers the size and reliability benefits of liquid crystal display technology while achieving near-CRT display quality is presented. Display generation algorithms that provide exceptional display quality are being implemented in custom VLSI components to minimize MFD size. A high-performance processor converts user-specified display lists to graphics commands used by these components, resulting in high-speed updates of two-dimensional and three-dimensional images. The MFD uses the MIL-STD-1553B data bus for compatibility with virtually all avionics systems. The MFD can generate displays directly from display lists received from the MIL-STD-1553B bus. Complex formats can be stored in the MFD and displayed using parameters from the data bus. The MFD also accepts direct video input and performs special processing on this input to enhance image quality 相似文献
84.
Aiming at a 1-cm Orbit for Low Earth Orbiters: Reduced-Dynamic and Kinematic Precise Orbit Determination 总被引:1,自引:0,他引:1
The computation of high-accuracy orbits is a prerequisite for the success of Low Earth Orbiter (LEO) missions such as CHAMP,
GRACE and GOCE. The mission objectives of these satellites cannot be reached without computing orbits with an accuracy at
the few cm level. Such a level of accuracy might be achieved with the techniques of reduced-dynamic and kinematic precise
orbit determination (POD) assuming continuous Satellite-to-Satellite Tracking (SST) by the Global Positioning System (GPS).
Both techniques have reached a high level of maturity and have been successfully applied to missions in the past, for example
to TOPEX/POSEIDON (T/P), leading to (sub-)decimeter orbit accuracy. New LEO gravity missions are (to be) equipped with advanced
GPS receivers promising to provide very high quality SST observations thereby opening the possibility for computing cm-level
accuracy orbits. The computation of orbits at this accuracy level does not only require high-quality GPS receivers, but also
advanced and demanding observation preprocessing and correction algorithms. Moreover, sophisticated parameter estimation schemes
need to be adapted and extended to allow the computation of such orbits. Finally, reliable methods need to be employed for
assessing the orbit quality and providing feedback to the different processing steps in the orbit computation process.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
85.
Lithium ion battery technology is being introduced into power supplies used by our armed forces for a variety of applications. In many cases, the same cells and design parameters that support commercial battery packs are being used in military battery packs. This approach is expected to result in a major decrease in the total life cycle cost of the equipment these batteries support. On June 13, 1991, NAVSEA issued INST9310.1B1, which states that all lithium battery powered equipment must undergo safety evaluation and approval prior to fleet use. This safety program governs a process whereby approvals are issued for lithium batteries to be used in specific equipment on ground facilities, surface combatants, air combatants, and/or submarines. The Naval Ordnance Safety and Security Activity (NOSSA) manages the program. The chief technical advisors are Code 644 at NSWC Carderock Division and Code 609A at NSWC Crane Division. This paper describes three battery designs that incorporate lithium ion technology, and the results of battery safety tests conducted in accordance with navy requirements. 相似文献
86.
Stratton D.A. Stengel R.F. 《IEEE transactions on aerospace and electronic systems》1993,29(4):1185-1194
Severe low-altitude wind shear is a threat to aviation safety. Newly developed airborne sensors measure the radial component of wind along a line directly in front of an aircraft. The authors use optimal estimation theory to define a detection algorithm to warn of hazardous wind shear from these sensors. To achieve robustness, a wind shear detection algorithm must distinguish threatening wind shear from less hazardous gustiness, despite variations in wind shear structure. Statistical analysis methods to refine wind shear detection algorithm robustness are presented. Computational methods predict the ability to warn of severe wind shear and avoid false warning. Comparative capability of the detection algorithm as a function of its design parameters is determined, identifying designs that provide robust detection of severe wind shear 相似文献
87.
Intersecting spheres are useful in the design of pressure vessels for weight limited situations as in the case of space or ocean applications. This paper treats the general problem of N intersecting spheres demonstrating that mass reduction can be achieved in relation to the single sphere that encloses the same internal volume. It is shown that this reduction approaches asymptotically the value of 39.5%. 相似文献
88.
Role of BIT in support system maintenance and availability 总被引:1,自引:0,他引:1
The role of built in test (BIT) in electronic systems has grown in prominence with the advances in system complexity and concern over maintenance lifecycle costs of large systems. In an environment where standards drive system designs (and provide an avenue for focused advancement in technology), standards for BIT are very much in an evolutionary state. The reasons for advancing the effectiveness of BIT include reduced support overhead, greater, confidence in operation, and increased system availability. The cost of supporting military electronic systems (avionics, communications, and weapons systems) has driven much of the development in BIT technology. But what about the systems that support these end items that contain test and measurement instrumentation - such as automatic test equipment (ATE), simulators and avionics development suites? There has also been a beneficial effect on the maintenance and availability of these systems due to the infusion of BIT into their component assemblies. But the effect has been much more sporadic and fragmented. This paper looks at the state of BIT in test and measurement instruments, explain its affect on system readiness, and present ideas on how to improve BIT technologies and standards. This will not provide definitive answers to BIT development questions, since the factors that affect it are specific to the instrument itself. The topics covered in this paper are: definitions of built-in test, instrument BIT history, importance of BIT fault coverage and isolation in support systems, overview of BIT development process issues that limit the effectiveness of BIT Standards related to instrument BIT, making BIT more effective in support system maintenance and availability and conclusions. 相似文献
89.
R D Govorun I V Koshlan N A Koshlan E A Krasavin N L Shmakova 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2002,30(4):885-890
The induction of HPRT-mutations and survival of Chinese hamster cells (line B11ii-FAF28, clone 431) were studied after irradiation by 4He and 12C-ions of various LET (20-360 keV/micrometers), produced by the U-200 heavy ion accelerator. The RBE increases with LET up to the maximum at 100-200 keV/micrometers and then decreases. Cytogenetic analysis was performed on the HPRT-mutant subclones selected from unirradiated Chinese hamster V-79 cells and from HPRT-mutant subclones that arose after exposure to gamma-rays, 1 GeV protons and 14N-ions (LET-77 keV/micrometers), produced by the synchrophasotron and the U-400M heavy ion accelerator. Slow growing mutant subclones were observed. The cytogenetic properties of individual clones were highly heterogeneous and chromosome instability was observed in both spontaneous and radiation-induced mutants. Chromosome instability was highest among spontaneous mutants and decreased with increasing LET. 相似文献
90.
The force exerted by the solar radiation, though very small in magnitude, produces significant effects, especially in the case of high altitude satellites. The solar radiation pressure represents one freely available environmental force that may be put to use for various purposes. This may lead to enhancement of the life of the satellite since it consumes a very nominal amount of on-board energy. The advantages offered by the solar radiation pressure have drawn the attention of several researchers. Various controllers were proposed for many space missions, particularly for attitude control and stabilization of satellites. A controller for achieving large angle pitch attitude maneuver is described. The proposed control law is very simple in its form and requires a minimum number of on-board computations. Varieties of cases are tried and the effect of various parameters is studied 相似文献