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671.
M Durante T Kawata T Nakano S Yamada H Tsujii 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1998,22(12):1653-1662
We report measurements of chromosomal aberrations in peripheral blood lymphocytes from cancer patients undergoingradiotherapy treatment. Patients with cervix or esophageal cancer were treated with 10 MV X-rays produced at a LINAC accelerator, or high-energy carbon ions produced at the HIMAC accelerator at the National Institute for Radiological Sciences (NIRS) in Chiba. Blood samples were obtained before, during, and after the radiation treatment. Chromosomes were prematurely condensed by incubation in calyculin A. Aberrations in chromosomes 2 and 4 were scored after fluorescence in situ hybridization with whole-chromosome probes. Pre-treatment samples were exposed in vitro to X-rays, individual dose-response curves for the induction of chromosomal aberrations were determined, and used as calibration curves to calculate the effective whole-body dose absorbed during the treatment. This calculated dose, based on the calibration curve relative to the induction of reciprocal exchanges, has a sharp increase after the first few fractions of the treatment, then saturates at high doses. Although carbon ions are 2–3 times more effective than X-rays in tumor sterilization, the effective dose was similar to that of X-ray treatment. However, the frequency of complex-type chromosomal exchanges was much higher for patients treated with carbon ions than X-ray. 相似文献
672.
S.G. Anokhin 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2008
We present here new XMM-Newton observations of 3 relatively cool clusters at z ≈ 0.4, complemented by archival observations of 3 other clusters at similar redshift. We derived the M–T and R–T relations from the hydrostatic equation using an isothermal temperature distribution. 相似文献
673.
N Desai H Wu K George S R Gonda F A Cucinotta 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2004,34(6):1362-1367
Space flight results in the exposure of astronauts to a mixed field of radiation composed of energetic particles of varying energies, and biological indicators of space radiation exposure provides a better understanding of the associated long-term health risks. Current methods of biodosimetry have employed the use of cytogenetic analysis for biodosimetry, and more recently the advent of technological progression has led to advanced research in the use of genomic and proteomic expression profiling to simultaneously assess biomarkers of radiation exposure. We describe here the technical advantages of the Luminex(TM) 100 system relative to traditional methods and its potential as a tool to simultaneously profile multiple proteins induced by ionizing radiation. The development of such a bioassay would provide more relevant post-translational dynamics of stress response and will impart important implications in the advancement of space and other radiation contact monitoring. 相似文献
674.
Track segment association, fine-step IMM and initialization with Doppler for improved track performance 总被引:2,自引:0,他引:2
Yeom S.-W. Kirubarajan T. Bar-Shalom Y. 《IEEE transactions on aerospace and electronic systems》2004,40(1):293-309
In this work we present a new track segment association technique to improve track continuity in large-scale target tracking problems where track breakages are common. A representative airborne early warning (AEW) system scenario, which is a challenging environment due to highly maneuvering targets, close target formations, large measurement errors, long sampling intervals, and low detection probabilities, provides the motivation for the new technique. Previously, a tracker using the interacting multiple model (IMM) estimator combined with an assignment algorithm was shown to be more reliable than a conventional Kalman filter based approach in tracking similar targets but it still yielded track breakages due to the difficult environment. In order to combine the broken track segments and improve track continuity, a new track segment association algorithm using a discrete optimization approach is presented. Simulation results show that track segment association yields significant improvements in mean track life as well as in position, speed, and course rms errors. Also presented is a modified one-point initialization technique with range rate measurements, which are typically ignored by other initialization techniques, and a fine-step IMM estimator, which improves performance in the presence of long revisit intervals. Another aspect that is investigated is the benefit of "deep" (multiframe or N-dimensional, with N > 2) association, which is shown to yield significant benefit in reducing the number of false tracks. 相似文献
675.
T.K Hei C.Q Piao L.J Wu J.C Willey E.J Hall 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1998,22(12):1699-1707
Carcinogenesis is postulated to be a progressive multistage process characterized by an increase in genomic instability and clonal selection with each mutational event endowing a selective growth advantage. Genomic instability as manifested by the amplification of specific gene fragments is common among tumor and transformed cells. In the present study, immortalized human bronchial (BEP2D) cells were irradiated with graded doses of either 1GeV/nucleon 56Fe ions or 150 keV/μm alpha particles. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Tumorigenic cells showed neither ras mutations nor deletion in the p16 tumor suppressor gene. In contrast, they harbored mutations in the p53 gene and over-expressed cyclin D1. Genomic instability among transformed cells at various stage of the carcinogenic process was examined based on frequencies of PALA resistance. Incidence of genomic instability was highest among established tumor cell lines relative to transformed, non-tumorigenic and control cell lines. Treatment of BEP2D cells with a 4 mM dose of the aminothiol WR-1065 significantly reduced their neoplastic transforming response to 56Fe particles. This model provides an opportunity to study the cellular and molecular mechanisms involved in malignant transformation of human epithelial cells by heavy ions. 相似文献
676.
The original basis for the Lorentz transformations, and thus special relativity, was the assumption that the observed velocity of interaction of light with matter represents a unique velocity of the electromagnetic wave. This arbitrary decision is not borne out by Maxwell's theories or by any test that might prove that EM energy actually travels in a continuum of velocities. The second postulate as stated by Einstein does not deserve the status of a postulate, as it is at once overly restrictive and ultimately phenomenological-the nature of c is based on experimental measurement rather than on analysis of first principles. The radiation continuum model's (RCM) modified second postulate, however, says nothing about the actual propagation of EM energy, but only of the relative speed with which it must interact with matter to be detected. Utilizing this modified light principle we obtain an intuitive Galilean form invariance for Maxwell's equations. RCM places no upper limit on attainable velocities, and allows for the possibility of communications between humans or particles at speeds far in excess of c. This precludes many of the compatibility problems between the highly successful quantum mechanics and relativity theory 相似文献
677.
J S Ferraro C A Fuller F M Sulzman 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》1989,9(11):251-260
The circadian rhythm of conidiation in Neurospora crassa is thought to be an endogenously derived circadian oscillation; however, several investigators have suggested that circadian rhythms may, instead, be driven by some geophysical time cue(s). An experiment was conducted on space shuttle flight STS-9 in order to test this hypothesis; during the first 7-8 cycles in space, there were several minor alterations observed in the conidiation rhythm, including an increase in the period of the oscillation, an increase in the variability of the growth rate and a diminished rhythm amplitude, which eventually damped out in 25% of the flight tubes. On day seven of flight, the tubes were exposed to light while their growth fronts were marked. Some aspect of the marking process reinstated a robust rhythm in all the tubes which continued throughout the remainder of the flight. These results from the last 86 hours of flight demonstrated that the rhythm can persist in space. Since the aberrant rhythmicity occurred prior to the marking procedure, but not after, it was hypothesized that the damping on STS-9 may have resulted from the hypergravity pulse of launch. To test this hypothesis, we conducted investigations into the effects of altered gravitational forces on conidiation. Exposure to hypergravity (via centrifugation), simulated microgravity (via the use of a clinostat) and altered orientations (via alterations in the vector of a 1 g force) were used to examine the effects of gravity upon the circadian rhythm of conidiation. 相似文献
678.
H. Fuke J.E. Koglin T. Yoshida T. Aramaki W.W. Craig L. Fabris F. Gahbauer C.J. Hailey F.J. Jou N. Madden K. Mori H.T. Yu K.P. Ziock 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2008,41(12):2056-2060
We discuss current progress and future plans for the general antiparticle spectrometer experiment (GAPS). GAPS detects antideuterons through the X-rays and pions emitted during the deexcitation of exotic atoms formed when the antideuterons are slowed down and stopped in targets. GAPS provides an exceptionally sensitive means to detect cosmic-ray antideuterons. Cosmic-ray antideuterons can provide indirect evidence for the existence of dark matter in such form as neutralinos or Kaluza–Klein particles. We describe results of accelerator testing of GAPS prototypes, tentative design concepts for a flight GAPS detector, and near-term plans for flying a GAPS prototype on a balloon. 相似文献
679.
C.M. Wrasse J. Fechine H. Takahashi C.M. Denardini J. Wickert M.G. Mlynczak J.M. Russell C.L. Barbosa 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2008,41(9):1423-1428
Global Positioning System (GPS) receiver on the CHAllenging Mini-satellite Payload (CHAMP) and the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument, one of four on board the TIMED satellite, provide middle atmosphere temperature profiles by Radio Occultation (RO) and limb viewing infrared emission measurements, respectively. These temperature profiles retrieved by two different techniques in the stratosphere are compared with each other using more than 1300 correlative profiles in March, September and December 2005. The over-all mean differences averaged over 15 and 35 km are approximately −2 K and standard deviation is less than 3 K. Below 20 km of altitude, relatively small mean temperature differences ∼1 K are observed in wide latitudinal range except for June (during the SABER nighttime observation). In the middle to low latitudes, between 30°S and 30°N, the temperature difference increases with height from ∼0–1 K at 15 km, to ∼−4 K at 35 km of altitude. Large temperature differences about −4 to −6 K are observed between 60°S and 30°N and 31–35 km of altitude for all months and between 0° and 30°N below 16 km during June (nighttime). 相似文献
680.
Y.S. Ge C.T. RussellT.-S. Hsu 《Advances in Space Research (includes Cospar's Information Bulletin, Space Research Today)》2008,41(8):1243-1251
In 2001, 2002 and 2003, the Polar spacecraft probed the near equatorial plasma sheet at 9 RE near local midnight. Using the magnetic field observations, the signatures at substorm onsets are studied. Close to the flux pile-up region, the Polar spacecraft readily detects the dipolarization front, especially for pseudo onsets. An event with two distinct onsets has been examined. The signatures are found to be consistent with the multiple-onset model suggested by Russell [Russell, C.T. How northward turnings of the IMF can lead to substorm expansion onsets. Geophys. Res. Lett. 27, 3257–3259, 2000] which is a modified Near-Earth Neutral Line (NENL) model. Another similar event is also examined showing the effects of different Interplanetary Magnetic Field (IMF) conditions upon substorms. Moreover, ground effects can be very weak compared to in situ observations, especially for pseudo onsets, because these signatures appear to be localized and not global. 相似文献