The role of repair in the survival of mammalian cells from heavy ion irradiation: approximation to the ideal case of target theory.

Theories of cellular radiation sensitivity that preclude a significant role for cellular repair processes in the final biological expression of cellular damage induced by ionizing radiation are unsound. Experiments are discussed here in which the cell-cycle dependency of the repair deficiency of the S/S variant, of the L5178Y murine leukemic lymphoblast was examined by treatment with the heavy ions, 20Ne, 28Si, 40Ar, 56Fe and 93Nb. Evidence from those studies, which will be described in detail elsewhere, provide support for the notion that as the linear energy transfer (LET infinity) of the incident radiation increases the ability of the S/S cell to repair radiation damage decreases until effectively it is eliminated around 500 keV/micrometer. In the region of the latter LET infinity value, the behavior of the S/S cell approximates the ideal case of target theory where post-irradiation metabolism (repair) does not influence cell survival. The expression of this phenomenon among different cell types and tissues will depend upon the actual repair systems involved and other considerations.     

Fiber-optic gyros and quartz accelerometers for motion control

In article the opportunity of use strapdown inertial navigation system (SINS) on the base of fiber-optic gyroscopes and quartz accelerometers corrected from star sensors and satellite navigation equipment (SNE) for perspective interplanetary spacecrafts motion control on phases of interplanetary trajectory insertion, trajectory correction, and braking during transition to Mars orbit is investigated. Results of onboard control complex accuracy characteristics estimation are presented at the given dynamic spacecraft scheme which is taking into account the liquid oscillations in tanks and structure elements elasticity. At modelling the errors of measuring devices installation, errors of SINS initial alignment and instrumental errors of SINS sensitive elements, variation of control engines parameters were taken into account. The structure of the developed complex of imitation modelling of interplanetary spacecraft controlled motion is resulted. Estimations of active flight legs realization accuracy were received by a method of statistical modelling of spacecraft controlled motion     

Heat balance of the ionosphere: Implications for the international reference ionosphere

Theoretical considerations can be helpful tools in modelling ionospheric parameters in regions and for times where not enough experimental data are available. Our study asks whether results of heat balance calculations should be introduced to supplement the data base for the International Reference Ionosphere (IRI). We discuss the present status of our theoretical understanding and examine the influence of the following unresolved or neglected terms: (1) electron heating rate, (2) electron cooling by fine structure excitation of atomic oxygen, and (3) height-dependent Coulomb Logarithm. The ambiguity introduced by (1)–(3) leads up to 30% uncertainty in the electron temperature of the lower thermosphere. The electron temperature in the upper ionosphere is largely determined by heat conduction from above and depends critically on the conditions assumed at the boundary between ionosphere and plasmasphere.     

Mean winds of the mesosphere and lower thermosphere (60–110 km): A global distribution from radar systems (MF,Meteor, VHF)

During the last decade a large number of radars (～12) have been developed, which have produced substantial quantities of tidally-corrected mean winds data. The distribution of the radars is not global, but many areas are well covered: the Americas with Poker Flat (65°N), Saskatoon (52°N), Durham (43°N), Atlanta (34°N), Puerto Rico (18°N); Europe with Kiruna (68°), Garchy (47°N) and Monpazier (44°N); and Oceania with Christchurch (44°S), Adelaide (35°S), Townsville (20°S), and Kyoto (35°N). Zonal and meridional wind height-time cross-sections from $\text{60}\text{80}$ km (MF/Meteor Radar) to ～110 km have been prepared for the last 5–6 years. They are compared with cross-sections from CIRA-72 for zonal winds, and Groves (1969) for meridional winds.It is shown that while CIRA-72 is still a useful model for many purposes, significant differences exist between it and the new radar data. The latter demonstrate important seasonal, latitudinal, longitudinal and hemispheric variations. The new meridional cross-sections are of great value. The common features with Groves (1969) are the equatorward cells in summer near 85 km; however their strength (～10 ms^?1) and size are less. Systematic and somewhat different variations emerge at higher (?52°N) and middle (35–44°) latitudes.     

A new polyethylene balloon film

After over twenty years there is a new film introduced in the United States for fabricating scientific balloons. The film was developed by Raven and is designated Astrofilm.The film is a result of a critical selection of both the resin and extruding parameters. The film's physical properties and results of a test flight are reported. Also reported are a proposed design modification and failure analysis.     

Synthetic Environments for Simulated Missions

Synthetic environments offer Space Flight projects an opportunity to perform rapid, comprehensive, and rigorous modeling of the critical elements of a mission in order to compute quantitative measures of design performance, associated risk, and actual mission utility value. Significantly, these studies can be performed early in the mission cycle. These synthetic terrains are generated on parallel, high-performance computers and served to remote simulations at near-interactive speeds. The terrain creation uses a realistic sequence of physical phenomena such as cratering and dusting with parametric control of features such as surface roughness and rock density. Terrain resolution may be arbitrary but typically ranges from 0.01 to 10 meters. The terrain server has been used for two rover simulations, one using the actual Sojourner autonomy flight code, and the other a more general algorithm. Monte Carlo studies of rover designs interacting with synthetic environments were executed in parallel to quickly compute performance statistics and risk estimates.     

SPOT-2 and TOPEX/Poseidon precise orbit determination from DORIS doppler tracking

The French earth observation satellite SPOT-2 has served as a testbed for precise orbit determination from DORIS doppler tracking in anticipation of the TOPEX/Poseidon mission. Using the most up-to-data gravity field model, JGM-2, a radial orbit accuracy of about 2–9 cm was achieved, with an rms of fit of the tracking data of about 0.64 mm/s. Furthermore, it was found that the coordinates of the ground stations can be determined with an accuracy of the order of 2–5 cm after removal of common rotations, and translations.

Using a slightly different model for atmospheric drag, but the same gravity model, precise orbits of TOPEX/Poseidon from DORIS tracking data were determined with a radial orbit accuracy of the order of 4–5 cm, which is far within the 13 cm mission requirement. This conclusion is based on the analysis of 1-day overlap of successive 11-day orbits, and the comparisons with orbits computed from satellite laser tracking (SLR) and from the combination of SLR and DORIS tracking. Results indicate a consistency between the different orbits of 1–4 cm, 4–20 cm, and 6–13 cm in the radial, cross-track, and along-track directions, respectively. The residual rms is about 4–5 cm for SLR data and 0.56 mm/s for DORIS tracking. These numbers are roughly twice as large as the system noise levels, reflecting the fact that there are still some modeling errors left.     

Issues of exploration: human health and wellbeing during a mission to Mars.

Today, the tools are in our hands to enable us to travel away from our home planet and become citizens of the solar system. Even now, we are seriously beginning to develop the robust infrastructure that will make the 21st century the Century of Space Travel. But this bold step must be taken with due concern for the health, safety and wellbeing of future space explorers. Our long experience with space biomedical research convinces us that, if we are to deal effectively with the medical and biomedical issues of exploration, then dramatic and bold steps are also necessary in this field. We can no longer treat the human body as if it were composed of muscles, bones, heart and brain acting independently. Instead, we must lead the effort to develop a fully integrated view of the body, with all parts connected and fully interacting in a realistic way. This paper will present the status of current (2000) plans by the National Space Biomedical Research Institute to initiate research in this area of integrative physiology and medicine. Specifically, three example projects are discussed as potential stepping stones towards the ultimate goal of producing a digital human. These projects relate to developing a functional model of the human musculoskeletal system and the heart.     

Gravisensing: ionic responses, cytoskeleton and amyloplast behavior.

In Zea mays L., changes in orientation of stems are perceived by the pulvinal tissue, which responds to the stimulus by differential growth resulting in upward bending of the stem. Gravity is perceived in the bundle sheath cells, which contain amyloplasts that sediment to the new cell base when a change in the gravity vector occurs. The mechanism by which the mechanical signal is transduced into a physiological response is so far unknown for any gravity perceiving tissue. It is hypothesized that this involves interactions of amyloplasts with the plasma membrane and/or ER via cytoskeletal elements. To gain further insights into this process we monitored amyloplast movements in response to gravistimulation. In a pharmacological approach we investigated how the dynamics of plastid sedimentation are affected by actin and microtubule (MT) disrupting drugs. Dark grown caulonemal filaments of the moss Physcomitrella patens respond to gravity vector changes with a reorientation of tip growth away from the gravity vector. MT distributions in tip cells were monitored over time and MTs were seen to accumulate preferentially on the lower flank of the tip 30 min after a 90 degree turn. Using a self-referencing Ca2+ selective ion probe, we found that growing caulonemal filaments exhibit a Ca2+ influx at the apical dome, similar to that reported previously for other tip growing cells. However, in gravistimulated Physcomitrella filaments the region of Ca2+ influx is not confined to the apex, but extends about 60 micrometers along the upper side of the filament. Our results indicate an asymmetry in the Ca2+ flux pattern between the upper and side of the filament suggesting differential activation of Ca2+ permeable channels at the plasma membrane.     

A space radiation transport method development.

Improved spacecraft shield design requires early entry of radiation constraints into the design process to maximize performance and minimize costs. As a result, we have been investigating high-speed computational procedures to allow shield analysis from the preliminary design concepts to the final design. In particular, we will discuss the progress towards a full three-dimensional and computationally efficient deterministic code for which the current HZETRN evaluates the lowest-order asymptotic term. HZETRN is the first deterministic solution to the Boltzmann equation allowing field mapping within the International Space Station (ISS) in tens of minutes using standard finite element method (FEM) geometry common to engineering design practice enabling development of integrated multidisciplinary design optimization methods. A single ray trace in ISS FEM geometry requires 14 ms and severely limits application of Monte Carlo methods to such engineering models. A potential means of improving the Monte Carlo efficiency in coupling to spacecraft geometry is given in terms of re-configurable computing and could be utilized in the final design as verification of the deterministic method optimized design.