Genetic susceptibility to radiation.

In the context of space radiation, it is important to know whether the human population includes genetically predisposed radiosensitive subsets. One possibility is that haploinsufficiency for ATM confers radiosensitivity, and this defect involves 1-3% of the population. Using knock-out mice we chose to study cataractogenesis in the lens and oncogenic transformation in mouse embryo fibroblasts to assay for effects of ATM deficiency. Radiation induced cataracts appeared earlier in the heterozygous versus wild-type animals following exposure to either gamma rays or 1 GeV/nucleon iron ions. In addition, it was found that embryo fibroblasts of Atm heterozygotes showed an increased incidence of oncogenic transformation compared with their normal litter-matched counterparts. From these data we suggest that Ataxia Telangiectasia heterozygotes could indeed represent a societally significant radio sensitive subpopulation. Knock-out mice are now available for other genes including BRCA1 and 2, and Mrad9. An exciting possibility is the creation of double heterozygotes for pairs of mutated genes that function in the same signal transduction pathway, and consequently confer even greater radiosensitivity.     

Nonuniform array processing via the polynomial approach

A polynomial approach for maximum-likelihood (ML) estimation of superimposed signals in time-series problems and array processing was recently proposed. This technique was applied successfully to linear uniform arrays and to uniformly sampled complex exponential signals. However, uniformly spaced arrays are not optimal for minimum variance estimation of bearing, range or position, and uniform sampling of signals is not always possible in practice. The authors make use of the expectation-maximization algorithm to apply the polynomial approach to sublattice arrays and to missing samples in time-series problems     

Sikkim's Teesta River fog, mist and dust particle monitoring using monostatic LIDAR

Fog, mist, and atmospheric dust particles, having the dimension of one micrometer or less, play an important role in the deterioration of visibility, as well as in causing local warming in the atmosphere. With an attempt to reduce the deterioration, a scientific approach has to be taken to determine their origins. A monostatic LIDAR may be one of the best instruments for such work. The authors are tempted to develop such a LIDAR for fog, mist, and dust particle monitoring over River Teesta at Sikkim. LIDAR is an acronym for Light Detection And Ranging. What can we do with LIDAR? Measure distance, measure speed, measure rotation, measure chemical composition and concentration, and measure cross-sections of the targets. The digital technique is always utilized for its development which results in better security, lower power consumption, higher power efficiency, higher reliability, lower transmitter power, lower multipath effect, higher interference suppression as compared to an analog system. The commercial systems like disdometer, rain radar, mobile robot, etc., utilizing LIDAR principles are operational in different parts of the world. The authors are highly motivated for such LIDAR development and their development effort follows.     

Stirling machines come of age

A brief overview is given of the current status of Stirling machine technology. The first commercial device, a Vuilleumier heat pump, is described. Some potential applications of Stirling engines are examined     

Current and potential productivity of wheat for a Controlled Environment Life Support System.

The productivity of higher plants is determined by the incident photosynthetic photon flux (PPF) and the efficiency of the following four physiological processes: absorption of PPF by photosynthetic tissue, carbon fixation (photosynthesis), carbon use (respiration), and carbon partitioning (harvest index). These constituent processes are analyzed to determine theoretical and potentially achievable productivity. The effects of optimal environmental and cultural factors on each of these four factors is also analyzed. Results indicate that an increase in the percentage of absorbed photons is responsible for most of the improvement in wheat yields in an optimal controlled environment. Several trials confirm that there is an almost linear increase in wheat yields with increasing PPF. An integrated PPF of 150 mol m-2 d-1 (2.5 times summer sunlight) has produced 60 g m-2 d-1 of grain. Apparently, yield would continue to increase with even higher PPF's. Energy efficiency increased with PPF to about 600 micromoles m-2 s-1, then slowly decreased. We are now seeking to improve efficiency at intermediate PPF levels (1000 micromoles m-2 s-1) before further exploring potential productivity. At intermediate and equal integrated daily PPF levels, photoperiod had little effect on yield per day or energy efficiency. Decreasing temperature from 23 degrees to 17 degrees increased yield per day by 20% but increased the life cycle from 62 to 89 days. We hope to achieve both high productivity and energy efficiency.     

The quantification of wound healing as a method to assess late radiation damage in primate skin exposed to high-energy protons.

In an experiment examining the effects of space radiations on primates, different groups of rhesus monkeys (Macaca mulatta) were exposed to single whole-body doses of 32- or 55-MeV protons. Survivors of those exposures, together with age-matched controls, have been monitored continuously since 1964 and 1965. Late effects of nominal proton doses ranging from 2-6 Gray have been measured in vitro using skin fibroblasts from the animals. A logical extension of that study is reported here, and it involves observations of wound healing after 3-mm diameter dermal punches were removed from the ears (pinnae) of control and irradiated monkeys. Tendencies in the reduction of competence to repair cutaneous wounds have been revealed by the initial examinations of animals that received doses greater than 2 Gy more than 2 decades earlier. These trends indicate that this method of assessing radiation damage to skin exposed to high-energy radiations warrants further study.     

The exact Cramer-Rao bound for Gaussian autoregressive processes

An explicit expression is derived for the Cramer-Rao bound (CRB) on unbiased estimates of the parameters of autoregressive (AR) processes, given a finite number of measurements. The expression converges to the well-known asymptotic form of the CRB when the number of measurements tends to infinity. The behavior of the bound is illustrated by some numerical examples     

Integrated CIS VLF/Omega receiver design

The design of an integrated Russian-VLF/Omega receiver implemented on a TMS320C30-microprocessor-based SPECTRUM plug-in board installed in a PC-compatible portable computer is presented. The system also requires an external antenna, pre-amp, and frequency reference. The SPECTRUM board digitizes the RF signal to 16 b and then digitally mixes with the sines and cosines of the three Russian frequencies plus 10.2, 11-1/3, and 13.6 kHz. The mixer outputs are low-pass filtered, and the comb filters are implemented for the respective epochs. The computer accesses and processes the comb filter outputs, calculating and logging signal phase and amplitude. The design allows for easy future expansion to include unique and VLF communication frequencies     

Chemical heating rates derived from SCIAMACHY vibrationally excited OH limb emission spectra

The SCIAMACHY instrument on board Envisat is able to measure nearly all vibrational transitions of mesospheric hydroxyl – from the ultraviolet to the near infrared spectral region.

In this paper, we analyze SCIAMACHY limb emission data in the 1000–1750 nm spectral region by means of a new vibrational non-LTE model of OH. Several hydroxyl hotbands are identified. Vibrational non-LTE model calculations applying different collisional relaxation models are able to reproduce the measured spectra. Best agreement between model calculations and measured spectra is obtained, if a combination of multiquantum and step ladder single-quantum relaxation model is applied. Emissions from the OH(v = 9) vibrational state are used to derive chemical heating rates from the SCIAMACHY spectra. Instantaneous heating rates are in the order of 10 K/day.     

Application of periodic solutions of three-dimensional three-body problem to designing the orbit of a space telescope

A method of constructing three-dimensional orbits with a necessary evolution in the system the Sun — (Earth + Moon) is described. The orbit (promising from the viewpoint of solving formulated research problems) of the Millimetron spacecraft is suggested. Feasibility of such an orbit is demonstrated, as well as a possibility to observe with its help the majority of objects on the celestial sphere and to transmit the data to the Earth.