Issues of exploration: human health and wellbeing during a mission to Mars.

Today, the tools are in our hands to enable us to travel away from our home planet and become citizens of the solar system. Even now, we are seriously beginning to develop the robust infrastructure that will make the 21st century the Century of Space Travel. But this bold step must be taken with due concern for the health, safety and wellbeing of future space explorers. Our long experience with space biomedical research convinces us that, if we are to deal effectively with the medical and biomedical issues of exploration, then dramatic and bold steps are also necessary in this field. We can no longer treat the human body as if it were composed of muscles, bones, heart and brain acting independently. Instead, we must lead the effort to develop a fully integrated view of the body, with all parts connected and fully interacting in a realistic way. This paper will present the status of current (2000) plans by the National Space Biomedical Research Institute to initiate research in this area of integrative physiology and medicine. Specifically, three example projects are discussed as potential stepping stones towards the ultimate goal of producing a digital human. These projects relate to developing a functional model of the human musculoskeletal system and the heart.     

Gravisensing: ionic responses, cytoskeleton and amyloplast behavior.

In Zea mays L., changes in orientation of stems are perceived by the pulvinal tissue, which responds to the stimulus by differential growth resulting in upward bending of the stem. Gravity is perceived in the bundle sheath cells, which contain amyloplasts that sediment to the new cell base when a change in the gravity vector occurs. The mechanism by which the mechanical signal is transduced into a physiological response is so far unknown for any gravity perceiving tissue. It is hypothesized that this involves interactions of amyloplasts with the plasma membrane and/or ER via cytoskeletal elements. To gain further insights into this process we monitored amyloplast movements in response to gravistimulation. In a pharmacological approach we investigated how the dynamics of plastid sedimentation are affected by actin and microtubule (MT) disrupting drugs. Dark grown caulonemal filaments of the moss Physcomitrella patens respond to gravity vector changes with a reorientation of tip growth away from the gravity vector. MT distributions in tip cells were monitored over time and MTs were seen to accumulate preferentially on the lower flank of the tip 30 min after a 90 degree turn. Using a self-referencing Ca2+ selective ion probe, we found that growing caulonemal filaments exhibit a Ca2+ influx at the apical dome, similar to that reported previously for other tip growing cells. However, in gravistimulated Physcomitrella filaments the region of Ca2+ influx is not confined to the apex, but extends about 60 micrometers along the upper side of the filament. Our results indicate an asymmetry in the Ca2+ flux pattern between the upper and side of the filament suggesting differential activation of Ca2+ permeable channels at the plasma membrane.     

Analysis of the Cyclotron Facility calibration and aircraft dosimetry results from the LIULIN-3M instrument.

The LIULIN-3M instrument is a further development of the LIULIN dosimeter-radiometer, used on the MIR spacestation during the 1988-1994 time period. The LIULIN-3M is designed for continuous monitoring of the radiation environment during the BION-12 satellite flight in 1999. A semiconductor detector with 1 mm thickness and cm2 area is contained in the instrument. Pulse high analysis technique is used to determine the energy losses in the detector. The final data from the instrument are the flux and the dose rate for the exposure time and 256 channels of absorbed dose spectra based on the assumption that the particle flux is normal to the detector. The LIULIN-3M instrument was calibrated by proton fluxes with different energies at the Indiana University Cyclotron Facility in June 1997 and had been used for radiation measurements during commercial aircraft flights. The calibration procedure and some flight results are presented in this paper.     

Indirect search for Dark Matter with H.E.S.S.

Observations of the Galactic center region with the H.E.S.S. telescopes have established the existence of a steady, extended source of gamma-ray emission coinciding with the position of the super massive black hole Sgr A^*. This is a remarkable finding given the expected presence of dense self-annihilating Dark Matter in the Galactic center region. The self-annihilation process is giving rise to gamma-ray production through hadronization including the production of neutral pions which decay into gamma-rays but also through (loop-suppressed) annihilation into final states of almost mono-energetic photons. We study the observed gamma-ray signal (spectrum and shape) from the Galactic center in the context of Dark Matter annihilation and indicate the prospects for further indirect Dark Matter searches with H.E.S.S.     

Hermes vehicle

The presence of Europe in the future developments of spatial programs, which are foreseen, for the 1990s and further, needs the availability of vehicles, modules and all related technologies adapted to operational use of low earth orbit station.The manned HERMES vehicle shall be part of the in-orbit infrastructure realized either in the European context or in cooperation between Europe and the United States.The main mission for this vehicle will be to run a shuttle with the station that means transport and change of the crews, its safe return in abort condition and cargo transport of consumable and experimental equipment.Secondary missions could be servicing on automatic platform, making autonomous scientific experiments. Lastly, the vehicle, by means of its on-board propulsion capability, could be used to accomplish in-orbit tow and assembly missions.Studies which are undertaken now about the vehicle are devoted to the aerodynamic shape (research of a compromise between aerothermic and overall fitting), the system (functional architecture, ground and flight configuration); further works dealing with technology are presently on hand in the field of thermal protection, aerodynamics, power generation with a high massic yield.     

A space radiation transport method development.

Improved spacecraft shield design requires early entry of radiation constraints into the design process to maximize performance and minimize costs. As a result, we have been investigating high-speed computational procedures to allow shield analysis from the preliminary design concepts to the final design. In particular, we will discuss the progress towards a full three-dimensional and computationally efficient deterministic code for which the current HZETRN evaluates the lowest-order asymptotic term. HZETRN is the first deterministic solution to the Boltzmann equation allowing field mapping within the International Space Station (ISS) in tens of minutes using standard finite element method (FEM) geometry common to engineering design practice enabling development of integrated multidisciplinary design optimization methods. A single ray trace in ISS FEM geometry requires 14 ms and severely limits application of Monte Carlo methods to such engineering models. A potential means of improving the Monte Carlo efficiency in coupling to spacecraft geometry is given in terms of re-configurable computing and could be utilized in the final design as verification of the deterministic method optimized design.     

Indicators of black-hole mass and Eddington accretion ratio from QSO X-ray and UV spectra

The evolution of luminous QSOs is linked to the evolution of massive galaxies. We know this because the relic black-holes found locally have masses dependent on the properties of the host galaxy’s bulge. An important way to explore this evolution would be to measure dependences of black-hole masses and Eddington accretion ratios over a range of redshifts, i.e., with cosmological age. For low redshift QSOs (and their lower luminosity Seyfert galaxy counterparts) it has been possible to infer black-hole masses from the luminosities and velocity dispersions of their host-galaxy bulges. These masses agree with those virial black-hole masses calculated from the Doppler widths of the broad Hβ emission lines. The latter method can then be extended to more distant and luminous QSOs, up to redshifts of 0.6 with ground-based optical observations. We discuss ways to extend these explorations to higher redshifts – up to 3 using the widths of QSOs’ broad UV emission lines, and in principle, and to redshifts near 4 from ground-based infrared observations of rest-frame Hβ at 2.5 μm. We discuss the possibility of investigating the accretion history of the higher redshift QSOs using measures of Eddington accretion ratio – the soft X-ray spectral index and the eigenvectors of Principal Components Analyses of QSOs’ UV emission-line spectra.     

Linear parametrically varying systems with brief instabilities: an application to vision/inertial navigation

This paper addresses the problem of nonlinear filter design to estimate the relative position and velocity of an unmanned air vehicle (UAV) with respect to a point on a ship using infrared (IR) vision, inertial, and air data sensors. Sufficient conditions are derived for the existence of a particular type of complementary filters with guaranteed stability and performance in the presence of so-called out-of-frame events that arise when the vision system loses its target temporarily. The results obtained build upon new developments in the theory of linear parametrically varying systems (LPVs) with brief instabilities - also reported in the paper - and provide the proper framework to deal with out-of-frame events. Field tests with a prototype UAV illustrate the performance of the filter and the scope of applications of the new theory developed.     

Mathematical modeling of heat transfer process in a variable domain

In this paper, a brief review and generalization of studies on the heat transfer and heat conduction problem in a variable domain are presented. The equations of the process, where the boundary displacement velocity is the control, are obtained taking into account heat inflow. This article was submitted by the authors in English.     

Summary of recent Australian radar developments

Over the last 30 years there has been a growing Australian capability in very long-range radar systems, especially over the horizon radar (OTHR) and a related technology, surface wave radar (SWR). Both operate in the high frequency (HF) band between 3 and 30 MegaHertz (MHz), which are wavelengths between 100 and 10 metres, respectively. Based on current evidence, it appears that Australia may have found the tools with which to conduct efficient long-range surface and air surveillance more effectively than by the single use of traditional surveillance forces. Given increasing success and refinement of these technologies, one can see that the SWR systems in particular could, in addition, satisfy a number of potential export requirements and earn useful export credits.