Single ion actions: the induction of micronuclei in V79 cells exposed to individual protons.

Understanding the effects of single-particles from conventional radiation biology experiments is problematic due to the stochastics of particle tracks. This complicates the determinations of risk associated with low doses. We have developed a charged particle microbeam, which allows individually counted particles to be delivered to precise cellular locations. The system is capable of delivering a single charged particle with > 99% efficiency. Of these particles 90% are delivered with a resolution of +/- 2 micrometers and 96% with a resolution of +/- 5 micrometers. We have carried out preliminary studies in Chinese hamster V79 cells to monitor the effectiveness of low energy protons at inducing cytological damage. We have used the micronucleus assay as a measure of predominantly lethal chromosome damage. The effects of a single 3.2 MeV proton delivered individually to cells could be measured, with less than 2% of the exposed cells producing micronuclei 24 hours later. The yield of micronuclei formation was essentially linear up to the highest dose (30 particles per cell nucleus) delivered. Ultimately, the ability to target particles to different parts of the cell nucleus may start to impact on models available for chromosome aberration formation and chromosomal Organisation and mechanisms underlying genomic instability.     

Optimum Position Estimation Using Multiple-Frequency Omega

The maximum-likelihood estimator of the line of position (LOP) resulting from K frequencies received from each of two Omega stations for high SNR is derived. The estimator takes advantage of interfrequency correlation of phase uncertainties by modeling them as resulting from phase velocity uncertainties which are jointly Gaussian with known covariance. The utilization of Omega for search and rescue systems is examined. For this application, the result of increasing the size of the unambiguous lanes of Omega by addition of a fourth frequency to the present three-frequency format is examined. The results of Monte Carlo simulation, performed for several easily implemented fourth frequencies, are presented. The simulation results illustrate the extent to which lane errors can be expected as a function of various fourth frequencies, phase velocity uncertainties, and SNR.     

拉压、扭转载荷下铸铝合金的亿周疲劳性能研究

应用超声疲劳试验机对铸铝合金2-AS5U3G-Y35在扭转和拉压循环载荷下进行了超高周疲劳性能测试.介绍了超声扭转疲劳试验装置的设计.应用35 Hz常规疲劳试验机和20 kHz的超声疲劳试验机完成应力比R=-1的拉压、扭转疲劳试验,进而研究不同载荷条件、加载频率对铸铝合金超高周疲劳性能的影响.S-N曲线显示,铝合金在105～1010疲劳周次间仍发生疲劳断裂,不存在疲劳极限.断口分析表明,在超高周循环拉压载荷下,疲劳裂纹常萌生于试样次表面材料内部缩孔.与循环拉压载荷下的疲劳断裂机理不同,在循环扭转载荷下疲劳裂纹主要萌生于试样表面,疲劳断裂面为一种典型的沿试样轴向45°的螺旋面,即沿最大主应力平面断裂.扭转疲劳断面清晰的剪切条带表明扭转疲劳断裂实质上是剪切断裂.     

Estimation and classification of FM signals using time frequency transforms

This work deals with electronic warfare: we have to process an intercepted radar-emitted signal assumed to be frequency-modulated (FM). A battery of parametric models being available, we face the two main problems: the parameter estimation, given a model, and the classification, given the battery. For the former, we propose the classical maximum likelihood estimator (MLE) and an original numerical scheme to reach it. For the latter, we construct a test based on the estimated variances cross-ratios. Both perform very efficiently with respect to (w.r.t.) the Cramer-Rao lower bound (CRLB) and the rate of correct classification, respectively, for low signal-to-noise ratios (SNRs).