Computerized Medical Devices: Trends, Problems, and Safety

Virtually all of the medical devices utilizing electronics will contain a micro or minicomputer by 1990. These devices accounted for $7 billion in U.S. sales in 1984. Their capabilities can provide the means for new or greatly improved medical procedures, and ensure greater patient safety. However, these benefits can easily be compromised if ``computer safety' is not practiced in the design, manufacturing, testing and clinical use of these devices. Along with a trend to wider usage, the number of recalls of medical devices due to computer-related problems has approximately doubled in the last five years. ``Computer-caused' problems are often not recognized or reported as such, resulting in an underestimation of the prevalence of this type of problem. Our study of technical factors causing problems in computerized devices revealed that software quality assurance (SQA), the quality of the ac power, and electromagnetic interference are primary factors. Selected design and QA techniques that are well-known in military-aerospace industries can be used to prevent the most prevalent problems occurring in computerized medical devices, without significantly affecting overall device manufacturing costs.     

Organic chemistry in Titan's atmosphere: new data from laboratory simulations at low temperature.

Many experiments have already been carried out to simulate organic chemistry on Titan, the largest satellite of Saturn. They can provide fruitful information on the nature of minor organic constituents likely to be present in Titan's atmosphere, both in gas and aerosol phases. Indeed, all the organic compounds but one already detected in Titan's atmosphere have been identified in simulation experiments. The exception, C4N2, as well as other compounds expected in Titan from theoretical modeling, such as other N-organics, and polyynes, first of all C6H2, have never been detected in experimental simulation thus far. All these compounds are thermally unstable, and the temperature conditions used during the simulation experiments were not appropriate. We have recently started a new program of simulation experiments with temperature conditions close to that of Titan's environment. It also uses dedicated analytical techniques and procedures compatible with the analysis of organics only stable at low temperatures, as well solid products of low stability in the presence of O2 and H2O. Spark discharge of N2-CH4 gas mixtures was carried out at low temperature in the range 100-150 K. Products were analysed by FTIR, GC and GC-MS techniques. GC-peaks were identified by their mass spectrum, and, in most cases, by comparison of the retention time and mass spectrum with standard ones. We report here the first detection in Titan simulation experiments of C6H2 and HC5N. Their abundance is a few percent relative to C4H2 and HC3N, respectively. Preliminary data on the solid products indicate an elemental composition corresponding to (H11C11N)n. These results open new prospects in the modeling of Titan's haze making.     

Delta-electron emission in fast heavy ion atom collisions.

Biological damages such as mutations, chromosomal aberrations etc. are a consequence of biochemical changes mostly in the DNA. With ionizing radiation, these chemical changes are due to primary ionization events and secondary ionization effects caused by the primarily produced electrons. Differences in the biological response of densely ionizing radiation, like heavy charged particles, in comparison to sparsely ionizing radiation, such as X- or gamma-rays, are mainly due to the differences in the production of the so called delta-electrons. Therefore, the emission process of electrons i.e. the cross section for the primary ionization event as well as the energy and angular distribution of the emitted electrons should be understood in detail. The delta-electron emission processes occuring in fast heavy ion atom collisions are explained qualitatively. The different spectral structures of electron emission arising from either the target or the projectile are explained in terms of simple models of the kinetics of momentum transfer induced by the COULOMB forces. In collisions of very heavy ions with matter, high nuclear COULOMB forces are created. These forces lead to a strong polarization of the electronic states of the participated electrons. The effects of this polarization are discussed.     

Protein crystal growth aboard the U.S. space shuttle flights STS-31 and STS-32.

The first microgravity protein crystal growth experiments were performed on Spacelab I by Littke and John. These experiments indicated that the space grown crystals, which were obtained using a liquid-liquid diffusion system, were larger than crystals obtained by the same experimental system on earth. Subsequent experiments were performed by other investigators on a series of space shuttle missions from 1985 through 1990. The results from two of these shuttle flights (STS-26 and STS-29) have been described previously. The results from these missions indicated that the microgravity grown crystals for a number of different proteins were larger, displayed more uniform morphologies, and yielded diffraction data to significantly higher resolutions than the best crystals of these proteins grown on earth. This paper presents the results obtained from shuttle flight STS-32 (flown in January, 1990) and preliminary results from the most recent shuttle flight, STS-31 (flown in April, 1990).     

Precision orbit determination for TOPEX/Poseidon using TDRSS doppler tracking data

Precision orbit determination on the TOPEX/Poseidon (T/P) altimeter satellite is now being routinely achieved with sub-5cm radial and sub-15 cm total positioning accuracy using state-of-the-art modeling with precision tracking provided by a combination of: (a) global Satellite Laser Ranging (SLR) and Doppler Orbitography and Radiopositioning Integrated by Satellite (DORIS), or (b) the Global Positioning System (GPS) Constellation which provides pseudo-range and carrier phase observations. The geostationary Tracking and Data Relay Satellite System (TDRSS) satellites are providing the operational tracking and communication support for this mission. The TDRSS Doppler data are of high precision (0.3 mm/s nominal noise levels). Unlike other satellite missions supported operationally by TDRSS, T/P has high quality independent tracking which enables absolute orbit accuracy assessments. In addition, the T/P satellite provides extensive geometry for positioning a satellite at geostationary altitude, and thus the TDRSS-T/P data provides an excellent means for determining the TDRS orbits. Arc lengths of 7 and 10 days with varying degrees of T/P spacecraft attitude complexity are studied. Sub-meter T/P total positioning error is achieved when using the TDRSS range-rate data, with radial orbit errors of 10.6 cm and 15.5 cm RMS for the two arcs studied. Current limitations in the TDRSS precision orbit determination capability include mismodeling of numerous TDRSS satellite-specific dynamic and electronic effects, and in the inadequate treatment of the propagation delay and bending arising from the wet troposphere and ionosphere.     

Cloud profiling radar for the CloudSat mission

The Cloud Profiling Radar (CPR) for the upcoming CloudSat Mission is a spaceborne 94-GHz nadir-looking radar that measures the power backscattered by clouds as a function of distance from the radar. This sensor is expected to provide cloud measurements at a 500-m vertical resolution and a 1.5 km horizontal resolution. CPR will operate in a short-pulse mode and will yield measurements at a minimum detectable sensitivity of -28 dBZ.     

The time delay of a solar grazing photon

Moving clocks and clocks in a gravitational field slow down, not due to the effects of special relativity nor to the space-time curvature of general relativity, but due only to the principle of equivalence and the conservation of energy. However, some might argue that there has been a further “test” of the effect of gravity on time, namely, the measurement of the time-delay of a round-trip, solar-grazing radar beacon performed by Shapiro in the 1960s. In this test, Shapiro bounced a radar pulse off Mars at superior conjunction (a feat in itself for the time), and compared the measured round-trip travel time of this pulse with the expected round-trip time of a signal traveling at c for the entire trip, as determined from highly accurate planetary ephemerides. Shapiro had predicted this time-delay long before being technologically able to make such a measurement. While general relativity can be used to correctly obtain the magnitude of this delay, it is not the only explanation. As earlier with the analysis of clocks in motion and of clocks in a gravitational field, this paper derives the same result without invoking the space-time curvature of general relativity     

Alice: The rosetta Ultraviolet Imaging Spectrograph

We describe the design, performance and scientific objectives of the NASA-funded ALICE instrument aboard the ESA Rosetta asteroid flyby/comet rendezvous mission. ALICE is a lightweight, low-power, and low-cost imaging spectrograph optimized for cometary far-ultraviolet (FUV) spectroscopy. It will be the first UV spectrograph to study a comet at close range. It is designed to obtain spatially-resolved spectra of Rosetta mission targets in the 700–2050 Å spectral band with a spectral resolution between 8 Å and 12 Å for extended sources that fill its ～0.05^ × 6.0^ field-of-view. ALICE employs an off-axis telescope feeding a 0.15-m normal incidence Rowland circle spectrograph with a toroidal concave holographic reflection grating. The microchannel plate detector utilizes dual solar-blind opaque photocathodes (KBr and CsI) and employs a two-dimensional delay-line readout array. The instrument is controlled by an internal microprocessor. During the prime Rosetta mission, ALICE will characterize comet 67P/Churyumov-Gerasimenko's coma, its nucleus, and nucleus/coma coupling; during cruise to the comet, ALICE will make observations of the mission's two asteroid flyby targets and of Mars, its moons, and of Earth's moon. ALICE has already successfully completed the in-flight commissioning phase and is operating well in flight. It has been characterized in flight with stellar flux calibrations, observations of the Moon during the first Earth fly-by, and observations of comet C/2002 T7 (LINEAR) in 2004 and comet 9P/Tempel 1 during the 2005 Deep Impact comet-collision observing campaign.