Computerized Medical Devices: Trends, Problems, and Safety

Virtually all of the medical devices utilizing electronics will contain a micro or minicomputer by 1990. These devices accounted for $7 billion in U.S. sales in 1984. Their capabilities can provide the means for new or greatly improved medical procedures, and ensure greater patient safety. However, these benefits can easily be compromised if ``computer safety' is not practiced in the design, manufacturing, testing and clinical use of these devices. Along with a trend to wider usage, the number of recalls of medical devices due to computer-related problems has approximately doubled in the last five years. ``Computer-caused' problems are often not recognized or reported as such, resulting in an underestimation of the prevalence of this type of problem. Our study of technical factors causing problems in computerized devices revealed that software quality assurance (SQA), the quality of the ac power, and electromagnetic interference are primary factors. Selected design and QA techniques that are well-known in military-aerospace industries can be used to prevent the most prevalent problems occurring in computerized medical devices, without significantly affecting overall device manufacturing costs.     

Organic chemistry in Titan's atmosphere: new data from laboratory simulations at low temperature.

Many experiments have already been carried out to simulate organic chemistry on Titan, the largest satellite of Saturn. They can provide fruitful information on the nature of minor organic constituents likely to be present in Titan's atmosphere, both in gas and aerosol phases. Indeed, all the organic compounds but one already detected in Titan's atmosphere have been identified in simulation experiments. The exception, C4N2, as well as other compounds expected in Titan from theoretical modeling, such as other N-organics, and polyynes, first of all C6H2, have never been detected in experimental simulation thus far. All these compounds are thermally unstable, and the temperature conditions used during the simulation experiments were not appropriate. We have recently started a new program of simulation experiments with temperature conditions close to that of Titan's environment. It also uses dedicated analytical techniques and procedures compatible with the analysis of organics only stable at low temperatures, as well solid products of low stability in the presence of O2 and H2O. Spark discharge of N2-CH4 gas mixtures was carried out at low temperature in the range 100-150 K. Products were analysed by FTIR, GC and GC-MS techniques. GC-peaks were identified by their mass spectrum, and, in most cases, by comparison of the retention time and mass spectrum with standard ones. We report here the first detection in Titan simulation experiments of C6H2 and HC5N. Their abundance is a few percent relative to C4H2 and HC3N, respectively. Preliminary data on the solid products indicate an elemental composition corresponding to (H11C11N)n. These results open new prospects in the modeling of Titan's haze making.     

Delta-electron emission in fast heavy ion atom collisions.

Biological damages such as mutations, chromosomal aberrations etc. are a consequence of biochemical changes mostly in the DNA. With ionizing radiation, these chemical changes are due to primary ionization events and secondary ionization effects caused by the primarily produced electrons. Differences in the biological response of densely ionizing radiation, like heavy charged particles, in comparison to sparsely ionizing radiation, such as X- or gamma-rays, are mainly due to the differences in the production of the so called delta-electrons. Therefore, the emission process of electrons i.e. the cross section for the primary ionization event as well as the energy and angular distribution of the emitted electrons should be understood in detail. The delta-electron emission processes occuring in fast heavy ion atom collisions are explained qualitatively. The different spectral structures of electron emission arising from either the target or the projectile are explained in terms of simple models of the kinetics of momentum transfer induced by the COULOMB forces. In collisions of very heavy ions with matter, high nuclear COULOMB forces are created. These forces lead to a strong polarization of the electronic states of the participated electrons. The effects of this polarization are discussed.     

Results from the Energetic Gamma-Ray Experiment Telescope (EGRET) on the Compton Observatory

The Energetic Gamma-Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory covers the high energy gamma ray energy range, approximately 30 MeV to 30 GeV, with a sensitivity considerably greater than earlier high energy gamma-ray satellites. Thus far, 4 pulsars have been detected and their properties measured, including in 3 cases the energy spectrum as a function of phase. The details of the galactic plane are being mapped and a spectra of the center region has been obtained in good agreement with that expected from cosmic ray interactions. The Magellanic clouds have been examined with the Large Magellanic Cloud having been detected at a level consistent with it having a cosmic ray density compatible with quasi-stable equilibrium. Sixteen Active Galactic Nuclei (AGN's) have been seen thus far with a high degree of certainty including 12 quasars and 4 BL Lac objects, but no Seyferts. Time variation has been detected in some of these AGN's.     

A multioutput LLC-type parallel resonant converter

When an LLC-type parallel resonant converter (LLC-PRC) operates above resonant frequency, the switching transistors can be turned off at zero voltage. Further study reveals that the LLC-PRC possesses the advantage of lower converter voltage gain as compared with the conventional PRC. Based on the analytic results derived, a complete set of design curves from which a systematic design procedure is developed is obtained. Experimental results from a 150-W, 150-kHz, multioutput LLC-type PRC power supply are presented     

Protein crystal growth aboard the U.S. space shuttle flights STS-31 and STS-32.

The first microgravity protein crystal growth experiments were performed on Spacelab I by Littke and John. These experiments indicated that the space grown crystals, which were obtained using a liquid-liquid diffusion system, were larger than crystals obtained by the same experimental system on earth. Subsequent experiments were performed by other investigators on a series of space shuttle missions from 1985 through 1990. The results from two of these shuttle flights (STS-26 and STS-29) have been described previously. The results from these missions indicated that the microgravity grown crystals for a number of different proteins were larger, displayed more uniform morphologies, and yielded diffraction data to significantly higher resolutions than the best crystals of these proteins grown on earth. This paper presents the results obtained from shuttle flight STS-32 (flown in January, 1990) and preliminary results from the most recent shuttle flight, STS-31 (flown in April, 1990).     

Expanding global access to civilian and commercial remote sensing data: implications and policy issues

Current and planned developments in the field of civilian and commercial satellite imagery promise a major expansion in international accessibility to remote sensing data and technologies. This paper addresses the implications of the expanding global access to land remote sensing data and their derived products. While atmospheric, meteorological, and oceanographic data is also widely available at cost or free of charge, it is land remote sensing - specifically the unique systems with high-resolution and frequent revisit times - that are of primary concern for international and regional security issues. Military and intelligence satellites are not addressed in this discussion of expansion due to their inherently controlled access, unless such systems also provide commercially available imagery or products (as is the case with some Russian systems).     

Algorithms for Improved, Heading Assisted, Maneuver Tracking

The evolution of the SSR mode S system makes it possible to receive airborne measurements at the ground station. The possibility of using data-linked heading measurements to assist present trackers to track maneuvering aircraft is investigated. The quality to be expected from heading measurements is investigated from available on-board recordings. Maneuver detection and false measurement rejection schemes are developed, and finally suitable maneuver tracking filters are constructed and evaluated.     

Precision orbit determination for TOPEX/Poseidon using TDRSS doppler tracking data

Precision orbit determination on the TOPEX/Poseidon (T/P) altimeter satellite is now being routinely achieved with sub-5cm radial and sub-15 cm total positioning accuracy using state-of-the-art modeling with precision tracking provided by a combination of: (a) global Satellite Laser Ranging (SLR) and Doppler Orbitography and Radiopositioning Integrated by Satellite (DORIS), or (b) the Global Positioning System (GPS) Constellation which provides pseudo-range and carrier phase observations. The geostationary Tracking and Data Relay Satellite System (TDRSS) satellites are providing the operational tracking and communication support for this mission. The TDRSS Doppler data are of high precision (0.3 mm/s nominal noise levels). Unlike other satellite missions supported operationally by TDRSS, T/P has high quality independent tracking which enables absolute orbit accuracy assessments. In addition, the T/P satellite provides extensive geometry for positioning a satellite at geostationary altitude, and thus the TDRSS-T/P data provides an excellent means for determining the TDRS orbits. Arc lengths of 7 and 10 days with varying degrees of T/P spacecraft attitude complexity are studied. Sub-meter T/P total positioning error is achieved when using the TDRSS range-rate data, with radial orbit errors of 10.6 cm and 15.5 cm RMS for the two arcs studied. Current limitations in the TDRSS precision orbit determination capability include mismodeling of numerous TDRSS satellite-specific dynamic and electronic effects, and in the inadequate treatment of the propagation delay and bending arising from the wet troposphere and ionosphere.