A new perspective of carcinogenesis from protracted high-LET radiation arises from the two-stage clonal expansion model.

When applied to the Colorado Plateau miner population, the two-stage clonal expansion (TSCE) model of radiation carcinogenesis predicts that radiation-induced promotion dominates radiation-induced initiation. Thus, according to the model, at least for alpha-particle radiation from inhaled radon daughters, lung cancer induction over long periods of protracted irradiation appears to be dominated by radiation-induced modification of the proliferation kinetics of already-initiated cells rather than by direct radiation-induced initiation (i.e., mutation) of normal cells. We explore the possible consequences of this result for radiation exposures to space travelers on long missions. Still unknown is the LET dependence of this effect. Speculations of the cause of this phenomenon include the suggestion that modification of cell kinetics is caused by a "bystander" effect, i.e., the traversal of normal cells by alpha particles, followed by the signaling of these cells to nearby initiated cells which then modify their proliferation kinetics.     

Autogeneration of an Instability of a Plasma Composition Equilibrium in the Plasmaspheric Transition Region during a Postsunset High-Altitude Launch of the Vertikal'-10 Rocket

A cause of the instability of equilibrium of plasma ion composition is discussed and exemplified by the data on a burst of amplitudes of small-scale plasma irregularities in the plasmaspheric transition region during an evening launch of the Vertikal'-10 rocket. This burst is accompanied by a simultaneous decrease in the average plasma density at altitudes of 700–1100 km. Specific features of the observed events are compared to postsunset incoherent scatter radar observations of the ion diffusion flux density. It is demonstrated that the instability is caused by peculiarities of the protonosphere–ionosphere interaction associated with a sharp difference between thermal conditions of the ionospheric and protonospheric air shortly after sunset. The induced nonuniformity of postsunset cooling of the protonospheric–ionospheric plasma causes density irregularities in ion diffusion fluxes and generates local bunches of heavy ions, which are usually only a minor impurity to lighter ions. As a result, conditions are created that are favorable for the nondissipative accumulation of potential energy for the mutual opposition of two or more groups of ions with different masses and for the subsequent release of this energy by a threshold excitation of impurity-driven plasma instabilities.     

Life before RNA

The hypothesis that life originated and evolved from linear informational molecules capable of facilitating their own catalytic replication is deeply entrenched. However, widespread acceptance of this paradigm seems oblivious to a lack of direct experimental support. Here, we outline the fundamental objections to the de novo appearance of linear, self-replicating polymers and examine an alternative hypothesis of template-directed coding of peptide catalysts by adsorbed purine bases. The bases (which encode biological information in modern nucleic acids) spontaneously self-organize into two-dimensional molecular solids adsorbed to the uncharged surfaces of crystalline minerals; their molecular arrangement is specified by hydrogen bonding rules between adjacent molecules and can possess the aperiodic complexity to encode putative protobiological information. The persistence of such information through self-reproduction, together with the capacity of adsorbed bases to exhibit enantiomorphism and effect amino acid discrimination, would seem to provide the necessary machinery for a primitive genetic coding mechanism.     

Eye light flashes on the Mir space station

The phenomenon of light flashes (LF) in eyes for people in space has been investigated onboard Mir. Data on particles hitting the eye have been collected with the SilEye detectors, and correlated with human observations. It is found that a nucleus in the radiation environment of Mir has roughly a 1% probability to cause an LF, whereas the proton probability is almost three orders of magnitude less. As a function of LET, the LF probability increases above 10 keV/micrometer, reaching about 5% at around 50 keV/micrometer.     

Lunar polar ice deposits: scientific and utilization objectives of the Lunar Ice Discovery Mission proposal

The Clementine mission has revived interest in the possibility that ice exists in shadowed craters near the lunar poles. Theoretically, the problem is complex, with several possible sources of water (meteoroid, asteroid, comet impact), several possible loss mechanisms (impact vaporization, sputtering, photoionization), and burial by meteorite impact. Opinions of modelers have ranged from no ice to several times 10(16) g of ice in the cold traps. Clementine bistatic radar data have been interpreted in favor of the presence of ice, while Arecibo radar data do not confirm its presence. The Lunar Prospector mission, planned to be flown in the fall of 1997, could gather new evidence for the existence of ice. If ice is present, both scientific and utilitarian objectives would be addressed by a lunar polar rover, such as that proposed to the NASA Discovery program, but not selected. The lunar polar rover remains the best way to understand the distribution and characteristics of lunar polar ice.     

Nonlinear Localized Electrostatic Structures and Their Experimental Diagnostics in the Magnetosphere Plasma

The theoretical models of the formation of the three-dimensional quasi-stationary structures of variations of density and electrostatic potential in a multicomponent magnetosphere plasma are considered. On the basis of the perturbation method, we have studied the domains of the parametric space, where the occurrence of nonlinear quasi-stationary ion-acoustic and electron-acoustic structures are possible. For these structures, the velocities of motion along the direction of the magnetic field are estimated, together with the longitudinal and transverse scales with respect to the direction of the Earth's magnetic field. The calculated dependences of the scales l and l _|| of the structures on the plasma parameters in the three-component plasma allow one to compare the results of the considered theoretical models with new experimental data of measuring the form of soliton structures onboard the FAST, POLAR, and GEOTAIL satellites.     

Long-term operation of "Orlan" space suits in the "Mir" orbiting station: experience obtained and its application

The started assembly of the International Space Station (ISS) and its further operation will call for a great number of extravehicular activity sorties (EVA) to be performed by ISS crews. Therefore, of great importance is to make use of the EVA experience gained by cosmonauts in the process of 15-year operation of the Mir orbiting station (OS). Over the 15-year period, Mir crewmembers wearing Orlan type semi-rigid space suits have accumulated 158 man/sorties from the orbiting station. Crewmembers used 15 suits in orbit and some of the suits were in operation for more than 3 years. The paper presents principal design features, which provide effective and safe operation of orbit-based suits, and briefly describes procedures for preparation and maintenance of suit systems, which ensure long-term operation of space suit in orbit. The paper gives results of the space suit modifications, presents suit performance characteristics and lists novel or upgraded components of the space suit and its systems. The paper also summarizes improvements in the Orlan type suits described in some earlier publications. They refer, in the first run, to the improvement of space suit operations characteristics and reliability, and the utilization of the Orlan type space suit in the ISS program. The paper analyses the experience gained and drawbacks detected and observations made, and gives statistical data on long-term space suit operations aboard the Mir station. The paper reviews certain problems in the process of EVAs performed from the station, and describes the ways of their solution as applied to the further utilization of the suit within the ISS program.     

Study of cosmic rays and light flashes on board Space Station MIR: the SilEye experiment.

The SilEye experiment aims to study the cause and processes related to the anomalous Light Flashes (LF) perceived by astronauts in orbit and their relation with Cosmic Rays. These observations will be also useful in the study of the long duration manned space flight environment. Two PC-driven silicon detector telescopes have been built and placed aboard Space Station MIR. SilEye-1 was launched in 1995 and provided particles track and LF information; the data gathered indicate a linear dependence of FLF(Hz) ( 4 2) 10(3) 5.3 1.7 10(4) Fpart(Hz) if South Atlantic Anomaly fluxes are not included. Even though higher statistic is required, this is an indication that heavy ion interactions with the eye are the main LF cause. To improve quality and quantity of measurements, a second apparatus, SilEye-2, was placed on MIR in 1997, and started work from August 1998. This instrument provides energetic information, which allows nuclear identification in selected energy ranges; we present preliminary measurements of the radiation field inside MIR performed with SilEye-2 detector in June 1998.     

Halo White Dwarfs and Baryonic Dark Matter

We describe the formation of hot intergalactic gas along with baryonic remnants in galaxy halos. In this scenario, the mass and metallicity of the hot intracluster and intragroup gas relates directly to the production of baryonic remnants during the collapse of galactic halos. We construct a schematic but self-consistent model in which early bursts of star formation lead to a large remnant population in the halo, and to the outflow of stellar ejecta into the halo and ultimately the Local Group. We consider local as well as high redshift constraints on this scenario. This study suggests that the microlensing objects in the Galactic halo may predominantly be 0.5M white dwarfs, assuming that the initial mass function for early star formation favored the formation of intermediate mass stars with m 1M. However, the bulk of the baryonic dark matter in this scenario is associated with the ejecta of the white dwarf progenitors, and resides in the hot intergalactic medium.     

The sopite syndrome revisited: drowsiness and mood changes during real or apparent motion

The sopite syndrome is a poorly understood response to motion. Drowsiness and mood changes are the primary characteristics of the syndrome. The sopite syndrome can exist in isolation from more apparent symptoms such as nausea, can last long after nausea has subsided, and can debilitate some individuals. It is most likely a distinct syndrome from "regular" motion sickness or common fatigue, and is of potential concern in a variety of situations. The syndrome may be particularly hazardous in transportation settings where other performance challenges (e.g., sleep deprivation) are already present. It is also a potential concern in cases where illnesses such as sleep disorders or depression may interact with the syndrome and confuse diagnosis.