Dose equivalent, absorbed dose and charge spectrum investigation in low Earth orbit.

Particle intensity, dose equivalent and absorbed dose have been measured on board the space shuttle Endeavour during STS-108 in December 2001 by Dublin Institute for Advanced Studies (DIAS). The dose estimates are based on very accurate measurements of recoils produced in CR-39 by cosmic ray primary and secondary protons and heavier nuclei and by secondary neutrons. The corresponding LET spectra were used to determine dose equivalent and absorbed dose values. Estimates of the total flux of Z > or = 2 nuclei have been undertaken and a preliminary charge spectrum was measured. Some comparisons are made with preliminary data obtained on STS-105 (ISS Expedition) and other missions using CR-39 detectors.     

Large-size space laboratory for biological orbit experiments.

The study of space factors on living systems has great interest and long-term experiments during orbital flight will be important tool for increasing our knowledge. Realization of such experiments is limited by constraints of modern space stations. A new technology of large-size space laboratory for biological experiments has been developed on the basis of polymerization techniques. Using this technique there are no limits of form and size of laboratory for a space station that will permit long term experiments on Earth orbit with plants and animals in sufficient volume for creation of closed self-regulating ecological systems. The technology is based on experiments of the behavior of polymer materials in simulated free space conditions during the reaction of polymerization. The influences of space vacuum, sharp temperature changes and space plasma generated by galactic rays and Sun irradiation on chemical reaction were evaluated in their impact on liquid organic materials in laboratory conditions. The results of our study shows, that the chemical reaction is sensitive to such space factors. But we believe that the technology of polymerization could be used for the creation of space biological laboratories in Earth orbit in the near future.     

Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation.

Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process.     

Scanning, Tracking, and Mapping State Variable Estimation Algorithms

Recursive state equation estimation algorithms are derived to determine optimal estimation error covariance and state estimate for a linear dynamic system, driven by time-varying and positionverying (or angle-varying) functions whose a priori covariance are described. Retracing the same trajectory with the system measuring device causes the position varying function to repeat and can significantly reduce estimation errors. Applications for these algorithms include improving accuracy of a position dependent quantity to be mapped, or recursively processing radar or sonar data from repeating scans over the same area. Three types of return path patterns are considered: 1) multiple independent returns, 2) reverse returns, and 3) cyclical returns.     

Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons.

Two thiophosphoroate compounds WR-2721 and WR-151327 were assessed for their ability to modify the deleterious effects (life shortening and carcinogenesis) of fission-spectrum neutrons (kerma-weighted mean energy of 0.85 MeV) or gamma rays on B6CF1 hybrid mice. Male and female mice, 200 of each sex per experimental group, were irradiated individually at 110 days of age. Radioprotectors (400 mg/kg of WR-2721 or 580 mg/kg of WR-151327) were administered intraperitoneally 30 min prior to irradiation. Neutron doses were 10 cGy or 40 cGy and gamma ray doses were 206 cGy or 417 cGy. Animals were housed five to a cage; cage locations in the holding rooms were randomized by computer. Animals were checked daily and all deceased animals were necropsied. WR-2721 afforded protection against both neutron- and gamma-ray-induced carcinogenesis and subsequent life shortening. Cumulative survival curves for unirradiated mice of either sex were unaffectecd by protectors. WR-2721 protected irradiated groups against life shortening by approximately 10 cGy of neutrons or 100 cGy of gamma rays. WR-151327 was as effective as WR-2721 against neutron irradiation.     

Aiming at a 1-cm Orbit for Low Earth Orbiters: Reduced-Dynamic and Kinematic Precise Orbit Determination

The computation of high-accuracy orbits is a prerequisite for the success of Low Earth Orbiter (LEO) missions such as CHAMP, GRACE and GOCE. The mission objectives of these satellites cannot be reached without computing orbits with an accuracy at the few cm level. Such a level of accuracy might be achieved with the techniques of reduced-dynamic and kinematic precise orbit determination (POD) assuming continuous Satellite-to-Satellite Tracking (SST) by the Global Positioning System (GPS). Both techniques have reached a high level of maturity and have been successfully applied to missions in the past, for example to TOPEX/POSEIDON (T/P), leading to (sub-)decimeter orbit accuracy. New LEO gravity missions are (to be) equipped with advanced GPS receivers promising to provide very high quality SST observations thereby opening the possibility for computing cm-level accuracy orbits. The computation of orbits at this accuracy level does not only require high-quality GPS receivers, but also advanced and demanding observation preprocessing and correction algorithms. Moreover, sophisticated parameter estimation schemes need to be adapted and extended to allow the computation of such orbits. Finally, reliable methods need to be employed for assessing the orbit quality and providing feedback to the different processing steps in the orbit computation process. This revised version was published online in August 2006 with corrections to the Cover Date.     

Safety testing of lithium ion batteries for navy devices

Lithium ion battery technology is being introduced into power supplies used by our armed forces for a variety of applications. In many cases, the same cells and design parameters that support commercial battery packs are being used in military battery packs. This approach is expected to result in a major decrease in the total life cycle cost of the equipment these batteries support. On June 13, 1991, NAVSEA issued INST9310.1B1, which states that all lithium battery powered equipment must undergo safety evaluation and approval prior to fleet use. This safety program governs a process whereby approvals are issued for lithium batteries to be used in specific equipment on ground facilities, surface combatants, air combatants, and/or submarines. The Naval Ordnance Safety and Security Activity (NOSSA) manages the program. The chief technical advisors are Code 644 at NSWC Carderock Division and Code 609A at NSWC Crane Division. This paper describes three battery designs that incorporate lithium ion technology, and the results of battery safety tests conducted in accordance with navy requirements.     

Robust Kalman filter design for predictive wind shear detection

Severe low-altitude wind shear is a threat to aviation safety. Newly developed airborne sensors measure the radial component of wind along a line directly in front of an aircraft. The authors use optimal estimation theory to define a detection algorithm to warn of hazardous wind shear from these sensors. To achieve robustness, a wind shear detection algorithm must distinguish threatening wind shear from less hazardous gustiness, despite variations in wind shear structure. Statistical analysis methods to refine wind shear detection algorithm robustness are presented. Computational methods predict the ability to warn of severe wind shear and avoid false warning. Comparative capability of the detection algorithm as a function of its design parameters is determined, identifying designs that provide robust detection of severe wind shear     

A study on thin walled intersecting spheres

Intersecting spheres are useful in the design of pressure vessels for weight limited situations as in the case of space or ocean applications. This paper treats the general problem of N intersecting spheres demonstrating that mass reduction can be achieved in relation to the single sphere that encloses the same internal volume. It is shown that this reduction approaches asymptotically the value of 39.5%.