Soft X-ray characteristics of white dwarfs observed by EXOSAT

EXOSAT has observed 19 hot white dwarfs with alleged strong soft X-ray emission. Positive detection of a large fraction of this sample was obtained, among these practically all hot DA dwarfs. High-resolution spectral data, acquired with the 500 1/mm grating spectrometer, indicates no traces of He in the atmosphere of HZ43, i.e. n(He)/n(H) ? 10^?5 at a photospheric temperature of 60000 K (log g = 8). In contrast, the hot DA1 dwarf Feige 24 shows the presence of an appreciable He-abundance (n(He)/n(H) ? 10^?3); however no simple homogeneously mixed H/He atmosphere can explain the observed spectral shape.     

A new model of the ion composition at 75 to 1000 km for IRI

Ion composition of the ionosphere is an important parameter of any ionospheric model. The International Reference Ionosphere-1979 includes a program for the relative ion composition computation. The program was constructed on the basis of the Danilov and Semenov /1/ empirical model, which averaged 42 rocket measurements of the ion composition at middle latitudes below 200 km, on “AEROS” satellite measurements, and on Taylor's data /2/ above that altitude.     

SAMBO-GEOS: On three-dimensional substorm dynamics — A case study for 4 March 1979

For investigations of the isolated magnetospheric substorm the ground-based and satellite geophysical data are discussed. The active phase of the substorm has two parts: an active-convective phase and a classical active phase. The analysed data show that the breakup of the substorm takes place at closed and not very much stretched magnetic field lines.     

Neoplastic cell transformation by high-LET radiation: molecular mechanisms.

Experimental data on molecular mechanisms are essential for understanding the bioeffects of radiation and for developing biophysical models, which can help in determining the shape of dose-response curves at very low doses, e.g., doses less than 1 cGy. Although it has been shown that ionizing radiation can cause neoplastic cell transformation directly, that high-LET heavy ions in general can be more effective than photons in transforming cells, and that the radiogenic cell transformation is a multi-step process [correction of processes], we know very little about the molecular nature of lesions important for cell transformation, the relationship between lethal and transformational damages, and the evolution of initial damages into final chromosomal aberrations which alter the growth control of cells. Using cultured mouse embryo cells (C3H10T1/2) as a model system, we have collected quantitative data on dose-response curves for heavy ions with various charges and energies. An analysis of these quantitative data suggested that two DNA breaks formed within 80 angstroms may cause cell transformation and that two DNA breaks formed within 20 angstroms may be lethal. Through studies with restriction enzymes which produce DNA damages at specific sites, we have found that DNA double strand breaks, including both blunt- and cohesive-ended breaks, can cause cell transformation in vitro. These results indicate that DNA double strand breaks can be important primary lesions for radiogenic cell transformation and that blunt-ended double strand breaks can form lethal as well as transformational damages due to misrepair or incomplete repair in the cell. The RBE-LET relationship is similar for HGPRT gene mutation, chromosomal deletion, and cell transformation, suggesting common lesions may be involved in these radiation effects. The high RBE of high-LET radiation for cell killing and neoplastic cell transformation is most likely related to its effectiveness in producing DNA double strand breaks in mammalian cells. At present the role of oncogenes in radiation cell transformation is unclear.     

Software intensive systems safety analysis

Two important elements in the avionics suite of modern aircraft are: the flight control system (FCS) and the flight management system (FMS). The FCS provides the capability to stabilize and control the aircraft, while the FMS is responsible for flight planning and navigation. A clear trend in the aerospace industry is to place greater reliance on software systems, and many FCS and FMS subsystems are implemented primarily in software. For example, within the FCS is the flight guidance system (FGS) that generates roll and pitch guidance commands. Similarly, within the FMS is the vertical navigation (VNAV) function that acts like a third crew member in the cockpit, ordering mode change requests and resetting target altitude values to enable the aircraft to track the vertical flight plan. We have developed formal, executable models of the requirements for the mode logic of a FGS and for portions of the VNAV functionality. We have also conducted a comprehensive software safety analysis on the FGS mode logic model, and are completing the analysis of the VNAV model. This analysis uses as its starting point several "traditional" safety analysis techniques such as a functional hazard assessment (FHA), a fault tree analysis (FTA), and a failure mode effects analysis (FMEA). However, we are also using formal methods techniques known as model checking and theorem proving to verify the presence of safety properties in the model. This paper summarizes the (now completed) safety analysis that was performed on the FGS model, and highlights the similarities and differences with the (still on-going) safety analysis of the FMS model. In particular, we summarize progress made to date in the use of formal methods to verify the presence of the required safety properties in the models themselves.     

Tissue responses to low protracted doses of high LET radiations or photons: early and late damage relevant to radio-protective countermeasures.

Early and late murine tissue responses to single or fractionated low doses of heavy charged particles, fission-spectrum neutrons or gamma rays are considered. Damage to the hematopoietic system is emphasized, but results on acute lethality, host response to challenge with transplanted leukemia cells and life-shortening are presented. Low dose rates per fraction were used in some neutron experiments. Split-dose lethality studies (LD 50/30) with fission neutrons indicated greater accumulation of injury during a 9 fraction course (over 17 days) than was the case for gamma-radiation. When total doses of 96 or 247 cGy of neutrons or gamma rays were given as a single dose or in 9 fractions, a significant sparing effect on femur CFU-S depression was observed for both radiation qualities during the first 11 days, but there was not an earlier return to normal with dose fractionation. During the 9 fraction sequence, a significant sparing effect of low dose rate on CFU-S depression was observed in both neutron and gamma-irradiated mice. CFU-S content at the end of the fractionation sequence did not correlate with measured LD 50/30. Sustained depression of femur and spleen CFU-S and a significant thrombocytopenia were observed when a total neutron dose of 240 cGy was given in 72 fractions over 24 weeks at low dose rates. The temporal aspects of CFU-S repopulation were different after a single versus fractionated neutron doses. The sustained reduction in the size of the CFU-S population was accompanied by an increase in the fraction in DNA synthesis. The proliferation characteristics and effects of age were different for radial CFU-S population closely associated with bone, compared with the axial population that can be readily aspirated from the femur. In aged irradiated animals, the CFU-S proliferation/redistribution response to typhoid vaccine showed both an age and radiation effect. After high single doses of neutrons or gamma rays, a significant age- and radiation-related deficiency in host defense mechanisms was detected by a shorter mean survival time following challenge with transplantable leukemia cells. Comparison of dose-response curves for life shortening after irradiation with fission-spectrum neutrons or high energy silicon particles indicated high initial slopes for both radiation qualities at low doses, but for higher doses of silicon, the effect per Gy decreased to a value similar to that for gamma rays. The two component life-shortening curve for silicon particles has implications for the potential efficacy of radioprotectants. Recent studies on protection against early and late effects by aminothiols, prostaglandins, and other compounds are discussed.     

Aeronautical use of semiconductor lasers for short optical pulses

In this paper, we investigate the feasible schemes to generate periodic optical pulses of width between several picoseconds (ps) and tens ps. Gain-switched semiconductor laser diodes are shown to be more suitable for avionics applications than mode-locked laser diodes. In the experiment, we use a low-cost Fabry-Perot laser diode to generate short optical pulse streams. A simple optical injection-locking scheme is then used to reduce the timing jitter and frequency chirp in such laser diodes, which in turn can improve the transmission performance of the generated optical pulses. It is expected that the use of gain-switched semiconductor lasers can meet the requirement of high-speed airborne communication networks or ground supporting systems at airports. Moreover, we discuss the possibility of using the pulsed semiconductor lasers to generate millimetre-wave (mm-wave) signals for future applications to airborne high-resolution, mm-wave radars.     

Biological UV dosimeters in simulated space conditions.

Polycrystalline uracil thin layers participate in the phage and uracil response (PUR) experiment, assigned to the biological dosimetry of the extraterrestrial solar radiation on the International Space Station (ISS). In ground based experiments (experiment verification tests), the following space parameters were simulated and studied: temperature, vacuum and short wavelength UV (UV-C, down to 200 nm) radiation. The closed uracil samples proved to be vacuum-tight for 7 days. In the tested temperature range (from -20 to +40 degrees C) the uracil samples are stable. The kinetic of dimer formation (dimerization) and reversion (monomerization) of uracil dimers due to short wavelength UV radiation was detected, the monomerization efficiency of the polychromatic deuterium lamp is higher than that of the germicidal lamp. A mathematical model describing the kinetic of monomerization-dimerization was constructed. Under the influence of UV radiation the dimerization-monomerization reactions occur simultaneously, thus the additivity law of the effect of the various wavelengths is not applicable.     

Biological effects due to weak magnetic field on plants.

Throughout the evolution process, Earth's magnetic field (MF, about 50 microT) was a natural component of the environment for living organisms. Biological objects, flying on planned long-term interplanetary missions, would experience much weaker magnetic fields, since galactic MF is known to be 0.1-1 nT. However, the role of weak magnetic fields and their influence on functioning of biological organisms are still insufficiently understood, and is actively studied. Numerous experiments with seedlings of different plant species placed in weak magnetic field have shown that the growth of their primary roots is inhibited during early germination stages in comparison with control. The proliferative activity and cell reproduction in meristem of plant roots are reduced in weak magnetic field. Cell reproductive cycle slows down due to the expansion of G1 phase in many plant species (and of G2 phase in flax and lentil roots), while other phases of cell cycle remain relatively stable. In plant cells exposed to weak magnetic field, the functional activity of genome at early pre-replicate period is shown to decrease. Weak magnetic field causes intensification of protein synthesis and disintegration in plant roots. At ultrastructural level, changes in distribution of condensed chromatin and nucleolus compactization in nuclei, noticeable accumulation of lipid bodies, development of a lytic compartment (vacuoles, cytosegresomes and paramural bodies), and reduction of phytoferritin in plastids in meristem cells were observed in pea roots exposed to weak magnetic field. Mitochondria were found to be very sensitive to weak magnetic field: their size and relative volume in cells increase, matrix becomes electron-transparent, and cristae reduce. Cytochemical studies indicate that cells of plant roots exposed to weak magnetic field show Ca2+ over-saturation in all organelles and in cytoplasm unlike the control ones. The data presented suggest that prolonged exposures of plants to weak magnetic field may cause different biological effects at the cellular, tissue and organ levels. They may be functionally related to systems that regulate plant metabolism including the intracellular Ca2+ homeostasis. However, our understanding of very complex fundamental mechanisms and sites of interactions between weak magnetic fields and biological systems is still incomplete and still deserve strong research efforts.     

The MELISSA pilot plant facility as as integration test-bed for advanced life support systems.

The different advances in the Micro Ecological Life Support System Alternative project (MELISSA), fostered and coordinated by the European Space Agency, as well as in other associated technologies, are integrated and demonstrated in the MELISSA Pilot Plant laboratory. During the first period of operation, the definition of the different compartments at an individual basis has been achieved, and the complete facility is being re-designed to face a new period of integration of all these compartments. The final objective is to demonstrate the potentiality of biological systems such as MELISSA as life support systems. The facility will also serve as a test bed to study the robustness and stability of the continuous operation of a complex biological system. This includes testing of the associated instrumentation and control for a safe operation, characterization of the chemical and microbial safety of the system, as well as tracking the genetic stability of the microbial strains used. The new period is envisaged as a contribution to the further development of more complete biological life support systems for long-term manned missions, that should be better defined from the knowledge to be gained from this integration phase. This contribution summarizes the current status of the Pilot Plant and the planned steps for the new period.