Induction of genomic instability after an acute whole-body exposure of mice to Fe ions

The purpose of this study was to evaluate dose–response relationships for the in vivo induction of micronuclei (MN) as a measure of both initial radiation damage and the induction of genomic instability. These measurements were made in mouse blood erythrocytes as a function of radiation dose, radiation quality, time after irradiation, and the genetic background of exposed individuals. Blood samples were collected from two strains of mouse (CBA/CaJ and C57BL/6J) at different times up to 3 months following a whole-body exposure to various doses of 1 GeV/amu ⁵⁶Fe ions (0, 0.1, 0.5 and 1.0 Gy, at the dose rate of a 1 Gy/min) or ¹³⁷Cs gamma rays (0, 0.5, 1.0 and 3.0 Gy, at the dose rate of 0.72 Gy/min). Blood-smear slides were stained with acridine orange (AO). The frequencies of MN were measured in mature normochromatic-erythrocytes (MN-NCEs) and in immature polychromatic-erythrocytes (MN-PCEs). Effects of both types of radiation on erythropoiesis were also evaluated. As a measure of cell progression delay, a dose-dependent decrease in numbers of PCEs was observed at day 2 post-exposure in both strains, regardless of radiation quality. Subsequently, the levels of PCEs increased in all exposed mice, reaching control levels (or higher) by day 7 post-exposure. Further, at day 2 after the exposure, there was no increase in the frequency of MN-PCEs in CBA/CaJ mice exposed to ⁵⁶Fe ions while the frequency of MN-PCEs elevated as a function of dose in the C57BL/6J mice. At day 4, there was no dose related increase in MN-NCEs in either strain of mouse exposed to ¹³⁷Cs gamma rays. Additionally, at the early sacrifice times (days 2 and 4), ⁵⁶Fe ions were slightly more effective (per unit dose) in inducing MN-NCEs than ¹³⁷Cs gamma rays in CBA/CaJ mice. However, there was no increase in the frequency of MN-NCEs at late times after an acute exposure to either type of radiation. In contrast, both types of radiation induced increased MN-PCEs frequencies in irradiated CBA/CaJ mice, but not C57BL/6J mice, at late times post-exposure. This finding indicates the potential induction of genomic instability in hematopoietic cells of CBA/CaJ mice by both types of radiation. The finding also demonstrates the influence of genetic background on radiation-induced genomic instability in vivo.     

Short-term variation of cosmic ray diurnal anisotropy and solar activity

A correlative analysis has been made between cosmic ray intensity and solar activity (sunspot numbers) during high amplitude days for the period 1991–1995. The high amplitude days with the time of maximum in the corotational/azimuthal direction do not indicate any significant correlation with solar activity. The diurnal amplitude significantly remains constant and high (0.5%) during the entire period. Our observations suggest that the direction of the anisotropy of high amplitude anisotropic wave train events contribute significantly to the short-term behavior of the cosmic ray diurnal anisotropy. The correlation coefficient is found to remain positive during solar activity maximum for all the high amplitude anisotropic wave train events.     

Optimization of transfers under constraints on the thrust direction: II

This paper completes the study of optimal transfers with constraints imposed on the thrust vector direction that was opened by paper [1]. The linear inhomogeneous and homogeneous constraints on the thrust direction are considered (specified either by equalities or inequalities), as well as mixed constraints. Some examples of the constraints are presented. A modified method of the transporting trajectory is applied in order to find the optimal transfer under the linear constraints on the thrust direction. This method also gives the necessary condition for a transfer possibility at a given constraint on the thrust direction. A numerical example is considered, in which the propellant consumption is analyzed for the cases of transfers with and without constraints.     

Energy dependence of the characteristic decay time of proton fluxes in solar cosmic ray events

Energetic solar proton events within the energy interval 1–48 MeV at the stage of their decay are considered over the period of 1974–2001. The dependence of the characteristic decay time on the proton energy in the assumed power-law representation τ(E) =E ^?n is analyzed for the events with an exponential decay form. The dependence of n on the heliolongitude of the flare (the particles source on the Sun) is studied.     

Optimization of multi-mode rendezvous trajectories with constraints

Approximate numerical methods of optimization of spacecraft rendezvous trajectories are presented that make use of interior point algorithms for problems of linear programming of high dimensionality (tens to hundreds of thousands of variables). The basis of the methods is discretization of a trajectory into small segments in which maneuvers are allowed to be executed; for all segments sets of pseudo-impulses are introduced that determine the possible directions of the spacecraft thrust vector. The terminal conditions are presented in the form of a linear matrix equation. A matrix inequality for the sums of characteristic velocities of pseudo-impulses on each segment is used to make a transformation to the linear programming form. Spacecraft rendezvous trajectories are considered in the neighborhood of circular orbits with the use of multi-mode propulsion systems (including those with low thrust) and existence of boundary conditions at interior points and constraints on the time of operation of the propulsion system at separate segments of the trajectory.     

Identification of sources of Pc1 geomagnetic pulsations on the basis of proton aurora observations

The relationship between proton aurora and geomagnetic pulsations Pc1, which are an indicator of development of ion-cyclotron instability in the equatorial magnetosphere, are studied on the basis of the observations of proton aurora from the IMAGE satellite, observations of particle fluxes onboard the low-orbiting NOAA satellites, and geomagnetic pulsation observations at the Lovozero observatory. A conclusion is drawn that the subauroral spots in the proton emission projected into the magnetosphere near the plasmapause are two-dimensional images at the ionospheric “screen” of the region of intense scattering of energetic protons into the loss cone at the development of an ion-cyclotron instability.     

Alfven modes of solar coronal magnetic arches: Excitation of ballooning instability and modulation of flare emission

The effect of Alfven-type oscillations in a coronal magnetic arch on modulation of the gyrosynchrotron radiation and development of the ballooning instability in the arch is considered. On the basis of the energy method and the method of normal modes, the expressions are obtained for increments of ballooning instability at its swinging by natural oscillations of the arch. The conclusion is drawn that bending oscillations, which do not actually compress the plasma and, therefore, represent the Alfven-type modes, unlike the radial oscillations, are capable, under solar corona conditions, to effectively swing ballooning instability and, as a consequence, play a part of a trigger for solar flares. The ballooning instability of coronal arches is shown to be capable of causing formation of helmet-shaped structures in the lower solar corona. On the basis of calculations of the intensity modulation depth and the degree of circular polarization of non-thermal gyrosynchrotron radiation, under the assumption of excited Alfven oscillations of a coronal arch, the conclusion is drawn, that microwave observations at a frequency of > 10 GHz can be used for studying the conditions of excitation and propagation of Alfven modes in flare loops. The consequences of obtained results are discussed using the flare on April 15, 2002 as an example.     

Planetary waves according to simultaneous observations of <Emphasis Type="Italic">GPS</Emphasis> satellites and ground-based magnetic stations

On the basis of measurements made at Japanese magnetic stations and using GPS satellites for the 12 months of 2003, a comparison of simultaneous variations of three components of the magnetic field and total electron content (TEC) was carried out in the range of the planetary waves period. The correlation analysis has shown that almost synchronous variations exist within this range of periods at the ground-based magnetometer stations and in the TEC measurements both during strong magnetic disturbances and in quiet periods. The strong magnetic disturbances could be considered as a possible independent source of ionospheric variations within the planetary waves range, while the accompanying ionospheric storms could be a possible factor changing the conductivity of the lower ionosphere plasma. In quiet periods, the correlation of magnetic variations and disturbances in TEC is caused by the direct impact of atmospheric planetary waves on the lower ionosphere and can be related to variations of ionospheric currents due to the dynamo mechanism.     

An analysis of low-frequency component in microacceleration measurements made onboard the <Emphasis Type="Italic">Foton M-2</Emphasis> satellite

The low-frequency component is investigated in the data of measurements performed onboard the Foton M-2 satellite with the three-component accelerometer TAS-3. Investigations consisted in comparison of this component with its calculated analog found from a reconstruction of the satellite’s attitude motion. The influence of the Earth’s magnetic field on the accelerometer readings is discovered by way of spectral analysis of the functions representing the results of determining the low-frequency microacceleration by two methods. After making correction for this influence, the results obtained by these two methods coincided within a root-mean-square error of less than 10^?6 m/s².     

Proton fluxes measured by low-orbit satellites

In this paper we consider the fluxes of protons in the energy range from 30 keV to 140 MeV recorded by instruments onboard the Russian satellites KORONAS-F and UNIVERSITETSKII and on the American satellites GOES-11 and NOAA-17. In order to estimate the reliability of the obtained data, the comparison of measurements of separate energy channels of these instruments between themselves is performed. Experimental fluxes of trapped protons are compared with the fluxes predicted by the AP8 model.