Microsatellite instability in human mammary epithelial cells transformed by heavy ions

We analyzed DNA and proteins obtained from normal and transformed human mammary epithelial cells for studying the neoplastic transformation by high-LET irradiation in vitro. We also examined microsatellite instability in human mammary cells transformed to various stages of carcinogenesis, such as normal, growth variant and tumorigenic, using microsatellite marker D5S177 on the chromosome 5 and CY17 on the Chromosome 10. Microsatellite instabilities were detected in the tumorigenic stage. These results suggest that microsatellite instability may play a role in the progression of tumorigenecity. The cause of the genomic instability has been suggested as abnormalities of DNA-repair systems which may be due to one of the three reasons: 1) alterations of cell cycle regulating genes. 2) mutations in any of the DNA mismatch repair genes. 3) mutation in any of the DNA strand breaks repair genes. No abnormality of these genes and encoded proteins, however was found in the present studies. These studies thus suggest that the microsatellite instability is induced by an alternative mechanism.     

The Solar Origin of Corotating Interaction Regions and Their Formation in the Inner Heliosphere

Corotating Interaction Regions (CIRs) form as a consequence of the compression of the solar wind at the interface between fast speed streams and slow streams. Dynamic interaction of solar wind streams is a general feature of the heliospheric medium; when the sources of the solar wind streams are relatively stable, the interaction regions form a pattern which corotates with the Sun. The regions of origin of the high speed solar wind streams have been clearly identified as the coronal holes with their open magnetic field structures. The origin of the slow speed solar wind is less clear; slow streams may well originate from a range of coronal configurations adjacent to, or above magnetically closed structures. This article addresses the coronal origin of the stable pattern of solar wind streams which leads to the formation of CIRs. In particular, coronal models based on photospheric measurements are reviewed; we also examine the observations of kinematic and compositional solar wind features at 1 AU, their appearance in the stream interfaces (SIs) of CIRs, and their relationship to the structure of the solar surface and the inner corona; finally we summarise the Helios observations in the inner heliosphere of CIRs and their precursors to give a link between the optical observations on their solar origin and the in-situ plasma observations at 1 AU after their formation. The most important question that remains to be answered concerning the solar origin of CIRs is related to the origin and morphology of the slow solar wind. This revised version was published online in August 2006 with corrections to the Cover Date.     

The Composition of the Solar Wind in Polar Coronal Holes

The solar wind charge state and elemental compositions have been measured with the Solar Wind Ion Composition Spectrometers (SWICS) on Ulysses and ACE for a combined period of about 25 years. This most extensive data set includes all varieties of solar wind flows and extends over more than one solar cycle. With SWICS the abundances of all charge states of He, C, N, O, Ne, Mg, Si, S, Ar and Fe can be reliably determined (when averaged over sufficiently long time periods) under any solar wind flow conditions. Here we report on results of our detailed analysis of the elemental composition and ionization states of the most unbiased solar wind from the polar coronal holes during solar minimum in 1994–1996, which includes new values for the abundance S, Ca and Ar and a more accurate determination of the ²⁰Ne abundance. We find that in the solar minimum polar coronal hole solar wind the average freezing-in temperature is ∼1.1×10⁶ K, increasing slightly with the mass of the ion. Using an extrapolation method we derive photospheric abundances from solar wind composition measurements. We suggest that our solar-wind-derived values should be used for the photospheric ratios of Ne/Fe=1.26±0.28 and Ar/Fe=0.030±0.007.     

Johannes Geiss’ Investigations of Solar, Heliospheric and Interstellar Matter

Johannes Geiss is a world leader and foremost expert on measurements and interpretation of the composition of matter that reveals the history, present state, and future of astronomical objects. With his Swiss team he was first to measure the composition of the noble gases in the solar wind when in the late 1960s he flew the brilliant solar wind collecting foil experiments on the five Apollo missions to the moon. Always at the forefront of the art of composition measurements, he with his colleagues determined the isotopic and elemental composition of the solar wind using instruments characterized by innovative design that have provided the most comprehensive record of the solar wind composition under all solar wind conditions at all helio-latitudes. He discovered heavy interstellar pickup ions, from which the composition of the neutral gas of the Local Interstellar Cloud is determined, and the “Inner Source” of pickup ions. Johannes Geiss played a key role both in the in-situ measurements and modeling of molecular ions in comets, and the interpretation of these data. He and co-workers measured the composition of plasmas in the magnetospheres of Earth and Jupiter. Here we highlight Johannes Geiss’ many discoveries and seminal contributions to our knowledge of the composition of matter of the Sun, solar wind, interstellar gas, early universe, comets and magnetospheres.     

Abundances of Deuterium and Helium-3 in the Protosolar Cloud

The mass spectrometric determinations of the isotopic composition of helium in the solar wind obtained from (1) the Apollo Solar Wind Composition (SWC) experiment, (2) the Ion Composition Instrument (ICI) on the International Sun Earth Explorer 3 (ISEE-3), and (3) the Solar Wind Composition Spectrometer (SWICS) on Ulysses are reviewed and discussed, including new data given by Gloeckler and Geiss (1998). Averages of the 3He/4He ratio in the slow wind and in fast streams are given. Taking account of separation and fractionation processes in the corona and chromosphere, 3He/4He = (3.8 ± 0.5) × 10-4 is derived as the best estimate for the present-day Outer Convective Zone (OCZ) of the sun. After corrections of this ratio for secular changes caused by diffusion, mixing and 3He production by incomplete H-burning (Vauclair, 1998), we obtain (D + 3He)/H = (3.6±0.5) × 10-5 for the Protosolar Cloud (PSC). Adopting 3He/H = (1.5±0.2) × 10-5 for the PSC, as is indicated from the 3He/4He ratio in the planetary gas component of meteorites and in Jupiter (Mahaffy et al., 1998), we obtain (D/H)protosolar = (2.1 ± 0.5) × 10-5. Galactic evolution studies (Tosi, 1998) show that the measured D and 3He abundances in the Protosolar Cloud and the Local Interstellar Cloud (Linsky, 1998; Gloeckler and Geiss, 1998), lead to (D/H)primordial = (2 - 5) × 10-5. This range corresponds to a universal baryon/photon ratio of (6.0 ± 0.8) × 10-10, and to b = 0.075 ± 0.015.     

Interstellar and Inner Source Pickup Ions Observed with Swics on Ulysses

Many species of pickup ions, both of interstellar origin and from an inner, distributed source have been discovered using data from the Solar Wind Ion Composition Spectrometer (SWICS) on Ulysses. Velocity distribution functions of these ions were measured for the first time over heliocentric distances between 1.35 and 5.4 AU, both at high and low latitudes, and in the disturbed slow solar wind as well as the steady fast wind of the polar coronal holes. This has given us the first glance at plasma properties of suprathermal ions in various solar wind flows, and is enabling us to study the chemical and, in the case of He, the isotopic composition of the local interstellar cloud. Among the new findings are (a) the surprisingly weak pitch-angle scattering of low rigidity, suprathermal ions leading to strongly anisotropic velocity distributions in radial magnetic fields, (b) the efficient injection and consequent acceleration of pickup ions, especially He+ and H+, in the turbulent solar wind, and (c) the discovery of a new extended source releasing carbon, oxygen, nitrogen and possibly other atoms and molecules in the inner solar system. Pickup ion measurements are now used to study the characteristics of the local interstellar cloud (LIC) and, in particular, to determine accurately the abundance of atomic H, He, N, O, and Ne, the isotopes of He and Ne, as well as the ionization fractions of H and He in the LIC. Pickup ion observations allow us to infer the location of the termination shock and, in combination with measurements of anomalous cosmic rays, to investigate termination shock acceleration mechanisms. This revised version was published online in June 2006 with corrections to the Cover Date.     

Remote sensing of Earth resources: emerging opportunities for developing countries

Land information from remote sensing satellites contributes substantially to the quality of decision making in development activities. However, participation in space-related activities by developing countries has historically been low in part due to the high costs and advanced technology inputs required. The paper discusses several technological and socio-political trends which now offer increasingly affordable opportunities for developing countries to increase their level of participation in activities related to satellite remote sensing of earth resources. Benefiting from these opportunities requires appropriate encouragement and support from national governments.     

Acceleration and Composition of Solar Wind Suprathermal Tails

Observations in the solar wind have revealed important insights into how energetic particles are accelerated in astrophysical plasmas. In circumstances where stochastic acceleration is expected, a suprathermal tail on the distribution function is formed with a common spectral shape: the spectrum is a power law in particle speed with a spectral index of −5. Recent theories for this phenomenon, in which thermodynamic constraints are applied to explain the common spectral shape, are reviewed. As an example of potential extensions of this theoretical work, consideration is given to the acceleration of Anomalous Cosmic Rays in the heliosheath.     

Pickup Ions and Cosmic Rays from Dust in the Heliosphere

The combination of recent observational and theoretical work has completed the catalog of the sources of heliospheric Pickup Ions (PUIs). These PUIs are the seed population for Anomalous Cosmic Rays (ACRs), which are accelerated to high energies at or beyond the Termination Shock (TS). For elements with high First Ionization Potentials (high-FIP atoms: e.g., H, He, Ne, etc.), the dominant source of PUIs and ACRs is from neutral atoms that drift into the heliosphere from the Local Interstellar Medium (LISM) and, prior to ionization, are influenced primarily by solar gravitation and radiation pressure (for H). After ionization, these interstellar ions are pickup up by the solar wind, swept out, and are either accelerated near the TS or beyond it. Elements with low first ionization potentials (low-FIP atoms: e.g., C, Si, Mg, Fe, etc.) are also observed as PUIs by Ulysses and as ACRs by Wind and Voyager. But the low-FIP composition of this additional component reveals a very different origin. Low-FIP interstellar atoms are predominantly ionized in the LISM and therefore excluded from the heliosphere by the solar wind. Remarkably, a low-FIP component of PUIs was hypothesized by Banks (J. Geophys. Res. 76, 4341, 1971) over twenty years prior to its direct detection by Ulysses/SWICS (Geiss et al., J. Geophys. Res. 100(23), 373, 1995) The leading concept for the generation of Inner Source PUIs involves an effective recycling of solar wind on grains near the Sun, as originally suggested by Banks. Voyager and Wind also observe low-FIP ACRs, and a grain-related source appears likely and necessary. Two concepts have been proposed to explain these low-FIP ACRs: the first concept involves the acceleration of the Inner Source of PUIs, and the second involves a so-called Outer Source of PUIs generated from solar wind interaction with the large population of grains in the Kuiper Belt. We review here the observational and theoretical work over the last decade that shows how solar wind and heliospheric grains interact to produce pickup ions, and, in turn, anomalous cosmic rays. The inner and outer sources of pickup ions and anomalous cosmic rays exemplify dusty plasma interactions that are fundamental throughout the cosmos for the production of energetic particles and the formation of stellar systems.