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81.
Although the space radiation environment consists predominantly of energetic protons, astronauts inside a spacecraft are chronically exposed to both primary particles as well as secondary particles that are generated when the primary particles penetrate the spacecraft shielding. Secondary neutrons and secondary charged particles can have an LET value that is greater than the primary protons and, therefore, produce a higher relative biological effectiveness (RBE). Using the accelerator facility at Loma Linda University, we exposed human lymphocytes in vitro to 250 MeV protons with doses ranging from 0 to 60 cGy at three different dose rates: a low dose rate of 7.5 cGy/h, an intermediate dose rate of 30 cGy/h and a high dose rate of 70 cGy/min. The effect of 15 g/cm2 aluminum shielding on the induction of chromosome aberrations was investigated for each dose rate. After exposure, lymphocytes were incubated in growth medium containing phytohemagglutinin (PHA) and chromosome spreads were collected using a chemical-induced premature chromosome condensation (PCC) technique. Aberrations were analyzed using the fluorescence in situ hybridization (FISH) technique with three different colored chromosome-painting probes. The frequency of reciprocal and complex-type chromosome exchanges were compared in shielded and unshielded samples.  相似文献   
82.
Planetary upper atmospheres-coexisting thermospheres and ionospheres-form an important boundary between the planet itself and interplanetary space. The solar wind and radiation from the Sun may react with the upper atmosphere directly, as in the case of Venus. If the planet has a magnetic field, however, such interactions are mediated by the magnetosphere, as in the case of the Earth. All of the Solar System’s giant planets have magnetic fields of various strengths, and interactions with their space environments are thus mediated by their respective magnetospheres. This article concentrates on the consequences of magnetosphere-atmosphere interactions for the physical conditions of the thermosphere and ionosphere. In particular, we wish to highlight important new considerations concerning the energy balance in the upper atmosphere of Jupiter and Saturn, and the role that coupling between the ionosphere and thermosphere may play in establishing and regulating energy flows and temperatures there. This article also compares the auroral activity of Earth, Jupiter, Saturn and Uranus. The Earth’s behaviour is controlled, externally, by the solar wind. But Jupiter’s is determined by the co-rotation or otherwise of the equatorial plasmasheet, which is internal to the planet’s magnetosphere. Despite being rapid rotators, like Jupiter, Saturn and Uranus appear to have auroral emissions that are mainly under solar (wind) control. For Jupiter and Saturn, it is shown that Joule heating and “frictional” effects, due to ion-neutral coupling can produce large amounts of energy that may account for their high exospheric temperatures.  相似文献   
83.
The James Webb Space Telescope   总被引:4,自引:0,他引:4  
The James Webb Space Telescope (JWST) is a large (6.6 m), cold (<50 K), infrared (IR)-optimized space observatory that will be launched early in the next decade into orbit around the second Earth–Sun Lagrange point. The observatory will have four instruments: a near-IR camera, a near-IR multiobject spectrograph, and a tunable filter imager will cover the wavelength range, 0.6 < ; < 5.0 μ m, while the mid-IR instrument will do both imaging and spectroscopy from 5.0 < ; < 29 μ m.The JWST science goals are divided into four themes. The key objective of The End of the Dark Ages: First Light and Reionization theme is to identify the first luminous sources to form and to determine the ionization history of the early universe. The key objective of The Assembly of Galaxies theme is to determine how galaxies and the dark matter, gas, stars, metals, morphological structures, and active nuclei within them evolved from the epoch of reionization to the present day. The key objective of The Birth of Stars and Protoplanetary Systems theme is to unravel the birth and early evolution of stars, from infall on to dust-enshrouded protostars to the genesis of planetary systems. The key objective of the Planetary Systems and the Origins of Life theme is to determine the physical and chemical properties of planetary systems including our own, and investigate the potential for the origins of life in those systems. Within these themes and objectives, we have derived representative astronomical observations.To enable these observations, JWST consists of a telescope, an instrument package, a spacecraft, and a sunshield. The telescope consists of 18 beryllium segments, some of which are deployed. The segments will be brought into optical alignment on-orbit through a process of periodic wavefront sensing and control. The instrument package contains the four science instruments and a fine guidance sensor. The spacecraft provides pointing, orbit maintenance, and communications. The sunshield provides passive thermal control. The JWST operations plan is based on that used for previous space observatories, and the majority of JWST observing time will be allocated to the international astronomical community through annual peer-reviewed proposal opportunities.  相似文献   
84.
Observations and measurements in the solar wind, the Jovian atmosphere and the gases trapped in lunar surface material provide the main evidence from which the isotopic composition of H, He and Ne in the Protosolar Cloud (PSC) is derived. These measurements and observations are reviewed and the corrections are discussed that are needed for obtaining from them the PSC isotopic ratios. The D/H, 3He/4He (D+3He)/H, 20Ne/22Ne and 21Ne/22Ne ratios adopted for the PSC are presented. Protosolar abundances provide the basis for the interpretation of isotopic ratios measured in the various solar system objects. In this article we discuss constraints derived from the PSC abundances on solar mixing, the origin of atmospheric neon, and the nature of the “SEP” component of neon trapped at the lunar surface. We also discuss constraints on the galactic evolution provided by the isotopic abundances of H and He in the PSC. This revised version was published online in August 2006 with corrections to the Cover Date.  相似文献   
85.
A tactical system designed to inspect and diagnose malfunctions in all army tactical vehicles including jeeps, trucks, and tanks is known as Ready Multipurpose Automatic Inspection and Diagnostic System (READYMAIDS). The laboratory model developed to prove the feasibility of design is discussed together with design problems such as instrumenting a vehicle without modifications. The system uses a small digital computer in addition to switching, measurement, and loading devices. These devices are integrated into a small transportable unit. Results to date, problem areas, and possible solutions are described.  相似文献   
86.
Intensity-time profiles of protons, alpha particles, and heavy ions (C, O, Fe) in the MeV/nucleon energy range have been analyzed for one solar particle event following the solar flare on September 23, 1978. The data have been obtained with the wide angle double dE/dx-E sensor of the Max-Planck-Institut/University of Maryland experiment onboard ISEE-3. We found time variations in the iron to helium ratio of up to 2 orders of magnitude and a significant variation of the O/He ratio during this event, whereas the C/O-ratio at the same energy/nucleon appears to be time independent. We investigated the influence of a rigidity dependent mean free path in interplanetary space and of rigidity dependent coronal propagation on heavy ion ratios during solar particle events. We found that both the magnitude and time scale of the ratio changes during the September 23 event cannot be explained by rigidity dependent interplanetary or coronal propagation alone. These ratio changes are probably caused by multiple injection at the sun.  相似文献   
87.
G2-chromosome aberrations induced by high-LET radiations.   总被引:1,自引:0,他引:1  
We report measurement of initial G2-chromatid breaks in normal human fibroblasts exposed to various types of high-LET particles. Exponentially growing AG 1522 cells were exposed to gamma rays or heavy ions. Chromosomes were prematurely condensed by calyculin A. Chromatid-type breaks and isochromatid-type breaks were scored separately. The dose response curves for the induction of total chromatid breaks (chromatid-type + isochromatid-type) and chromatid-type breaks were linear for each type of radiation. However, dose response curves for the induction of isochromatid-type breaks were linear for high-LET radiations and linear-quadratic for gamma rays. Relative biological effectiveness (RBE), calculated from total breaks, showed a LET dependent tendency with a peak at 55 keV/micrometer silicon (2.7) or 80 keV/micrometer carbon (2.7) and then decreased with LET (1.5 at 440 keV/micrometer). RBE for chromatid-type break peaked at 55 keV/micrometer (2.4) then decreased rapidly with LET. The RBE of 440 keV/micrometer iron particles was 0.7. The RBE calculated from induction of isochromatid-type breaks was much higher for high-LET radiations. It is concluded that the increased production of isochromatid-type breaks, induced by the densely ionizing track structure, is a signature of high-LET radiation exposure.  相似文献   
88.
Changed political objectives, straitened economic circumstances and an altered balance of capability and expertise in space endeavours have together produced more discussion of the need for international cooperation than ever before, but the meaning of the term has subtly shifted. Insisting on US ‘leadership’ is self-defeating; what is instead firmly desired by the USA's potential partners is a balanced relationship in which each nation makes an identifiable contribution and takes the lead in at least one of a package of projects. If this is going to happen, there must be an international forum or framework in which projects can be discussed and agreed. This in turn requires initiative at governmental level.  相似文献   
89.
Cytogenetic effects of energetic ions with shielding   总被引:1,自引:0,他引:1  
In order to understand the effects of shielding on the induction of biological damages by charged particles, we conducted experiments with accelerated protons (250 MeV) and iron particles (1 GeV/u). Human lymphocytes in vitro were exposed to particle beams through polyethylene with various thickness, and chromosomal aberrations were determined using FISH technique. Dose response curves for chromosome aberrations were obtained and compared for various particle types. Experimental results indicated that for a given absorbed dose at the cell, the effectiveness of protons and iron particles in the induction of chromosomal aberrations was not significantly altered by polyethylene with thickness up to 30-cm and 15-cm respectively. Comparing with gamma rays, charged particles were very effective in producing complex chromosomal damages, which may be an important mechanism in alterating functions in nondividing tissues, such as nervous systems.  相似文献   
90.
We analyzed DNA and proteins obtained from normal and transformed human mammary epithelial cells for studying the neoplastic transformation by high-LET irradiation in vitro. We also examined microsatellite instability in human mammary cells transformed to various stages of carcinogenesis, such as normal, growth variant and tumorigenic, using microsatellite marker D5S177 on the chromosome 5 and CY17 on the Chromosome 10. Microsatellite instabilities were detected in the tumorigenic stage. These results suggest that microsatellite instability may play a role in the progression of tumorigenecity. The cause of the genomic instability has been suggested as abnormalities of DNA-repair systems which may be due to one of the three reasons: 1) alterations of cell cycle regulating genes. 2) mutations in any of the DNA mismatch repair genes. 3) mutation in any of the DNA strand breaks repair genes. No abnormality of these genes and encoded proteins, however was found in the present studies. These studies thus suggest that the microsatellite instability is induced by an alternative mechanism.  相似文献   
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