Effects of heavy particle irradiation and diet on object recognition memory in rats

On long-duration missions to other planets astronauts will be exposed to types and doses of radiation that are not experienced in low earth orbit. Previous research using a ground-based model for exposure to cosmic rays has shown that exposure to heavy particles, such as ⁵⁶Fe, disrupts spatial learning and memory measured using the Morris water maze. Maintaining rats on diets containing antioxidant phytochemicals for 2 weeks prior to irradiation ameliorated this deficit. The present experiments were designed to determine: (1) the generality of the particle-induced disruption of memory by examining the effects of exposure to ⁵⁶Fe particles on object recognition memory; and (2) whether maintaining rats on these antioxidant diets for 2 weeks prior to irradiation would also ameliorate any potential deficit. The results showed that exposure to low doses of ⁵⁶Fe particles does disrupt recognition memory and that maintaining rats on antioxidant diets containing blueberry and strawberry extract for only 2 weeks was effective in ameliorating the disruptive effects of irradiation. The results are discussed in terms of the mechanisms by which exposure to these particles may produce effects on neurocognitive performance.     

Constraints on the Structure of the Heliospheric Interface Based on Lyα Absorption Spectra

Spectroscopic observations of the hydrogen Lyα lines from nearby stars taken by the Hubble Space Telescope (HST) sometimes show absorption signatures from the heliosphere. This absorption is a unique diagnostic of material in the outermost parts of our heliosphere. We summarize how the HST data have been used to test various models of the heliosphere, particularly new 3-dimensional MHD models that have recently become available. We also focus on new detections of heliospheric absorption in very downwind directions, which can only be modeled using heliospheric model codes with extended grids in the downwind direction. We illustrate a couple attempts to reproduce this absorption using a couple of these extended tail models.     

Induction of vascular endothelial phenotype and cellular proliferation from human cord blood stem cells cultured in simulated microgravity

Recent studies have demonstrated that stem cells derived from adult hematopoietic tissues are capable of trans-differentiation into non-hematopoietic cells, and that the culture in microgravity (microg) may modulate the proliferation and differentiation. We investigated the application of microg to human umbilical cord blood stem cells (CBSC) in the induction of vascular endothelial phenotype expression and cellular proliferation. CD34+ mononuclear cells were isolated from waste human umbilical cord blood samples and cultured in simulated microg for 14 days. The cells were seeded in rotary wall vessels (RWV) with or without microcarrier beads (MCB) and vascular endothelial growth factor was added during culture. Controls consisted of culture in 1 G. The cell cultures in RWV were examined by inverted microscopy. Cell counts, endothelial cell and leukocyte markers performed by flow cytometry and FACS scan were assayed at days 1, 4, 7 and at the termination of the experiments. Culture in RWV revealed significantly increased cellular proliferation with three-dimensional (3D) tissue-like aggregates. At day 4, CD34+ cells cultured in RWV bioreactor without MCB developed vascular tubular assemblies and exhibited endothelial phenotypic markers. These data suggest that CD34+ human umbilical cord blood progenitors are capable of trans-differentiation into vascular endothelial cell phenotype and assemble into 3D tissue structures. Culture of CBSC in simulated microg may be potentially beneficial in the fields of stem cell biology and somatic cell therapy.     

New EXOSAT results from the intermediate polar V1223 SGR

We report new results obtained from the EXOSAT AO- 1 observation of the intermediate polar V1223 Sgr. The detection of a 12.4 minute period in the medium energy X-ray flux with an associated hardness ratio variation has been previously reported in Osborne et al. (1984a). Further work has revealed: a narrow dip at the phase zero in the folded medium energy light curve; 30% modulation in the low energy X-ray (3000 Lexan) flux; a count rate ratio from 3 filters which allow the presence of a bright low temperature blackbody component (kT = .05 –. 40 KeV); and a phase resolved ME spectrum which must have two or more components when the source is bright. New optical ephemerides show that the X-ray and optical pulses are in phase at an orbital phase of = 0.31.Affiliated to the Astrophysics Division, Space Science Dept., ESA     

Heliospheric Lessons for Galactic Cosmic-ray Acceleration

The heliosphere is bathed in the supersonic solar wind, which generally creates shocks at any obstacles it encounters: magnetic structures such as coronal mass ejections and planetary magnetospheres, or fast-slow stream interactions such as corotating interaction regions (CIRs) or the termination shock. Each of these shock structures has an associated energetic particle population whose spectra and composition contain clues to the acceleration process and the sources of the particles. Over the past several years, the solar wind composition has been systematically studied, and the long-standing gap between high energy (>1 MeV amu^–1) and the plasma ion populations has been closed by instruments capable of measuring the suprathermal ion composition. In CIRs, where it has been possible to observe all the relevant populations, it turns out that the suprathermal ion population near 1.8–2.5 times the solar wind speed is the seed population that gets accelerated, not the bulk particles near the solar wind peak. These new results are of interest to the problem of Galactic Cosmic-Ray (GCR) Acceleration, since the injection and acceleration of GCRs to modest energies is likely to share many features with processes we can observe in detail in the heliosphere.     

Precise navigation using adaptive FIR filtering and time domainspectral estimation

This paper introduces a new low cost, short range, positioning system based on adaptive finite impulse response (FIR) filtering and time domain spectral estimation. The system can determine absolute positions with a high degree of accuracy and is well suited for real time navigation. The approach is based upon signal processing techniques and a priori knowledge of the system transfer function. The first step is to measure the phase response of the linear transfer function and then using a FIR filter the time response of the system can be determined. The FIR filter computes the time response by performing a deconvolution between the measured phase response, and the complex conjugate of the transfer function. By correlating the known input impulse response with the output of the FIR filter, an error term is generated. The time delay of the system is determined by adjusting the FIR filter coefficients to minimize the error term. Simulated analysis of the system indicates a worst case error of ±16 cm     

Deep Impact: The Anticipated Flight Data

A comprehensive observational sequence using the Deep Impact (DI) spacecraft instruments (consisting of cameras with two different focal lengths and an infrared spectrometer) will yield data that will permit characterization of the nucleus and coma of comet Tempel 1, both before and after impact by the DI Impactor. Within the constraints of the mission system, the planned data return has been optimized. A subset of the most valuable data is planned for return in near-real time to ensure that the DI mission success criteria will be met even if the spacecraft should not survive the comet’s closest approach. The remaining prime science data will be played back during the first day after the closest approach. The flight data set will include approach observations spanning the 60 days prior to encounter, pre-impact data to characterize the comet at high resolution just prior to impact, photos from the Impactor as it plunges toward the nucleus surface (including resolutions exceeding 1 m), sub-second time sampling of the impact event itself from the Flyby spacecraft, monitoring of the crater formation process and ejecta outflow for over 10 min after impact, observations of the interior of the fully formed crater at spatial resolutions down to a few meters, and high-phase lookback observations of the nucleus and coma for 60 h after closest approach. An inflight calibration data set to accurately characterize the instruments’ performance is also planned. A ground data processing pipeline is under development at Cornell University that will efficiently convert the raw flight data files into calibrated images and spectral maps as well as produce validated archival data sets for delivery to NASA’s Planetary Data System within 6 months after the Earth receipt for use by researchers world-wide.     

Tides and the evolution of planetary habitability

Tides raised on a planet by the gravity of its host star can reduce the planet's orbital semi-major axis and eccentricity. This effect is only relevant for planets orbiting very close to their host stars. The habitable zones of low-mass stars are also close in, and tides can alter the orbits of planets in these locations. We calculate the tidal evolution of hypothetical terrestrial planets around low-mass stars and show that tides can evolve planets past the inner edge of the habitable zone, sometimes in less than 1 billion years. This migration requires large eccentricities (>0.5) and low-mass stars ( less or similar to 0.35 M(circle)). Such migration may have important implications for the evolution of the atmosphere, internal heating, and the Gaia hypothesis. Similarly, a planet that is detected interior to the habitable zone could have been habitable in the past. We consider the past habitability of the recently discovered, approximately 5 M(circle) planet, Gliese 581 c. We find that it could have been habitable for reasonable choices of orbital and physical properties as recently as 2 Gyr ago. However, when constraints derived from the additional companions are included, most parameter choices that indicate past habitability require the two inner planets of the system to have crossed their mutual 3:1 mean motion resonance. As this crossing would likely have resulted in resonance capture, which is not observed, we conclude that Gl 581 c was probably never habitable.     

Adenine synthesis in interstellar space: mechanisms of prebiotic pyrimidine-ring formation of monocyclic HCN-pentamers

The question whether the nucleobases can be synthesized in interstellar space is of fundamental significance in considerations of the origin of life. Adenine is formally the HCN pentamer, and experiments have demonstrated that adenine is formed under certain conditions by HCN pentamerization in gas, liquid, and condensed phases. Most mechanistic proposals invoke the intermediacy of the HCN tetramer AICN (4), and it is thought that adenine synthesis is completed by addition of the 5(th) HCN to 4 to form amidine 5 and subsequent pyrimidine cyclization. In this context, we have been studying the mechanism for prebiotic pyrimidine-ring formation of monocyclic HCN-pentamers with ab initio electronic structure theory. The calculations model gas phase chemistry, and the results primarily inform discussions of adenine synthesis in interstellar space. Purine formation requires tautomerization of 5 to the conjugated amidine 6 (via hydrogen-tunneling, thermally with H(+) -catalysis, or by photolysis) or to keteneimine 7 (by photolysis). It was found that 5-(N'-formamidinyl)-1H-imidazole-4-carbonitrile (6) can serve as a substrate for proton-catalyzed purine formation under photolytic conditions and N-(4-(iminomethylene)-1H-imidazol-5(4H)-ylidene)formamidine (7) can serve as a substrate for uncatalyzed purine formation under photolytic conditions. The absence of any sizeable activation barrier for the cyclization of 7 to the (Z)-imino form of 9H-adenine (Z)-2 is quite remarkable, and it is this feature that allows for the formation of the purine skeleton from 7 without any further activation.