Biodosimetry of heavyions by interphase chromosome painting

We report measurements of chromosomal aberrations in peripheral blood lymphocytes from cancer patients undergoingradiotherapy treatment. Patients with cervix or esophageal cancer were treated with 10 MV X-rays produced at a LINAC accelerator, or high-energy carbon ions produced at the HIMAC accelerator at the National Institute for Radiological Sciences (NIRS) in Chiba. Blood samples were obtained before, during, and after the radiation treatment. Chromosomes were prematurely condensed by incubation in calyculin A. Aberrations in chromosomes 2 and 4 were scored after fluorescence in situ hybridization with whole-chromosome probes. Pre-treatment samples were exposed in vitro to X-rays, individual dose-response curves for the induction of chromosomal aberrations were determined, and used as calibration curves to calculate the effective whole-body dose absorbed during the treatment. This calculated dose, based on the calibration curve relative to the induction of reciprocal exchanges, has a sharp increase after the first few fractions of the treatment, then saturates at high doses. Although carbon ions are 2–3 times more effective than X-rays in tumor sterilization, the effective dose was similar to that of X-ray treatment. However, the frequency of complex-type chromosomal exchanges was much higher for patients treated with carbon ions than X-ray.     

High resolution time profile of decimetric type-III bursts

Type-III bursts are signatures of the electron beams accelerated during the solar flares, their observation and investigation provide information of the acceleration processes, the characteristics of the exciting agent and the acceleration site. The Brazilian Solar Spectroscope (BSS), in operation at INPE, Brazil, have recorded type-III radio bursts in decimetric range (2050–2250 MHz) with high time resolution of 20 ms. Decimetric reverse drift bursts are possibly generated in a dense loop by electron beams travelling towards the photosphere. Hence their time profiles should carry signatures of the density inhomogenities in the loop. Here the temporal and spectral characteristics of decimetric type-III bursts are presented.     

Huygens Probe Aerosol Collector Pyrolyser Experiment

ACP's main objective is the chemical analysis of the aerosols in Titan's atmosphere. For this purpose, it will sample the aerosols during descent and prepare the collected matter (by evaporation, pyrolysis and gas products transfer) for analysis by the Huygens Gas Chromatograph Mass Spectrometer (GCMS). A sampling system is required for sampling the aerosols in the 135'32 km and 22'17 km altitude regions of Titan's atmosphere. A pump unit is used to force the gas flow through a filter. In its sampling position, the filter front face extends a few mm beyond the inlet tube. The oven is a pyrolysis furnace where a heating element can heat the filter and hence the sampled aerosols to 250 °C or 600 °C. The oven contains the filter, which has a thimble-like shape (height 28 mm). For transferring effluent gas and pyrolysis products to GCMS, the carrier gas is a labeled nitrogen ¹⁵N₂, to avoid unwanted secondary reactions with Titan's atmospheric nitrogen. Aeraulic tests under cold temperature conditions were conducted by using a cold gas test system developed by ONERA. The objective of the test was to demonstrate the functional ability of the instrument during the descent of the probe and to understand its thermal behavior, that is to test the performance of all its components, pump unit and mechanisms. In order to validate ACP's scientific performance, pyrolysis tests were conducted at LISA on solid phase material synthesized from experimental simulation. The chromatogram obtained by GCMS analysis shows many organic compounds. Some GC peaks appear clearly from the total mass spectra, with specific ions well identified thanks to the very high sensitivity of the mass spectrometer. The program selected for calibrating the flight model is directly linked to the GCMS calibration plan. In order not to pollute the two flight models with products of solid samples such as tholins, we excluded any direct pyrolysis tests through the ACP oven during the first phase of the calibration. Post probe descent simulation of flight results are planned, using the much representative GCMS and ACP spare models. This revised version was published online in August 2006 with corrections to the Cover Date.     

Progress in CMOS integrated measurement systems

Selected micro- and nano-systems developed recently at the Physical Electronics Laboratory of ETH Zurich are reviewed: (i) a fluxgate microsystem for detection of the Earth's magnetic field; (ii) a capacitive chemical sensor microsystem for detection of volatile organic compounds in air; and (iii) a parallel scanning AFM chip. The micro- and nano-systems combine sensor structures and readout circuitry on a single chip and are fabricated using industrial CMOS technology in combination with post-processing micromachining and film deposition     

Dynamics of a spacecraft and normalization around Lagrangian points in the Neptune–Triton system

The problem of a spacecraft orbiting the Neptune–Triton system is presented. The new ingredients in this restricted three body problem are the Neptune oblateness and the high inclined and retrograde motion of Triton. First we present some interesting simulations showing the role played by the oblateness on a Neptune’s satellite, disturbed by Triton. We also give an extensive numerical exploration in the case when the spacecraft orbits Triton, considering Sun, Neptune and its planetary oblateness as disturbers. In the plane a × I (a = semi-major axis, I = inclination), we give a plot of the stable regions where the massless body can survive for thousand of years. Retrograde and direct orbits were considered and as usual, the region of stability is much more significant for the case of direct orbit of the spacecraft (Triton’s orbit is retrograde). Next we explore the dynamics in a vicinity of the Lagrangian points. The Birkhoff normalization is constructed around L₂, followed by its reduction to the center manifold. In this reduced dynamics, a convenient Poincaré section shows the interplay of the Lyapunov and halo periodic orbits, Lissajous and quasi-halo tori as well as the stable and unstable manifolds of the planar Lyapunov orbit. To show the effect of the oblateness, the planar Lyapunov family emanating from the Lagrangian points and three-dimensional halo orbits are obtained by the numerical continuation method.     

Radar Doppler Spectra of Turbulent Ionized Wakes

The evaluation of the double convolution integrat involved in the expression of the radar response to scattering from a turbulent ionized wake is simplified by the approximation technique presented here, so that the Doppler spectrum parameters can be explicitly expressed in terms of the wake characteristics.     

Multiple Beam Satellite System Optimization

An analytical method is developed for determining the basic RF link parameters that are required in a satellite system design. Certain simplifying assumptions are required and specific system elements are selected. Two different design criteria are considered; optimizing the per-beam signal energy to noise spectral density ratio (Eb/N0), and minimizing the per-user costs. These two criteria are complements of each other subject to coverage and performance constraints. The model can be used to rapidly assess tradeoffs in various system elements. A specific example of a domestic satellite system is considered. The economic analyses are also considered and the economy of scale effect is demonstrated for the design example and considered.     

New evidence for strong non-thermal effects in Tycho’s supernova remnant

For the case of Tycho’s supernova remnant (SNR), we present the relation between the blast wave and contact discontinuity radii calculated within the nonlinear kinetic theory of cosmic ray (CR) acceleration in SNRs. It is demonstrated that these radii are confirmed by recently published Chandra measurements which show that the observed contact discontinuity radius is very close to the shock radius. Therefore a consistent explanation of these observations can be given in terms of efficient CR acceleration which makes the medium more compressible.