Individual differences in susceptibility to motion sickness among six Skylab astronauts

One of the Skylab experiments dealt with motion sickness, comparing susceptibility in the workshop aloft with susceptibility preflight and postflight. Tests were conducted on and after mission-day 8 (MD 8) by which time the astronauts were adapted to working conditions. Stressful accelerations were generated by requiring the astronauts, with eyes covered, to execute standardized head movements (front, back, left, and right) while in a chair that could be rotated at angular velocities up to 30 rpm. The selected endpoint was either 150 discrete head movements or a very mild level of motion sickness. In all rotation experiments aloft, the five astronauts tested (astronaut 1 did not participate) were virtually symptom free, thus demonstrating lower susceptibility aloft than in preflight and postflight tests on the ground when symptoms were always elicited. Inasmuch as the eyes were covered and the canalicular stimuli were the same aloft as on the ground, it would appear that lifting the stimulus to the otolith organs due to gravity was an important factor in reducing susceptibility to motion sickness even though the transient stimuli generated under the test conditions were substantial and abnormal in pattern. Some of the astronauts experienced motion sickness under operational conditions aloft or after splashdown, but attention is centered chiefly on symptoms manifested in zero gravity. None of the Skylab-II crew (astronauts 1 to 3) was motion sick aloft. Astronaut 6 of the Skylab-III crew (astronauts 4 to 6) experienced motion sickness within an hour after transition into orbit; this constitutes the earliest such diagnosis on record under orbital flight conditions. The eliciting stimuli were associated with head and body movements, and astronaut 6 obtained relief by avoiding such movements and by one dose of the drug combination 1-scopolamine 0.35 mg + d-amphetamine 5.0 mg. All three astronauts of Skylab-III experienced motion sickness in the workshop where astronaut 6 was most susceptible and astronaut 4, least susceptible. The higher susceptibility of SL-III crewmen in the workshop, as compared with SL-II crewmen, may be attributable to the fact that they were based in the command module less than one-third as long as SL-II crewmen. The unnatural movements, often resembling acrobatics, permitted in the open spaces of the workshop revealed the great potentialities in weightlessness for generating complex interactions of abnormal or unusual vestibular and visual stimuli. Symptoms were controlled by body restraint and by drugs, but high susceptibility to motion sickness persisted for 3 days and probably much longer; restoration was complete on MD 7. From the foregoing statements it is clear that on and after MD 8 the susceptibility of SL-II and SL-III crewmen to motion sickness under experimental conditions was indistinguishable. The role played by the acquisition of adaptation effects prior to MD 8 is less clear and is a subject to be discussed.     

Skylab experiment M-092: results of the first manned mission

Blood pressure at 30-sec intervals, heart rate, and percentage increase in leg volume continuously were recorded during a 25-min protocol in the M092 Inflight Lower Body Negative Pressure (LBNP) experiment carried out in the first manned Skylab mission. These data were collected during six tests on each crewman over a 5-month preflight period. The protocol consisted of a 5-min resting control period, 1 min at -8, 1 min at -16, 3 min at -30, 5 min at -40, and 5 min at -50 mm Hg LBNP. A 5-min recovery period followed. Inflight tests were performed at approximately 3-day intervals through the 28-day mission. Individual variations in cardiovascular responses to LBNP during the preflight period continued to be demonstrated in the inflight tests. Measurements of the calf indicated that a large volume of fluid was shifted out of the legs early in the flight and that a slower decrease in leg volume, presumably due to loss of muscle tissue, continued throughout the flight. Resting heart rates tended to be low early in the flight and to increase slightly as the flight progressed. Resting blood pressure varied but usually was characterized by slightly elevated systolic blood pressure, lower diastolic pressure, and higher pulse pressures than during preflight examinations. During LBNP inflight a much greater increase in leg volume occurred than in preflight tests. Large increases occurred even at the smallest levels of negative pressure, suggesting that the veins of the legs were relatively empty at the beginning of the LBNP. The greater volume of blood pooled in the legs was associated with greater increases of heart rate and diastolic pressure and larger falls of systolic and pulse pressure than seen in preflight tests. The LBNP protocol represented a greater stress inflight, and on three occasions it was necessary to stop the test early because of impending syncopal reactions. LBNP responses inflight appeared to predict the degree of postflight orthostatic intolerance. Postflight responses to LBNP during the first 48 hours were characterized by marked elevations of heart rate and instability of blood pressure. In addition, systolic and diastolic pressures were typically elevated considerably both at rest and also during stress. The time required for cardiovascular responses to return to preflight levels was much slower than in the case of Apollo crewmen.     

Choroidal responses in microgravity. (SLS-1, SLS-2 and hindlimb-suspension experiments)

Fluid and electrolyte shifts occuring during human spaceflight have been reported and investigated at the level of blood, cardio-vascular and renal responses. Very few data were available concerning the cerebral fluid and electrolyte adaptation to microgravity, even in animal models. It is the reason why we developed several studies focused on the effects of spaceflight (SLS-1 and SLS-2 programs, carried on NASA STS 40 and 56 missions, which were 9- and 14-day flights, respectively), on structural and functional features of choroid plexuses, organs which secrete 70–90 % of cerebrospinal fluid (CSF) and which are involved in brain homeostasis. Rats flown aboard space shuttles were sacrificed either in space (SLS-2 experiment, on flight day 13) or 4–8 hours after landing (SLS-1 and SLS-2 experiments). Quantitative autoradiography performed by microdensitometry and image analysis, showed that lateral and third ventricle choroid plexuses from rats flown for SLS-1 experiment demonstrated an increased number (about x 2) of binding sites to natriuretic peptides (which are known to be involved in mechanisms regulating CSF production). Using electron microscopy and immunocytochemistry, we studied the cellular response of choroid plexuses, which produce cerebrospinal fluid (CSF) in brain lateral, third and fourth ventricles. We demonstrated that spaceflight (SLS-2 experiment, inflight samples) induces changes in the choroidal cell structure (apical microvilli, kinocilia organization, vesicle accumulation) and protein distribution or expression (carbonic anhydrase II, water channels,…). These observations suggested a loss of choroidal cell polarity and a decrease in CSF secretion. Hindlimb-suspended rats displayed similar choroidal changes. All together, these results support the hypothesis of a modified CSF production in rats during long-term (9, 13 or 14 days) adaptations to microgravity.     

Continuous tracking of cmes using MICA, andLASCO C2 and C3 coronagraphs

In this work we have tracked coronal mass ejections observed with the ground based Mirror Coronagraph for Argentina (MICA) and the Large Angle and Spectroscopic Coronagraph (LASCO) C2 and C3 on board of the Solar and Heliospheric Observatory (SOHO). The MICA telescope is located at El Leoncito (31.8 S, 69.3 W), San Juan (Argentina), since 1997 as part of a bilateral scientific project between Germany and Argentina. SOHO is a project of international cooperation between ESA and NASA. Together these instruments are able to observe the solar corona ranging from 1.05 to 32 solar radii. MICA images the Fe XIV emission line corona and LASCO coronagraphs observe the Thomson scattered white light corona. We have selected events for which there are observations from the three coronagraphs. Using the composite data we were able to obtain height-time diagrams for the corresponding dynamical coronal features traveling outwards in order to determine some of their kinematical properties, i.e., plane of sky velocity and acceleration.     

Surface tension-driven flows in horizontal liquid metal layers

The problem of surface tension-driven flows in horizontal liquid layers has been studied experimentally, and theoretically by direct numerical simulation and small perturbation analysis. We focus our attention on situations in which the depth of the fluid (liquid tin; small Prandtl number, Pr=0.015) is small enough to ensure the predominance of the surface tension forces over those due to the buoyancy. The surface velocity has been experimentally obtained for liquid tin layer with various aspect ratio (length to height) in the range 5<A<83. The thermal gradients are ranged from 5 to 40°K/cm. In the numerical study, the Navier-Stokes and energy equations are solved by an efficient finite difference technique. The parameters governing the flow behaviour in the liquid are varied to determine their effects on thermocapillary convection: the Reynolds number 10<Re<210⁴ and the aspect ratio 2<A<25; with Pr kept constant at Pr=0.015. The linear eigenequation resulting from small spatial disturbances of the Couette flow solution is solved using an Tau-Chebyshev approximation. A notable feature of the theoretical study is the totally different end circulations. In the region near the cold wall a multicell structure is evident. This agrees with the eigensolution which is of complex type, indicating spatial periodicity. In the hot wall region the flow is accelerated to reach the velocity value for the fully-developed Couette flow which is reached under conditions such as Re/A<20. The transition from viscous to boundary layer regime occurs for a critical value (Re/A)_c of nearly about 200, as deduced from the numerical and experimental results.     

CRV investment offers safe return

The development and testing of a new emergency Crew Return Vehicle (CRV) prototype is discussed. The new CRV is being developed by NASA and ESA and is designed for use on the International Space Station as a supplement to the Soyuz ships of the Russians, which accommodate only three passengers. The new vehicle will provide a shirt-sleeve environment for up to six astronauts and will allow for emergency medical treatment to be provided.     

High Excitation ISM and Gas

An overview is given of ISO results on regions of high excitation ISM and gas, i.e. HII regions, the Galactic Centre and Supernova Remnants. IR emission due to fine-structure lines, molecular hydrogen, silicates, polycyclic aromatic hydrocarbons and dust are summarised, their diagnostic capabilities illustrated and their implications highlighted. Based on observations with ISO, an ESA project with instruments funded by ESA Member States (especially the PI countries: France, Germany, The Netherlands, and the United Kingdom), and with the participation of ISAS and NASA.     

A Correlation Polarimeter for Noise-Like Signals

Optimum estimation (tracking) of the polarization plane of a linearly polarized electromagnetic wave is determined when the signal is a narrow-band Gaussian random process with a polarization plane angle which is also a Gaussian random process. This model is Compared to previous work and is applicable to space communication. The estimator performs a correlation operation similar to an amplitude -comparison monopulse angle tracker, giving the name correlation polarimeter. Under large signal-to-noise ratio (SNR), the estimator is causal. Performance of the causal correlation polarimeter is evaluated for arbitrary SNR. Optimum precorrelation filtering is determined. With low SNR, the performance of this system is far better than that of previously developed systems. Practical implementation is discussed. A scheme is given to reduce the effect of linearly polarized noise.     

Silicon Solar Cell Performance at High Intensities

The theoretical and experimental work performed since 1960 in the area of high-intensity and high-temperature operation of silicon and gallium arsenide photovoltaic devices is reviewed. Test results for conventional 5-grid silicon cells, for specially designed 13-grid silicon cells, and for a GaAs cell are presented parametrically for the illumination intensity range from 0.07 to 2.8 W/cm2 and the temperature range from 30 to 1 50°C. The data cover the 3 points on the currentvoltage characteristic required to reconstruct the full characteristic in the power-generating quadrant. The 13-grid silicon cells showed much better performance than the GaAs cell.     

Refractive Errors in Angle-of-Elevation Measurements

It is shown that the errors associated with radio elevation measurements may be investigated systematically using a variational technique. The error occurring when spaced antennas are used is compared with that for a single directional antenna. Integral expressions are obtained for the refractive errors.